The clinical outcome of hepatitis B virus(HBV) infection mostly depends on the interaction between HBV and host immune system. Although there are still no drugs for the radical treatment of hepatitis B at present, more and more studies have found that functional cure, characterized by persistent neg...

The liver has a unique immune microenvironment, and the intrinsic antigen-presenting cells in the liver interact with each other and form a network to accurately regulate the homeostasis between liver immune tolerance and immune response. During hepatitis B virus(HBV) infection, on the one hand, the...

Host innate and adaptive immune responses are essential for the clearance of hepatitis B virus(HBV). Patients with chronic HBV infection have defects in innate and specific immune responses against HBV, which cannot effectively eliminate the virus and may result in persistent virus replication and l...

Functional cure of chronic hepatitis B(CHB) marks sustained virological inhibition and immunological control and is the ideal treatment goal recommended by the latest guidelines for the prevention and treatment of CHB in China and foreign countries. CHB patients can achieve virological inhibition wi...

Hepatitis B virus(HBV)-specific T cells in patients with chronic HBV infection are currently acknowledged as exhausted T cells. This article summarizes previous studies which support this hypothesis and then points out several inconsistencies between this hypothesis and clinical observation. Based o...

It is known that hepatitis B virus(HBV) covalently closed circular DNA(cccDNA) persists in the nucleus of infected hepatocytes in the form of minichromosome and is difficult to target and eliminate. Studies on the mechanisms and strategies for persistent silencing or elimination of HBV cccDNA are th...

In June 2017, the National Health and Family Planning Commission of the People's Republic of China issued the Guidelines for diagnosis and treatment of primary liver cancer in China(2017 edition), which is of great significance as it provides recommendations on the diagnosis, staging, and treatment ...

During the severe epidemic of coronavirus disease 2019(COVID-19) in China, some patients with chronic viral hepatitis have difficulties in attending the hospital and getting medical treatment. This article introduces the management strategies for patients with chronic viral hepatitis in medical inst...

At present, coronavirus disease 2019(COVID-19) caused by 2019 novel coronavirus(2019-nCoV) infection has spread rapidly in China and more than 70 countries around the world and thus become a public health event of international concern. In addition to fever and respiratory symptoms, varying degrees ...

Objective To investigate value of combined measurement of serum hepatitis B virus(HBV) covalently closed circular DNA(cccDNA), HBsAg, and HBV pregenomic RNA(pgRNA) in predicting the treatment outcome of HBeAg-positive chronic hepatitis B(CHB) patients treated with entecavir(ETV).Methods A total of 8...

Objective To investigate the genotype distribution of chronic hepatitis B virus(HBV) infection patients with different disease spectrums in Sichuan, China, as well as the association of genotypes with cellular immunity and coagulation function.Methods A total of543 patients with chronic HBV infectio...

Objective To investigate the association between T-lymphocyte phenotype and immune status in chronic hepatitis B(CHB)and its application value.Methods A total of 77 CHB patients who attended The First Hospital of Lanzhou University from January 2015 to May 2019 were enrolled, and according to the st...

Objective To investigate the effect of microRNA-18 a(miRNA-18 a) on the regulatory immune function in patients withchronic hepatitis B(CHB) through the PPARα/γ signaling pathway.Methods A total of 98 CHB patients and 96 patients without hepatitisB, who were treated in Air Force Special Medical Cente...

Objective To investigate the value of globulin-platelet(GP) model in the diagnosis of liver fibrosis in patients with chronic hepatitis B virus(HBV) infection and alanine aminotransferase(ALT)<2 ×upper limit of normal(ULN).Methods A retrospective analysis was performed for the clinical data of 65...

Objective To investigate the influence of different virologic responses on long-term survival rate and incidence rate of liver cancer in patients with decompensated hepatitis B cirrhosis.Methods A total of 378 patients with decompensated hepatitis B cirrhosis who were admitted to The Affiliated Hosp...

Objective To investigate the effect of hepatocyte transplantation(HCT) in the treatment of rats with liver cirrhosis and small-for-size syndrome(SFSS).Methods A total of 40 male Sprague-Dawley rats were given subcutaneous injection of carbon tetrachloride and oral administration of alcohol to establ...

Objective To investigate the changes in the diversity and structure of intestinal flora in patients with primary liver cancer after transcatheter arterial chemoembolization(TACE).Methods A total of 65 patients with primary liver cancer(among whom 20 received TACE) who were treated in The Affiliated ...

Objective To investigate the expression and clinical value of coiled-coil domain-containing protein 34(CCDC34) in hepatocellular carcinoma(HCC), and to predict the role of CCDC34 in the development and progression of HCC.Methods The datasets of HCC were downloaded from The Cancer Genome Atlas(TCGA) ...

Objective To investigate the efficacy and safety of regional citrate anticoagulation(RCA) in patients with severe liver diseasesand acute kidney injury(AKI) receiving continuous renal replacement therapy(CRRT).Methods A retrospective analysis was performedfor the medical records and first-time CRRT ...

Objective To investigate the pathological and biochemical features of each pathological subtype of bile duct injury type of drug-induced liver injury(DILI), and to verify the value and significance of pathological classification of DILI.Methods A retrospective analysis was performed for the clinical...

Objective To investigate the clinical features of patients with sepsis-induced cholestatic jaundice and the risk factors for death.Methods A retrospective analysis was performed for the clinical data of 139 patients with sepsis-induced cholestatic jaundice who were admitted to Surgical Intensive Car...

Objective To investigate the serotype and virulence genes of Klebsiella pneumoniae capsule for in-hospital liver abscess, as well as the homology of these strains.Methods A total of 26 non-repetitive strains of Klebsiella pneumoniae isolated from the patients with liver abscess in The First Affiliat...

Objective To investigate the protective effect of apigenin against H2O2-induced injury in human hepatocytes(L02).Methods L02 cells were treated with H2O2 to establish a model of oxidative injury. CCK-8 assay was used to measure cell viability; DCFH-DA was used to measure the production of reactive o...

Objective To investigate the influencing factors for stent obstruction after endoscopic retrograde biliary drainage(ERBD) forrefractory common bile duct stones.Methods A total of 126 patients who underwent ERBD for refractory common bile duct stones inRenmin Hospital of Wuhan University from January...

Objective To screen out the key intergenic long non-coding RNAs(lncRNAs) in cholangiocarcinoma(CCA) and their association with patient prognosis.Methods CCA expression and clinical data were obtained from The Cancer Genome Atlas(TCGA). High-throughput gene expression data in GSE107943 dataset were o...

Objective To investigate the association of nonalcoholic fatty liver disease( NAFLD) with the severity of acute pancreatitis(AP).Methods A total of 398 patients with AP who were admitted to The Affiliated Hospital of Southwest Medical University from January to August 2019 were enrolled, among whom ...

Objective To systematically evaluate the clinical effect of epidermal growth factor receptor( EGFR)-targeted agents in the treatment of advanced pancreatic cancer.Methods EMbase, PubMed, Cochrane Library, Clinical Trials, CNKI, Wanfang Data, and VIP were searched for randomized controlled trials(RCT...

Objective To investigate the features and clinical data of different pathological types of Vater ampullary adenocarcinoma and the influencing factors for prognosis, and to improve the prognostic evaluation and treatment outcome of Vater ampullary adenocarcinoma after surgery.Methods A retrospective ...

Patients with chronic hepatitis B virus(HBV) infection with immune control generally have no or little liver damage, with a low incidence rate of adverse events, and spontaneous HBsAg seroclearance may occur in some patients. Most scholars do not recommend antiviral therapy for such patients in Chin...

Hepatic fibrosis is a reversible pathological reaction of the liver during the self-repair of various chronic liver injuries and can progress to liver cirrhosis and liver cancer. Pyroptosis is a new type of programmed cell death different from apoptosis and necrosis and is closely associated with th...

Liver fibrosis is a chronic liver injury caused by various etiologies and a complex pathological change with the activation of hepatic stellate cells as the central link, and various signaling pathways are involved in the regulation of such complex lesions. It has the dual nature of repair and damag...

Homocysteine(Hcy) has attracted more and more attention in the medical field since it was found to be closely associated with cardiovascular and cerebrovascular diseases, hypertension, diabetes, kidney diseases, skeletal system diseases, and even mental illnesses.In recent years, the application of ...

As the prevalence rate of drug-induced liver injury increases year by year, the pathogenesis of drug-induced liver injury has become the focus of attention. As a large family, CYP450 enzymes participate in almost all oxidative metabolic reactions of drugs in the human liver. Recent studies have show...

The incidence rate of nonalcoholic fatty liver disease(NAFLD) is continuously increasing in the world, and NAFLD is a major cause of chronic liver disease in developed countries such as the United States and may become the most common chronic liver disease in China in the future. NAFLD is often obse...

The incidence rate of nonalcoholic fatty liver disease(NAFLD) is gradually increasing in recent years, and the treatment of NAFLD is unsatisfactory due to the failure in lifestyle adjustment and a lack of effective drugs. Farnesoid X receptor(FXR), as the main bile acid receptor, may affect NAFLD by...

Primary biliary cholangitis(PBC) is an autoimmune cholestatic liver disease with unknown etiology. Liver biopsy is an important diagnostic tool, but its clinical application is limited due to its invasiveness. Autoantibodies have special diagnostic and prognostic value for PBC, especially anti-mitoc...

Primary biliary cholangitis(PBC) is an chronic progressive intrahepatic cholestasis autoimmune liver disease with unknown causes, and at present, the etiology and pathogenesis of PBC remain unclear. Nuclear receptor is a ligand-dependent transcription factor superfamily that regulates cell growth an...

The incidence rate of primary liver cancer continues to increase around the world, with a younger age of onset and poorer prognosis. As the most classic regulator of cell polarity and density, mechanical signal transduction, cell proliferation, and organ development, the Hippo pathway can promote th...

As the first-line drug for the treatment of primary liver cancer, sorafenib has been widely used in clinical practice, but its drug resistance and toxic and side effects have become increasingly apparent, along with limited efficacy. In recent years, the research on regorafenib for the treatment of ...

The prognosis of hepatocellular carcinoma(HCC) is closely associated microvascular invasion(MVI), and in recent years, more and more clinical studies have been conducted on MVI, but there are few articles on the development of basic pathology and related controversies. As the basis of clinical resea...

Although hepatocellular carcinoma(HCC) is treated with a combination of multiple disciplines and methods, there are still a large number of patients with poor prognosis. Current studies have shown that microvascular invasion(MVI) is one of the important factors for poor prognosis of HCC, but MVI can...

Laparoscopic cholecystectomy is considered the gold standard for the treatment of symptomatic cholecystolithiasis and has become one of the typical representatives of minimally invasive surgery. This article briefly introduces the contraindication and indication for laparoscopic cholecystectomy, com...