单核细胞趋化蛋白-1及其受体在肝纤维化进程中的作用

郭悦承; 陆伦根

doi:10.3969/j.issn.1001-5256.2019.12.032

单核细胞趋化蛋白-1及其受体在肝纤维化进程中的作用

DOI: 10.3969/j.issn.1001-5256.2019.12.032

上海市第一人民医院消化科

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中图分类号: R575.2
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出版历程
- 收稿日期: 2019-07-11
- 出版日期: 2019-12-20

Role of monocyte chemoattractant protein 1 and its receptor in the progression of liver fibrosis

Department of Gastroenterology,Shanghai General Hospital

摘要

摘要: 肝纤维化是慢性肝损伤共有的可逆性病理改变,有进展为肝硬化、肝衰竭、门静脉高压的可能。近年来,多项研究指出,肝纤维化患者趋化因子谱发生显著变化,并且与肝纤维化的进展密切相关。单核细胞趋化蛋白-1（MCP-1）属于CC趋化因子家族,在肝纤维化进程中可发挥激活、募集、迁移炎症细胞的作用,并可能参与肝星状细胞（HSC）的激活、胰岛素抵抗（IR）的形成以及肝细胞癌（HCC）的进展。主要介绍了MCP-1及CC趋化因子受体（CCR） 2在肝纤维化发展中的可能作用以及相关疗法的最新进展。
- 单核细胞化学吸引蛋白质类 /
- 受体,CCR2 /
- 肝硬化 /
- 巨噬细胞
Abstract: Liver fibrosis is a common reversible pathological change in chronic liver injury and may progress to liver cirrhosis,liver failure,and portal hypertension. In recent years,several studies have shown a significant change in chemokine profiles in patients with liver fibrosis,which is closely associated with the progression of liver fibrosis. Monocyte chemoattractant protein 1( MCP-1) belongs to the family of CC chemokines and can induce the activation,recruitment,and migration of inflammatory cells during liver fibrosis. MCP-1 may be involved in the activation of hepatic stellate cells,the development of insulin resistance,and the progression to hepatocellular carcinoma. This article mainly reviews the potential role of MCP-1 and CC chemokine receptor in the progression of liver fibrosis and related therapies.
- monocyte chemoattractant protein /
- receptors,CCR2 /
- liver cirrhosis /
- macrophages

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参考文献(33)

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