GBV-C/HGV在血清学非甲～戊型急性肝炎发生中的作用

To investigate the role of GB virus C/hepatitis G virus (GBV-C/HGV) on the etiology of acute non AE hepatitis.Liver biopsy from 56 patients with acute non AE hepatitis were detected for GBV-C/HGV non-structure 5 antigen (NS5 Ag) by immunohistochemistry.The pathological results and the clinical data were analyzed.In acute non AE hepatitis, the total positive rate of GBV-C/HGV NS5 Ag in liver tissues was 53.6%.The majority were coinfected with HBV or HCV.The liver function test (ALT) in acute hepatitis B or C was similar in patients coinfected and in those not coinfected with GBV-C/HGV.Only 16.1% were infected with GBV-C/HGV alone.The ALT were significantly lower in the patients with GBV-C/HGV infected alone than those with HBV or HCV co infected, but similar to those in acute hepatitis of unknown etiology.The pathogenicity of GBV-C/HGV is doubtful.GBV-C/HGV may not be one of the main pathogenic agents of acute hepatitis.