Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

Xie XiaoHong; Yang DongLiang; Liu Jia

doi:10.3969/j.issn.1001-5256.2020.05.002

Volume 36 Issue 5

May 2020

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Article Navigation > Journal of Clinical Hepatology > 2020 > 36(5): 965-970

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Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

DOI: 10.3969/j.issn.1001-5256.2020.05.002

Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China

Research funding:

Published Date: 2020-05-20

Abstract

Abstract

The liver has a unique immune microenvironment, and the intrinsic antigen-presenting cells in the liver interact with each other and form a network to accurately regulate the homeostasis between liver immune tolerance and immune response. During hepatitis B virus(HBV) infection, on the one hand, the intrahepatic intrinsic antigen-presenting cells induce immune tolerance to help the virus escape immune clearance and thus result in persistent infection; on the other hand, the maturation and activation of the intrahepatic intrinsic antigen-presenting cells can also mediate effective anti-HBV immune response to achieve virus clearance. This article elaborates on the research advances in the role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating immune response against HBV infection.
- hepatitis B virus,
- hepatitis B,chronic,
- antigen-presenting cells,
- liver sinusoidal endothelial cell,
- Kupffer cells

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References

[1] LU FM, ZHUANG H. Management of hepatitis B in China[J].Chin Med J, 2009, 122(1):3-4.

[2] JENNE CN, KUBES P. Immune surveillance by the liver[J].Nat Immunol, 2013, 14(10):996-1006.

[3] THOMSON AW, KNOLLE PA. Antigen-presenting cell function in the tolerogenic liver environment[J]. Nat Rev Immunol,2010, 10(11):753-766.

[4] ADKINS B, BU Y, GUEVARA P. Murine neonatal CD4+lymph node cells are highly deficient in the development of antigenspecific Th1 function in adoptive adult hosts[J]. J Immunol,2002, 169(9):4998-5004.

[5] CARAMBIA A, FREUND B, SCHWINGE D, et al. TGF-β-dependent induction of CD4+CD25+Foxp3+Tregs by liver sinusoidal endothelial cells[J]. J Hepatol, 2014, 61(3):594-599.

[6] LIMMER A, OHL J, KURTS C, et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+T cells results in antigen-specific T-cell tolerance[J]. Nat Med,2000, 6(12):1348-1354.

[7] LOHSE AW, KNOLLE PA, BILO K, et al. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells[J]. Gastroenterology, 1996, 110(4):1175-1181.

[8] SCHURICH A, BÖTTCHER JP, BURGDORF S, et al. Ditinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells[J]. Hepatology,2009, 50(3):909-919.

[9] von OPPEN N, SCHURICH A, HEGENBARTH S, et al. Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization[J]. Hepatology, 2009, 49(5):1664-1672.

[10] DIEHL L, SCHURICH A, GROCHTMANN R, et al. Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+T cell tolerance[J]. Hepatology, 2008, 47(1):296-305.

[11] LU Y, WANG B, HUANG H, et al. The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection[J]. Dev Comp Immunol, 2008, 32(4):445-457.

[12] LIU J, JIANG M, MA Z, et al. TLR1/2 ligand-stimulated mouse liver endothelial cel s secrete IL-12 and trigger CD8+T cell immunity in vitro[J]. J Immunol, 2013, 191(12):6178-6190.

[13] UHRIG A, BANAFSCHE R, KREMER M, et al. Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver[J]. J Leukoc Biol, 2005, 77(5):626-633.

[14] KNOLLE PA, SCHMITT E, JIN S, et al. Induction of cytokine production in naive CD4(+)T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells[J]. Gastroenterology, 1999, 116(6):1428-1440.

[15] SCHILDBERG FA, HEGENBARTH SI, SCHUMAK B, et al. Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells[J]. Eur J Immunol, 2008,38(4):957-967.

[16] KNOLLE PA, UHRIG A, HEGENBARTH S, et al. IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules[J]. Clin Exp Immunol, 1998, 114(3):427-433.

[17] NURIEVA R, THOMAS S, NGUYEN T, et al. T-cell tolerance or function is determined by combinatorial costimulatory signals[J]. EMBO J, 2006, 25(11):2623-2633.

[18] SCHURICH A, BERG M, STABENOW D, et al. Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells[J]. J Immunol, 2010, 184(8):4107-4114.

[19] KERN M, POPOV A, SCHOLZ K, et al. Virally infected mouse liver endothelial cells trigger CD8+T-cell immunity[J]. Gastroenterology, 2010, 138(1):336-346.

[20] BÖTTCHER JP, SCHANZ O, WOHLLEBER D, et al. Liverprimed memory T cells generated under noninflammatory conditions provide anti-infectious immunity[J]. Cell Rep, 2013,3(3):779-795.

[21] BÖTTCHER JP, SCHANZ O, GARBERS C, et al. IL-6 transsignaling-dependent rapid development of cytotoxic CD8+T cell function[J]. Cell Rep, 2014, 8(5):1318-1327.

[22] WITTLICH M, DUDEK M, BÖTTCHER JP, et al. Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2[J]. J Hepatol, 2017, 66(5):978-986.

[23] HUANG S, ZOU S, CHEN M, et al. Local stimulation of liver sinusoidal endothelial cells with a NOD1 agonist activates T cells and suppresses hepatitis B virus replication in mice[J].J Immunol, 2018, 200(9):3170-3179.

[24] HUANG S, WU J, GAO X, et al. LSECs express functional NOD1 receptors:A role for NOD1 in LSEC maturation-induced T cell immunity in vitro[J]. Mol Immunol, 2018, 101:167-175.

[25] YANG S, WANG L, PAN W, et al. MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance[J]. J Hepatol,2019, 71(4):685-698.

[26] GUIDOTTI LG, INVERSO D, SIRONI L, et al. Immunosurveillance of the liver by intravascular effector CD8(+)T cells[J].Cell, 2015, 161(3):486-500.

[27] MASS E, BALLESTEROS I, FARLIK M, et al. Specification of tissue-resident macrophages during organogenesis[J]. Science, 2016, 353(6304):aaf4238.

[28] INABA K, WITMER-PACK M, INABA M, et al. The tissue distribution of the B7-2 costimulator in mice:Abundant expression on dendritic cells in situ and during maturation in vitro[J]. J Exp Med, 1994, 180(5):1849-1860.

[29] RUBINSTEIN D, ROSKA AK, LIPSKY PE. Antigen presentation by liver sinusoidal lining cells after antigen exposure in vivo[J]. J Immunol, 1987, 138(5):1377-1382.

[30] ROLAND CR, MANGINO MJ, DUFFY BF, et al. Lymphocyte suppression by Kupffer cells prevents portal venous tolerance induction:A study of macrophage function after intravenous gadolinium[J]. Transplantation, 1993, 55(5):1151-1158.

[31] GUIDOTTI LG, BORROW P, BROWN A, et al. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte[J]. J Exp Med, 1999, 189(10):1555-1564.

[32] PASQUETTO V, GUIDOTTI LG, KAKIMI K, et al. Host-virus interactions during malaria infection in hepatitis B virus transgenic mice[J]. J Exp Med, 2000, 192(4):529-536.

[33] XU L, YIN W, SUN R, et al. Kupffer cell-derived IL-10plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice[J]. Hepatology, 2014, 59(2):443-452.

[34] LOKHONINA A, ELCHANINOV A, FATKHUDINOV T, et al.Activated macrophages of monocytic origin predominantly express proinflammatory cytokine genes, whereas kupffer cells predominantly express anti-inflammatory cytokine genes[J].Biomed Res Int, 2019, 2019:3912142.

[35] YOU Q, CHENG L, KEDL RM, et al. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells[J]. Hepatology, 2008, 48(3):978-990.

[36] KNOLLE P, SCHLAAK J, UHRIG A, et al. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide(LPS)challenge[J]. J Hepatol, 1995, 22(2):226-229.

[37] LIU J, YU Q, WU W, et al. TLR2 Stimulation strengthens intrahepatic myeloid-derived cell-mediated T cell tolerance through inducing Kupffer cell expansion and IL-10 production[J]. J Immunol, 2018, 200(7):2341-2351.

[38] BURGIO VL, BALLARDINI G, ARTINI M, et al. Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology[J]. Hepatology, 1998, 27(6):1600-1606.

[39] TIAN Y, KUO CF, AKBARI O, et al. Maternal-derived hepatitis B virus e antigen alters macrophage function in offspring to drive viral persistence after vertical transmission[J]. Immunity, 2016, 44(5):1204-1214.

[40] WU LL, PENG WH, WU HL, et al. Lymphocyte antigen 6complex, locus C+monocytes and Kupffer cells orchestrate liver immune responses against hepatitis B virus in mice[J].Hepatology, 2019, 69(6):2364-2380.

[41] CHOU HH, CHIEN WH, WU LL, et al. Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota[J]. Proc Natl Acad Sci U S A, 2015,112(7):2175-2180.

[42] LI M, SUN R, XU L, et al. Kupffer cells support hepatitis B virus-mediated CD8+T cell exhaustion via hepatitis B core antigen-TLR2 interactions in mice[J]. J Immunol, 2015, 195(7):3100-3109.

[43] CHENG X, XIA Y, SERTI E, et al. Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages[J]. Hepatology, 2017, 66(6):1779-1793.

[44] TAY SS, WONG YC, ROEDIGER B, et al. Intrahepatic activation of naive CD4+T cells by liver-resident phagocytic cells[J]. J Immunol, 2014, 193(5):2087-2095.

[45] BOLTJES A, van MONTFOORT N, BIESTA PJ, et al. Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function[J]. J Infect Dis, 2015, 211(8):1268-1278.

[46] HÖSEL M, QUASDORFF M, WIEGMANN K, et al. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection[J]. Hepatology, 2009, 50(6):1773-1782.

[47] LIU C, HUANG X, WERNER M, et al. Elevated expression of chemokine CXCL13 in chronic hepatitis B patients links to immune control during antiviral therapy[J]. Front Immunol,2017, 8:323.

[48] LE COUTEUR DG, COGGER VC, MARKUS AM, et al. Pseudocapillarization and associated energy limitation in the aged rat liver[J]. Hepatology, 2001, 33(3):537-543.

[49] WARREN A, LE COUTEUR DG, FRASER R, et al. T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells[J]. Hepatology, 2006, 44(5):1182-1190.

[50] CHEN M, TABACZEWSKI P, TRUSCOTT SM, et al. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin,and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway[J]. J Immunol, 2005, 175(2):1047-1055.

[51] BÉNÉCHET AP, de SIMONE G, DI LUCIA P, et al. Dynamics and genomic landscape of CD8+T cells undergoing hepatic priming[J]. Nature, 2019, 574(7777):200-205.

[52] WINAU F, HEGASY G, WEISKIRCHEN R, et al. Ito cells are liver-resident antigen-presenting cells for activating T cell responses[J]. Immunity, 2007, 26(1):117-129.

[53] YU X, LAN P, HOU X, et al. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1βproduction via suppressing the NF-κB pathway and ROS production[J]. J Hepatol, 2017, 66(4):693-702.

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Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

DOI: 10.3969/j.issn.1001-5256.2020.05.002

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Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

DOI: 10.3969/j.issn.1001-5256.2020.05.002

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