146例儿童肝功能异常的病因分析

王红玉; 吴捷

doi:10.3969/j.issn.1001-5256.2020.11.024

146例儿童肝功能异常的病因分析

DOI: 10.3969/j.issn.1001-5256.2020.11.024

王红玉,
吴捷

中国医科大学附属盛京医院小儿消化内科

详细信息

中图分类号: R725.7
计量
- 文章访问数: 524
- HTML全文浏览量: 18
- PDF下载量: 108
- 被引次数: 0
出版历程
- 出版日期: 2020-11-20

Causes of abnormal liver function in children:An analysis of 146 cases

WANG HongYu,
WU Jie

Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University

摘要

摘要:
<正>肝脏是人类的重要器官之一,儿童期由于身体各个器官尚未发育完善,受到病原菌感染、接触有害化学物质、使用药物等因素后容易累及肝脏出现临床症状或肝功能异常。肝功能异常指肝脏受到某些致病因素损害,引起肝脏功能代谢及形态结构发生了异常。近年来因肝功能异常入院患儿逐渐增多,不同病因的治疗及预后存在差异。本文主要通过收集以肝功能异常为主诉就诊的住院患儿资料,回顾性分析引起学龄期及初入青春期儿童肝功能异常的病因。
- 肝功能异常 /
- 儿童 /
- 病因
- abnormal liver function /
- child /
- etiology

HTML全文

参考文献(24)

[1] ZHOU XL,FU JF. Expert consensus on the diagnosis and treatment of nonalcoholic fatty liver disease in children[J].Chin J Pract Pediatr,2018,33(7):487-492.(in Chinese)周雪莲，傅君芬．儿童非酒精性脂肪肝病诊断与治疗专家共识[J]．中国实用儿科杂志，2018,33(7):487-492.

[2] Drug-induced Liver Disease Study Group,Chinese Society of Hepatology,Chinese Medical Association. Guidelines for the management of drug-induced liver injury[J]. J Clin Hepatol,2015,31(11):1752-1769.(in Chinese)中华医学会肝病学分会药物性肝病学组．药物性肝损伤诊治指南[J]．临床肝胆病杂志，2015,31(11):1752-1769.

[3] SOCHA P,JANCZYK W,DHAWAN A,et al. Wilson’s disease in children:A position paper by the Hepatology Committee of the European Society for Paediatric Gastroenterology,Hepatology and Nutrition[J]. J Pediatr Gastroenterol Nutr,2018,66(2):334-344.

[4] GILBERT MA,BAUER RC,RAJAGOPALAN R,et al. Alagille syndrome mutation update:Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification[J]. Hum Mutat,2019,40(12):2197-2220.

[5] Neurology Branch of Chinese Medical Association; Study Group of Neuromuscular Diseases,Neurology Branch of Chinese Medical Association; Study Group of Electromyography and Clinical Neurophysiology,Neurology Branch of Chinese Medical Association. Chinese guidelines for the diagnosis and treatment of pseudohypertrophic muscular dystrophy[J]. Chin J Neurol,2016,49(1):17-20.(in Chinese)中华医学会神经病学分会，中华医学会神经病学分会神经肌肉病学组，中华医学会神经病学分会肌电图与临床神经生理学组．中国假肥大型肌营养不良症诊治指南[J]．中华神经科杂志，2016,49(1):17-20.

[6] DAGLI A,SENTNER CP,WEINSTEIN DA. Glycogen storage disease typeⅢ[M]. In:GeneReviews[Internet]. Seattle(WA):University of Washington,Seattle; 1993-2020.

[7] SCIVERES M,NASTASIO S,MAGGIORE G. Novel diagnostic and therapeutic strategies in juvenile autoimmune hepatitis[J]. Front Pediatr,2019,7:382.

[8] Study Group of Thrombosis and Hemostasis,Chinese Society of Hematology,Chinese Medical Association; Study Group of Children,Hemophilia Treatment Center Collaborative Network of China; Study Group of Hematology,Chinese Pediatric Society,Chinese Medical Association. Chinese expert guidelines for hemophilia in children(2017)[J]. Chin J Pract Pediatr,2017,32(1):1-5.(in Chinese)中华医学会血液学分会血栓与止血学组，中国血友病协作组儿童组，中华医学会儿科学分会血液学组．中国儿童血友病专家指导意见(2017年)[J]．中国实用儿科杂志，2017,32(1):1-5.

[9] GREEN RM,FLAMM S. AGA technical review on the evaluation of liver chemistry tests[J]. Gastroenterology,2002,123(4):1367-1384.

[10] WANG G,FENG D. Dynamic relationship between infantile hepatitis syndrome and cytomegalovirus infection[J]. Exp Ther Med,2017,13(6):3443-3447.

[11] SOHN MJ,CHO JM,MOON JS,et al. EBV VCA IgM and cytomegalovirus IgM dual positivity is a false positive finding related to age and hepatic involvement of primary Epstein-Barr virus infection in children[J]. Medicine(Baltimore),2018,97(38):e12380.

[12] KOFTERIDIS DP,KOULENTAKI M,VALACHIS A,et al. Epstein Barr virus hepatitis[J]. Eur J Intern Med,2011,22(1):73-76.

[13] HEROLD J,GRIMALDO F. Epstein-Barr virus-induced jaundice[J]. Clin Pract Cases Emerg Med,2020,4(1):69-71.

[14] PODDIGHE D. Extra-pulmonary diseases related to Mycoplasma pneumoniae in children:Recent insights into the pathogenesis[J]. Curr Opin Rheumatol,2018,30(4):380-387.

[15] KIM KW,SUNG JJ,TCHAH H,et al. Hepatitis associated with Mycoplasma pneumoniae infection in Korean children:A prospective study[J]. Korean J Pediatr,2015,58(6):211-217.

[16] CLEMENTE MG,MANDATO C,POETA M,et al. Pediatric non-alcoholic fatty liver disease:Recent solutions,unresolved issues,and future research directions[J]. World J Gastroenterol,2016,22(36):8078-8093.

[17] WANG FS,FAN JG,ZHANG Z,et al. The global burden of liver disease:The major impact of China[J]. Hepatology,2014,60(6):2099-2108.

[18] CUZMAR V,ALBERTI G,UAUY R,et al. Early obesity:Risk factor for fatty liver disease[J]. J Pediatr Gastroenterol Nutr,2020,70(1):93-98.

[19] ZHANG HF,DONG Y,WANG LM,et al. A retrospective study on pathological and clinical characteristics of 3 932 children with liver diseases[J]. Chin J Pediatr,2014,52(8):570-574.(in Chinese)张鸿飞，董漪，王丽旻，等．儿童肝穿刺组织病理与临床诊断3932例回顾性研究[J]．中华儿科杂志，2014,52(8):570-574.

[20] CHUGHLAY MF,KRAMER N,SPEARMAN CW,et al. Nacetylcysteine for non-paracetamol drug-induced liver injury:A systematic review[J]. Br J Clin Pharmacol,2016,81(6):1021-1029.

[21] YANG LX,LIU CY,ZHANG LL,et al. Clinical characteristics of patients with drug-induced liver injury[J]. Chin Med J(Engl),2017,130(2):160-164.

[22] ZHANG YF,GUO YM,NIU M,et al. Drug-induced liver injury in children:An analysis of medication and clinical features[J]. J Clin Hepatol,2019,35(3):579-584.(in Chinese)张艳芳，郭玉明，牛明，等．儿童药物性肝损伤的用药分析及临床特征[J]．临床肝胆病杂志，2019,35(3):579-584.

[23] ZHU XX,ZHU Y,WAN CM. Clinical features of drug-induced liver injury in children[J]. Chin J Contemp Pediatr,2012,14(2):131-133.(in Chinese)朱欣欣，朱渝，万朝敏．儿童药物性肝损害的临床研究[J]．中国当代儿科杂志，2012,14(2):131-133.

[24] GAN Y,DONG Y,ZHANG HF,et al. Clinical characteristics and outcomes of drug-induced liver injury in children:A study of 184 cases[J]. J Clin Hepatol,2015,31(8):1244-1247.(in Chinese)甘雨，董漪，张鸿飞，等．184例儿童药物性肝损伤的临床特征及转归状况评价[J]．临床肝胆病杂志，2015,31(8):1244-1247.

施引文献

资源附件(0)

访问统计