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Feb.  2007
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Article Navigation >  Journal of Clinical Hepatology  > 2007  >  23(2): 98-99

GBV-C/HGV在血清学非甲～戊型急性肝炎发生中的作用

  • Published Date: 2007-02-20
    Abstract
  • To investigate the role of GB virus C/hepatitis G virus (GBV-C/HGV) on the etiology of acute non AE hepatitis.Liver biopsy from 56 patients with acute non AE hepatitis were detected for GBV-C/HGV non-structure 5 antigen (NS5 Ag) by immunohistochemistry.The pathological results and the clinical data were analyzed.In acute non AE hepatitis, the total positive rate of GBV-C/HGV NS5 Ag in liver tissues was 53.6%.The majority were coinfected with HBV or HCV.The liver function test (ALT) in acute hepatitis B or C was similar in patients coinfected and in those not coinfected with GBV-C/HGV.Only 16.1% were infected with GBV-C/HGV alone.The ALT were significantly lower in the patients with GBV-C/HGV infected alone than those with HBV or HCV co infected, but similar to those in acute hepatitis of unknown etiology.The pathogenicity of GBV-C/HGV is doubtful.GBV-C/HGV may not be one of the main pathogenic agents of acute hepatitis.

     

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    • References(4)
  • [1]Seifried C, Weber M, Bialleck H, et al.High prevalence of GBV-C/HGV among relatives of GBV-C/HGV-positive blood donors inblood recipients and in patients with aplastic anemia[J].Transfu-sion, 2004, 44 (2) ∶268-274.
    [2]Jeon MJ, Shin JH, Suh SP, et al.TTvirus and hepatitis G virus in-fections in Korean blood donors and patients with chronic liver dis-ease[J].World J Gastroenterol, 2003, 9 (4) ∶741-744.
    [3]许家璋, 鞠九龙, 杨志国, 等.庚型肝炎病毒感染中国恒河猴血清学和肝细胞学的动态观察[J].中华实验和临床病毒学杂志, 1999, 13 (1) ∶71-73.
    [4]Bjorkman P, Sundstrom G, Veress B, et al.Assessment of liver dis-ease and biochemical and immunological markers in Swedish blooddonors with isolated GB virus C/hepatitis G virus viremia[J].Vox-Sang, 2000, 78 (3) ∶143-148.
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