Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

Xie XiaoHong; Yang DongLiang; Liu Jia

doi:10.3969/j.issn.1001-5256.2020.05.002

Volume 36 Issue 5

May 2020

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Article Navigation > Journal of Clinical Hepatology > 2020 > 36(5): 965-970

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Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

DOI: 10.3969/j.issn.1001-5256.2020.05.002

Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China

Research funding:

Published Date: 2020-05-20

Abstract

Abstract

The liver has a unique immune microenvironment, and the intrinsic antigen-presenting cells in the liver interact with each other and form a network to accurately regulate the homeostasis between liver immune tolerance and immune response. During hepatitis B virus(HBV) infection, on the one hand, the intrahepatic intrinsic antigen-presenting cells induce immune tolerance to help the virus escape immune clearance and thus result in persistent infection; on the other hand, the maturation and activation of the intrahepatic intrinsic antigen-presenting cells can also mediate effective anti-HBV immune response to achieve virus clearance. This article elaborates on the research advances in the role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating immune response against HBV infection.
- hepatitis B virus,
- hepatitis B,chronic,
- antigen-presenting cells,
- liver sinusoidal endothelial cell,
- Kupffer cells

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References

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Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

DOI: 10.3969/j.issn.1001-5256.2020.05.002