单纯庚型肝炎病毒感染肝组织中糖复合物的表达

To investigate the feature of glycoconjugates expression in human liver tissues infected with hepatitis G virus and to speculate upon the mechanism of HGV in fection. This study contains 10 normal liver tissues of controls and liver tissues obtained through biopsy from 22 patients with HGV infection for the purpose of diagnosis. SP immunohistochemistry for 9 different lectins was applied to the paraffin liver sections. The positive rates of the lectin were calculated and compared between the controls and the patients.x 2 test was used for the comparison of difference between them. In the controls, DSL, PHA-E, DBA and STL receptors were weakly positive on the membrane of hepatocytes; while in the patients, staining for DBA receptor became stronger. three new lectin-receptors, PHA-L, UEA-Ⅰ and ECL were noted on the liver cell membrane in the tissues infected with HGV. Alterations in quality and structure of glycoconjugates exepression took place in liver tissues, especially on the cell membrane from the patients with HGV infection. This finding might be valuable to investigation of HGV infection mechanism.