2014 No. 6

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Editorial

The challenges to hepatitis C research in era of direct antiviral agents

Zhong Jing, Tao WanYin

2014, 30(6): 481-484. DOI: 10.3969/j.issn.1001-5256.2014.06.001

Abstract(2553)

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Abstract:
Hepatitis C virus ( HCV) is an important human pathogen that causes chronic viral hepatitis worldwide. HCV infection, often persistent and asymptomatic, could lead to liver fibrosis /cirrhosis and hepatocellular carcinoma. The interferon /ribavirin therapy has been widely used for treating chronic h...

Therapeutic guidelines

EASL recommendations on treatment of Hepatitis C 2014 (April 2014)

Liu HongHong, Luo ShengQiang

2014, 30(6): 1-6. DOI: 10.3969/j.issn.1001-5256.2014.06.026

Abstract(264)

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Abstract:

Evaluation for liver transplantation in adults: 2013 Practice Guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation

Zhou Xia, Zhang Min

2014, 30(6): 7-9. DOI: 10.3969/j.issn.1001-5256.2014.06.027

Abstract(320)

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Abstract:

Discussions by experts

Re- understanding of refractory hepatitis C: progress in antiviral therapy strategies for hepatitis C

Dou XiaoGuang, Ding Yang

2014, 30(6): 485-488. DOI: 10.3969/j.issn.1001-5256.2014.06.002

Abstract(330)

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Abstract:
It has been nearly 20 years from the discovery of hepatitis C virus ( HCV) and clinical diagnosis of hepatitis C to antiviral therapy with interferon, and significant progress has been made. Substantial changes have taken place in both the concept and strategy for antiviral treatment of hepatitis C,...

Diagnosis and treatment of acute hepatitis C

Zhao Ning, Li ZhiWei

2014, 30(6): 489-492. DOI: 10.3969/j.issn.1001-5256.2014.06.003

Abstract(3154)

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Abstract:
Acute hepatitis C is an acute infectious disease caused by hepatitis C virus. Accurate diagnosis and proper treatment are very important for preventing the progression of this disease. Recent research advances in acute hepatitis C, including the epidemiological and clinical features, diagnosis, and ...

Recent progress in direct- acting antiviral agents for chronic hepatitis C

Li MinRan, Xu XiaoYuan

2014, 30(6): 493-495. DOI: 10.3969/j.issn.1001-5256.2014.06.004

Abstract(2942)

PDF (1157KB)(717)

Abstract:
The current standard treatment for hepatitis C virus ( HCV) infection is a combination of pegylated interferon ( PEG- IFN) and ribavirin. However, it remains incurable in some patients. In recent years, direct acting antiviral agents ( DAAs) that target specific HCV enzymes in HCV life cycle have be...

Original articles_Viral hepatitis

Association between serum lipid levels and antiviral treatment outcome in patients with chronic hepatitis C

Shi Jia, Shen Zhen, Miao Hui, Yang ZongGuo, Xu QingNian, Lu YunFei, Lyu Ying, Chen XiaoRong

2014, 30(6): 496-500. DOI: 10.3969/j.issn.1001-5256.2014.06.005

Abstract(3290)

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Abstract:

Objective To investigate the association between serum lipid levels and antiviral treatment outcome in chronic hepatitis C ( CHC) patients. Methods A total of 171 treatment-naive CHC patients were included in the present retrospective study and received a standard therapy of pegylated interferon ( P...

Effect of HCV on disease progression in patients with HIV /HCV coinfection

Liu JinHua, Zhao Yan, Sun HuanQin, Liu Ning, Qiao GuiFang, Wang ZiKang, Xu Jie, Li Ang, Zhang YongHong

2014, 30(6): 501-504. DOI: 10.3969/j.issn.1001-5256.2014.06.006

Abstract(3240)

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Abstract:
Objective To analyze the effect of hepatitis C virus ( HCV) on disease progression in patients with human immunodeficiency virus ( HIV) /HCV coinfection. Methods Twenty- nine patients with HIV /HCV coinfection and 20 patients with HIV infection alone, who visited Beijing YouAn hospital for follow- u...

Epidemiological features and disease spectrum of hepatitis C in Qinghai Province, China: analysis of 110 cases

Huang YanWu, Han FengJuan

2014, 30(6): 505-507. DOI: 10.3969/j.issn.1001-5256.2014.06.007

Abstract(3002)

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Abstract:
Objective To investigate the epidemiological features and disease spectrum of inpatients with hepatitis C in recent years and to provide reference for the control of hepatitis C. Methods A retrospective study of demography, epidemiology, and laboratory examination was performed in 110 hospitalized p...

Changes in NK cells and regulatory T cells among patients with refractory chronic hepatitis C during antiviral treatment

Chen XiaoYun, Zhang YongHong, Ma LiNa, Jin Yi, Yu HaiBin, Zheng YanHong, Liu Ning, Liu JinHua, Wang Jian, Chen XinYue

2014, 30(6): 508-513. DOI: 10.3969/j.issn.1001-5256.2014.06.008

Abstract(3243)

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Abstract:
Objective To investigate the changes in NK cells and regulatory T ( Treg) cells among patients with refractory chronic hepatitis C ( CHC) during antiviral therapy and to analyze antiviral effect-related immunological factors. Methods A total of 41 patients with refractory CHC ( 30 treatment- naive p...

Relationship between IL- 28B polymorphisms and susceptibility to hepatitis C among Han population in Jiangsu Province, China

Tan GuoLei, Sun Mei, Wang JianFang, Wu XuPing

2014, 30(6): 514-517. DOI: 10.3969/j.issn.1001-5256.2014.06.009

Abstract(2973)

PDF (1166KB)(599)

Abstract:
Objective To investigate the association between interleukin- 28B ( IL- 28B) polymorphisms and susceptibility to hepatitis C among the Han population in Jiangsu Province, China. Methods A case- control study was conducted in 88 hepatitis C patients who visited the Second Hospital of Nanjing in 2011 ...

Construction of lentiviral vector encoding CLEC4M and overexpression of CLEC4M in K- 562 cells

Wang YuanYuan, Nie QingHe, Zhu Ting

2014, 30(6): 518-521. DOI: 10.3969/j.issn.1001-5256.2014.06.010

Abstract(3659)

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Abstract:
Objective To construct the lentiviral vector encoding CLEC4M and prepare K- 562 cells with stable overexpression of CLEC4M. Methods The gene sequence of normal CLEC4M was cloned by reverse transcription PCR and then inserted into GV166 vector to construct GV166- CLEC4M lentiviral expression vector, ...

Changes in serum levels of Th1 /Th2 cytokines in HBeAg- positive pregnant women with HBV infection after telbivudine treatment

Huang HongFei, He DengMing, Wu QuanXin, Li MaoShi, Zhu Peng, Wang YuMing

2014, 30(6): 522-526. DOI: 10.3969/j.issn.1001-5256.2014.06.011

Abstract(2247)

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Abstract:
Objective To evaluate the changes in serum levels of Th1 /Th2 cytokines in pregnant women with chronic hepatitis B virus ( HBV) infection after telbivudine treatment and to investigate the immune mechanism by which telbivudine blocks the mother- to- infant transmission of HBV. Methods Fifty- four HB...

Clinical significance of low- level HBV DNA replication and specific antibody expression in patients with HBV- related liver failure

Tian FangYuan, Dan Jing, Tang KuanYin, Cao WuKui

2014, 30(6): 527-530. DOI: 10.3969/j.issn.1001-5256.2014.06.012

Abstract(2957)

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Abstract:
Objective To investigate the influential factors and clinical significance of low- level hepatitis B virus ( HBV) DNA replication and specific antibody expression in patients with HBV- related liver failure. Methods A retrospective analysis was performed on the medical records of 391 patients with H...

Study of HBV- X gene mutation among patients with HBV- related chronic hepatitis, liver cirrhosis, and primary liver cancer

Lei Man, He Song

2014, 30(6): 531-536. DOI: 10.3969/j.issn.1001-5256.2014.06.013

Abstract(2567)

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Abstract:
Objective To study the relationship between hepatocarcinogenesis and the mutation in X gene among patients with chronic hepatitis B virus ( HBV) infection, such as chronic hepatitis B ( CHB) , liver cirrhosis ( LC) and primary liver cancer ( PLC) . Methods The serum samples from 89 patients with chr...

Efficacy of magnesium isoglycyrrhizinate in treatment of hepatitis E with severe jaundice

Luo XiaoKe, Li XiaoLing, Yang LiMing, Wang XiaoHong

2014, 30(6): 537-539. DOI: 10.3969/j.issn.1001-5256.2014.06.014

Abstract(2411)

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Abstract:
Objective To observe and analyze the efficacy of magnesium isoglycyrrhizinate in the treatment of hepatitis E with severe jaundice. Methods Seventy- eight cases of hepatitis E with severe jaundice admitted from January 2009 to December 2012 were equally divided into treatment group ( n = 39) and con...

Original articles_Liver fibrosis and liver cirrhosis

Analysis of risk factors for early rebleeding from esophageal and gastric varices in patients with liver cirrhosis

Yang Hua, Liu YunXia, Li Peng, Yang ShaoQi, Wang YuanZhen

2014, 30(6): 540-542. DOI: 10.3969/j.issn.1001-5256.2014.06.015

Abstract(384)

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Abstract:

Objective To investigate the risk factors for early rebleeding from esophageal and gastric varices ( EGV) in patients with liver cirrhosis. Methods A total of 432 patients with liver cirrhosis who were admitted to Ningxia Medical University from January 2006 to December 2009 were included in the stu...

Original articles_Biliary diseases

Diagnostic values of ultrasonography and CT for gallbladder adenomyomatosis: a comparative analysis

Zhang QinQin, Chen Fei, Qiu ShaoDong

2014, 30(6): 543-545. DOI: 10.3969/j.issn.1001-5256.2014.06.016

Abstract(2609)

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Abstract:
Objective To analyze the diagnostic values of ultrasonography and computed tomography ( CT) for gallbladder adenomyomatosis.Methods The ultrasound and CT findings of 28 cases of pathologically confirmed gallbladder adenomyomatosis in our hospital were retrospectively analyzed. The diagnostic values ...

Clinical study of changes in intestinal permeability in patients with gallstones of different distribution and properties

Bai ShunYan, Xiao SiJie, Wei Na

2014, 30(6): 546-548. DOI: 10.3969/j.issn.1001-5256.2014.06.017

Abstract(2826)

PDF (1156KB)(526)

Abstract:
Objective To study the changes in intestinal permeability in patients with gallstones of different distribution and properties and to investigate the role of intestinal barrier function in gallstone formation. Methods A total of 108 patients with gallstones in our hospital in need of operation from ...

Original articles_Pancreatic diseases

Early changes in hemorheological parameters and TXA2 and PGI2 levels among patients with severe acute pancreatitis

Liang Chao, Sha YingYing, Zhu XiaoMing, Wang XiongDa, Zhu YuHua, Zhao ZhenYu

2014, 30(6): 549-551. DOI: 10.3969/j.issn.1001-5256.2014.06.018

Abstract(2571)

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Abstract:
Objective To investigate the early changes in hemorheological parameters and thromboxane A2 ( TXA2) and prostacyclin ( PGI2) levels among patients with severe acute pancreatitis ( SAP) . Methods Thirty-two SAP patients hospitalized from January 2012 to September 2013 were selected as SAP group; 30 h...

Original articles_Hepatopancreatobiliary tumor

Clinical value of laparoscopic hepatectomy in liver cancer patients with cirrhosis

Xu JunHui, Ding YouMing, Wang Bin, Fang HanGang

2014, 30(6): 552-555. DOI: 10.3969/j.issn.1001-5256.2014.06.019

Abstract(2737)

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Abstract:

Objective To compare the perioperative outcomes of laparoscopic hepatectomy ( LH) versus open hepatectomy ( OH) for liver cancer patients with cirrhosis. Methods From September 2010 to June 2012, 78 liver cancer patients with cirrhosis hospitalized in Renmin Hospital affiliated to Wuhan University w...

Changes in platelet parameters and their influential factors in cirrhotic patients with hepatocellular carcinoma

Ding ShengNan, Yang WeiMin, Niu JunQi

2014, 30(6): 556-559. DOI: 10.3969/j.issn.1001-5256.2014.06.020

Abstract(3300)

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Abstract:

Objective To analyze the changes in platelet parameters and their influential factors in cirrhotic patients with hepatocellular carcinoma ( HCC) . Methods The clinical data of 602 cirrhotic patients with HCC who were admitted to the First Hospital of Jilin University from January 2011 to December 20...

Original articles_Others

Diagnosis and treatment of hepatogenous diarrhea: an analysis of 62 cases

Bao SuXia, Sun ZhangYu, Zhou Yan, Zhang ZhiHao, Dun ShaoZhi, Wang YingYing, Chen Si, Yang XiaoYan

2014, 30(6): 560-562. DOI: 10.3969/j.issn.1001-5256.2014.06.021

Abstract(4266)

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Abstract:

Objective To investigate the pathogenesis, diagnostic keys, and treatment of hepatogenous diarrhea. Methods Sixty- two patients with hepatogenous diarrhea were assigned to three levels of treatment. Patients given level- one treatment received live combined Clostridium butyricum and Bifidobacterium ...

Clinical efficacy of magnesium isoglycyrrhizinate in treatment of liver injury among patients with obstructive jaundice after percutaneous transhepatic cholangiodrainage

Wang XiaoPeng, Su He, Tian HongWei, Zhang SuYu, Wu ZiYan, An YaLi, Ma YunTao

2014, 30(6): 563-566. DOI: 10.3969/j.issn.1001-5256.2014.06.022

Abstract(2957)

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Abstract:

Objective To evaluate the clinical efficacy and safety of magnesium isoglycyrrhizinate in the treatment of liver injury among patients with obstructive jaundice after percutaneous transhepatic cholangiodrainage ( PTCD) . Methods Sixty- two obstructive jaundice patients with liver injury after PTCD w...

Case reports

One case of adult Still's disease with fever and jaundice as main clinical manifestations

Zhang Kai, Chen Hong, Lu MingXia, Wang FeiFei, Wan Hui, Zhang LiTing

2014, 30(6): 567-568. DOI: 10.3969/j.issn.1001-5256.2014.06.023

Abstract(2700)

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Abstract:

Reviews

Research progress in HBV /HCV co- infection

He Li, Hu Ping, Shen HuanJun, Zhang Ye, Huang ZhangXing

2014, 30(6): 569-572. DOI: 10.3969/j.issn.1001-5256.2014.06.024

Abstract(3105)

PDF (1172KB)(750)

Abstract:
Hepatitis B virus ( HBV) is a hepatotropic DNA virus; HBV DNA and special P protein are covered by capsid proteins to form core particles, which are then covered by lipoprotein to form complete virus particles. Hepatitis C virus ( HCV) , which belongs to the Flaviviridae family, is a single- strande...

Research progress in tumor- associated antigen antibodies for diagnosis of liver cancer

Wang WuChen, Zhou YongNing

2014, 30(6): 573-576. DOI: 10.3969/j.issn.1001-5256.2014.06.025

Abstract(2992)

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Abstract:
Liver cancer is one of the most common malignant tumors in the world. The mortality of patients with liver cancer remains high even with increasing progress in therapies. Early diagnosis is helpful for prolonging the survival of patients, so new biomarkers need to be explored for timely diagnosis an...