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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 2
Feb.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(2): 246-251

Source and application of seed cells in bioartificial liver support system

DOI: 10.12449/JCH240205
  • 1.

    Shanghai Celliver Biotechnology Co.，Ltd.，Shanghai 201210，China

  • 2.

    Department of Anesthesiology and Critical Care Medicine，Renji Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200127，China

Research funding:

National Natural Science Foundation of China (82270635);

Shanghai 2020“Science and Technology Innovation Action Plan” Biomedical Science and Technology Support Project (20S31906600)

More Information
  • Corresponding author: YAN Hexin， hexinyw@163.com （ORCID： 0000-0001-8390-650X）
  • Received Date: 2023-10-25
  • Accepted Date: 2023-11-27
  • Published Date: 2024-02-19
    Abstract
  • So far， there are still no specific treatment methods for severe hepatitis and liver failure， resulting in a mortality rate of over 70%， and they are the difficulties in the treatment of critical illness in China and globally. Liver transplantation is currently the most effective treatment method for end-stage liver disease， but only 1%‍ ‍—‍ ‍2% of patients can receive the opportunity for organ transplantation. The bioartificial liver support system utilizes external mechanical， physical， and biological devices to remove various harmful substances accumulated in the patient’s body， compensate for the metabolic functions of the liver， supplement necessary substances， improve internal environment， promote the recovery of liver function， help patients get through the critical period， and save time for liver transplantation， and therefore， it is considered one of the important methods for the treatment of end-stage liver disease. Since hepatocytes are the core element of bioartificial liver， this article summarizes the sources of liver seed cells， 3D culture methods， and corresponding bioreactor culture systems and hopes to gradually solve the core issue of large-scale in vitro preparation of hepatocytes to obtain hepatocytes with adequate quantity and quality， which urgently needs to be addressed in clinical application.

     

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