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药物性胆汁淤积的发病机制及诊疗现状

刘梦 杨玄子 于乐成

引用本文:
Citation:

药物性胆汁淤积的发病机制及诊疗现状

DOI: 10.3969/j.issn.1001-5256.2019.02.003
详细信息
  • 中图分类号: R575

Current status of the pathogenesis, diagnosis, and treatment of drug-induced cholestasis

  • 摘要:

    药物性胆汁淤积(DRIC)主要包括胆汁淤积型药物性肝损伤和混合型药物性肝损伤,其诊断应参考RUCAM量表判断药物与胆汁淤积之间的因果关系,尤其是充分排除其他病因。肝活组织病理学检查有助于鉴别诊断。发生DRIC后通常应及时停药和避免再刺激,并给予熊去氧胆酸等药物治疗。DRIC发病机制复杂,涉及药物及其代谢产物对肝细胞和胆管树的直接毒性、免疫和炎症反应、药物代谢与外排通路中酶和转运载体的受抑及基因多态性、HLA基因多态性等。深入阐明这些机制,必将有助于DRIC的预警、预防及优化治疗。

     

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  • 收稿日期:  2018-12-12
  • 出版日期:  2019-02-20
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