中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

2014 No. 5

Display Method:
Editorial
Significance of clinical pathology in diagnosis and treatment of autoimmune liver diseases
Miao Qi, Ma Xiong
2014, 30(5): 385-389. DOI: 10.3969/j.issn.1001-5256.2014.05.001
Abstract:
Liver biopsy plays an important role in the diagnosis of autoimmune liver diseases, particularly in patients without specific clinical manifestations or negative for autoantibodies. The histological features of several autoimmune liver diseases are reviewed. The characteristic features of autoimmune...
Therapeutic guidelines
Expert consensus on antiviral therapy to hepatitis B/C virus-related hepatocellular carcinoma
Expert Panel of Antiviral Therapy for Hepatocellular Carcinoma
2014, 30(5): 390-395. DOI: 10.3969/j.issn.1001-5256.2014.05.002
Abstract:
Discussions by experts
Progress in diagnosis and treatment of IgG4-related hepatobiliary diseases
Li Ping, Li YongZhe
2014, 30(5): 396-399. DOI: 10.3969/j.issn.1001-5256.2014.05.003
Abstract:

IgG4- related diseases are a class of chronic, progressive, systemic inflammatory disorders that are characterized by lymphoplasmacytic inflammation, as well as elevated IgG4 levels in serum and tissue, and may involve multiple organs or tissues. When involving the pancreas, liver, and biliary tract...

Research progress in role of B cell immunity in primary biliary cirrhosis
Tan YanGuo, Yan HuiPing, Gao ZuHua
2014, 30(5): 400-404. DOI: 10.3969/j.issn.1001-5256.2014.05.004
Abstract:

Primary biliary cirrhosis ( PBC) is characterized by injury of small intrahepatic bile ducts, but its mechanism, especially the role of B cell immunity in this disease, remains unclear. The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the following aspects: distributi...

Original articles_Autoimmune liver disease
Analysis of clinical significance of combined antigen screening reagents for autoimmune liver disease
Sun LiMei, Zhao YanMing, Wang YiPeng, Zhao DanTong, Zhang HaiPing, Li ZhuoMin, Wang Yi, Ma YinXue, Yan HuiPing, Liu YanMin
2014, 30(5): 405-408. DOI: 10.3969/j.issn.1001-5256.2014.05.005
Abstract:

Objective To investigate the clinical significance of combined antigen screening reagents for autoimmune liver disease ( AILD) . Methods A total of 140 patients with liver diseases who visited the Beijing You'an Hospital affiliated to Capital Medical University from September 2011 to September 2012,...

Changes in frequencies of peripheral blood lymphocyte subsets and their clinical significance in patients with autoimmune liver diseases
Li YuanYuan, Wang LiFeng, Geng Hua, Yu ShuangJie, Lin Hu, Lu: Sa, Chen LiMing, Zhang Zheng, Wang FuSheng
2014, 30(5): 409-412. DOI: 10.3969/j.issn.1001-5256.2014.05.006
Abstract:

Objective To investigate the changes in frequencies of peripheral blood lymphocyte ( PBL) subsets and their clinical significance in patients with primary biliary cirrhosis ( PBC) , autoimmune hepatitis ( AIH) , and AIH- PBC overlap syndrome. Methods Forty- one patients with AIH- PBC overlap syndrom...

Clinical features and diagnosis of autoimmune hepatitis-primary biliary cirrhosis overlap syndrome
Li Bing, Shao Qing, Niu XiaoXia, Zhang Jian, Chen GuoFeng
2014, 30(5): 413-416. DOI: 10.3969/j.issn.1001-5256.2014.05.007
Abstract:

Objective To analyze the clinical features and laboratory test results of patients with autoimmune hepatitis ( AIH) - primary biliary cirrhosis ( PBC) overlap syndrome, as well as their correct diagnosis rate and time to diagnosis. Methods Fifty- three patients who were diagnosed by liver biopsy as ...

Clinical value of serum soluble intercellular adhesion molecule-1 in patients with primary biliary cirrhosis and autoimmune hepatitis
Ye Qing, Han Tao, Li Ning
2014, 30(5): 417-420. DOI: 10.3969/j.issn.1001-5256.2014.05.008
Abstract:

Objective To investigate the clinical value of serum soluble intercellular adhesion molecule- 1 ( sICAM- 1) in patients with primary biliary cirrhosis ( PBC) and autoimmune hepatitis ( AIH) . Methods Sixty- one PBC patients and 59 AIH patients, who were hospitalized or visited the outpatient departm...

Original articles_Viral hepatitis
Correlation between HBV DNA load and ALT level: analysis of 800 patients with chronic hepatitis B
Feng GuangShuai, Pan Ling, Feng QuanSheng
2014, 30(5): 421-423. DOI: 10.3969/j.issn.1001-5256.2014.05.009
Abstract:
Objective To analyze the relationship between hepatitis B virus ( HBV) DNA load and serum alanine aminotransferase ( ALT) level and to investigate the reason that ALT level changes in patients with HBV infection. Methods ALT level ( dependent variable) and HBV DNA load ( independent variable) were s...
Diagnostic value of FibroTest combined with FibroScan for liver fibrosis in patients with chronic hepatitis B
Cheng XiaoJing, Lu Wei, Hou Wei, Wang ChunYan, Liu YongGang, Wang JinSheng, Meng Chao
2014, 30(5): 424-427. DOI: 10.3969/j.issn.1001-5256.2014.05.010
Abstract:

Objective To investigate the diagnostic value of FibroTest combined with FibroScan for liver fibrosis in patients with chronic hepatitis B ( CHB) . Methods Serum samples were collected from 99 CHB patients who underwent liver biopsy in Tianjin Second People's Hospital from August 2011 to July 2013. ...

Original articles_Biliary diseases
Clinical efficacy of sequentially used duodenal endoscope electronic choled ochoscope and laparoscope in treatment of choledocholithiasis with gallbladder stones:  report of 834 cases
Zhang Lei, Song XiaoJing, Zhou WenCe, Zhu KeXiang, Zhu XiaoLiang, Meng WenBo, Li Xun
2014, 30(5): 428-430. DOI: 10.3969/j.issn.1001-5256.2014.05.011
Abstract:

Objective To investigate the clinical efficacy of sequentially used duodenal endoscope electronic choled ochoscope and laparoscope in the treatment of choledocholithiasis with gallbladder stones. Methods A retrospective analysis was performed on 834 patients with choledocholithiasis and gallbladder ...

Laparoscopic cholecystectomy for high-risk cholecystolithiasis: surgical key points and analysis of 115 cases
Huang Hui, Dui DanHua, Cai ZhiFang
2014, 30(5): 431-433. DOI: 10.3969/j.issn.1001-5256.2014.05.012
Abstract:

Objective To investigate the characteristics of high- risk cholecystolithiasis and summarize the experience of laparoscopic cholecystectomy for this disease. Methods A retrospective analysis was performed on the clinical data of 115 patients with high- risk cholecystolithiasis who underwent laparosc...

Original articles_Others
Clinical effect of albumin dialysis combined with plasma perfusion in treatment of liver failure
Wu ShaoHong, Gan JianHe, Huang XiaoPing, Lin Hua, Lu NianFang, Wu JiangQuan, Zheng RuiQiang
2014, 30(5): 434-437. DOI: 10.3969/j.issn.1001-5256.2014.05.013
Abstract:

Objective To evaluate the safety and clinical effect of albumin dialysis combined with plasma perfusion in the treatment of liver failure. Methods Seventeen patients with liver failure were treated with albumin dialysis combined with plasma perfusion from January 2010 to April 2012. The treatment ou...

Clinical characteristics of drug-induced liver injury: an analysis of 394 cases
Qi YaBin, Qiu Ling, Jiang HongLi, Zhang Rui, Hu YuLin
2014, 30(5): 438-441. DOI: 10.3969/j.issn.1001-5256.2014.05.014
Abstract:

Objective To analyze the clinical characteristics of drug- induced liver injury ( DILI) . Methods A retrospective analysis was performed on the clinical data of 394 patients with DILI who were admitted to our hospital from 2009 to 2011. The studied factors included age, sex, names and categories of ...

Construction of specific interference vector and lentiviral packaging for SMAC gene in mice
Wu Fan, Yi ZaiFeng, Tian DeYing
2014, 30(5): 442-445. DOI: 10.3969/j.issn.1001-5256.2014.05.015
Abstract:

Objective To construct and identify the specific interference vector for second mitochondria- derived activator of caspase ( SMAC) gene in mice and perform lentiviral packaging. Methods According to the SMAC gene sequences in mice, three small interfering RNAs ( siRNAs) ( siRNA1, siRNA2, and siRNA3)...

Brief reports
Analysis of application of anti-HBV nucleos(t)ide analogues
Yang WeiMin, Xin GuiJie, Li YanYan
2014, 30(5): 446-448. DOI: 10.3969/j.issn.1001-5256.2014.05.016
Abstract:
Case reports
Three cases of drug-induced autoimmune hepatitis
Lu Jun
2014, 30(5): 449-450. DOI: 10.3969/j.issn.1001-5256.2014.05.017
Abstract:
Autoimmune hepatitis and cirrhosis with splenic infarction and cerebral infarction: a report of one case
Wang XiaoLin, Chen XiuJi
2014, 30(5): 451-452. DOI: 10.3969/j.issn.1001-5256.2014.05.018
Abstract:
Hypothyroidism characterized by abnormal liver function: a clinical analysis of 4 cases
Yin FengRong
2014, 30(5): 453-454. DOI: 10.3969/j.issn.1001-5256.2014.05.019
Abstract:
Primary systemic amyloidosis: a report of one case
Liu SuYing, Liu Fei, Ji HuiFan, Zhang GuoShan, Guo XiaoLin
2014, 30(5): 455-457. DOI: 10.3969/j.issn.1001-5256.2014.05.020
Abstract:
Reviews
Basic and clinical progress in autoimmune liver disease
Zhang LingJuan, Gu ChunYu, Xu Jia, Ma JingTing, Li DongFu
2014, 30(5): 458-461. DOI: 10.3969/j.issn.1001-5256.2014.05.021
Abstract:

Autoimmune liver disease ( AILD) is substantially different from common liver diseases, and it is very important to improve its recognition and diagnostic level. The literature on AILD published in recent years is reviewed, and the advances in pathogenesis, autoantibodies, diagnosis, and treatment o...

Research progress in medical treatment of primary biliary cirrhosis
Wang Qian, Yao DingKang
2014, 30(5): 462-465. DOI: 10.3969/j.issn.1001-5256.2014.05.022
Abstract:

Primary biliary cirrhosis ( PBC) is an autoimmune disease. Ursodeoxycholic acid ( UDCA) is the only safe and effective drug for the treatment of PBC, as proved by randomized controlled clinical trials, so it is advocated as first- line therapy. Alternative therapies are urgently needed for patients ...

Significance of serum anti-gp210 antibody detection in diagnosis of primary biliary cirrhosis
Li YinPing, Niu JunQi
2014, 30(5): 466-468. DOI: 10.3969/j.issn.1001-5256.2014.05.023
Abstract:

Primary biliary cirrhosis ( PBC) is a chronic disease characterized by progressive destruction of intrahepatic small bile ducts, which may progress to liver cirrhosis. Anti- mitochondrial antibodies, especially anti- M2 antibody, have a high diagnostic value for PBC, but they are unrelated to the se...

Research progress in liver targeted therapy for nonalcoholic fatty liver disease
Jin XueYuan, Wang HuiFen
2014, 30(5): 469-472. DOI: 10.3969/j.issn.1001-5256.2014.05.024
Abstract:

Nonalcoholic fatty liver disease ( NAFLD) is the most common progressive liver disease worldwide. Currently, there is no satisfying treatment for NAFLD. Research progress in fatty acid bile acid conjugates ( FABACs) and ursodeoxycholyl lysophosphatidylethanolamide ( UDCA- LPE) , which are two novel ...

Research progress in liver-specific miR-122 in regulating liver diseases
Yang YingZhuo, Kang Peng, Gao Jie, Xu ChunLin, Wang ShiMei, Wu Xia
2014, 30(5): 473-477. DOI: 10.3969/j.issn.1001-5256.2014.05.025
Abstract:

MicroRNA- 122 ( miR- 122) , a liver- specific microRNA, has important functions in the physiological function and disease development of the liver. The association of miR- 122 with steatohepatitis and its possible action mechanism are described, and the effects of altered miR- 122 expression in regu...

Treatment of hepatitis: a summary of APASL Annual Meeting 2014
Luo ShengQiang, Wang Bin
2014, 30(5): 478-480. DOI: DOI: 10.3969/j.issn.1001-5256.2014.05.026
Abstract: