FibroScan对肝细胞癌诊断价值的研究进展

李汨; 聂青和

doi:10.3969/j.issn.1001-5256.2015.06.035

FibroScan对肝细胞癌诊断价值的研究进展

DOI: 10.3969/j.issn.1001-5256.2015.06.035

李汨,
聂青和

第四军医大学唐都医院全军感染病诊疗中心

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2015-06-20

The progress of Fibro Scan technique for diagnosis of hepatocellular carcinoma value

Li Mi,
Nie QingHe

摘要

摘要: 肝细胞癌(HCC)是全球最常见的恶性肿瘤之一,其病因与肝硬化、慢性病毒性肝炎有关。瞬时弹性成像技术测量肝脏硬度可用来评估肝硬化患者发生HCC的风险。介绍了Fibro Scan的测量方法及其影响因素,归纳了Fibro Scan的临床应用,探讨了Fibro Scan对HCC的诊断价值、预测HCC预后的能力。提出Fibro Scan有助于诊断HCC,在将来可以减少HCC患者肝活组织检查的需要。
- 癌,肝细胞 /
- 弹性成像技术 /
- 诊断 /
- 综述
Abstract: Hepatocellular carcinoma( HCC) is one of the most common cancer worldwide,it considers that HCC arises in a background of cirrhosis or chronic infection with hepatitis virus. Liver stiffness assessed by transient elastography is described as a potential risk factor for HCC in cirrhosis. The technique and factors,clinical applications are presented. In addition,it discusses the diagnostic value of Fibro Scan and its performance for predicting the prognosis of HCC. It raises that Fibro Scan measurement is associated with risk of HCC,in the near future,the transient elastography method will decrease the need for liver biopsy in many patients with HCC.
- carcinoma hepatocellular /
- elasticity imaging techniques /
- diagnosis /
- review

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参考文献(34)

[1]WONG GL.Update of liver fibrosis and steatosis with transient elastography(Fibroscan)[J].Gastroenterol Rep(Oxf),2013,1(1):19-26.

[2]SANDRIN L,FOURQUET B,HASQUENOPH JM,et al.Transient elastography:a new noninvasive method for assessment of hepatic fibrosis[J].Ultrasound Med Biol,2003,29(12):1705-1713.

[3]SPOREA I,GILJA OH,BOTA S,et al.Liver elastography-an update[J].Med Ultrason,2013,15(4):304-314.

[4]MUELLER S,SANDRIN L.Liver stiffness:a novel parameter for the diagnosis of liver disease[J].Hepat Med,2010,2:49-67.

[5]BERZIGOTTI A,de GOTTARDI A,VUKOTIC R,et al.Effect of meal ingestion on liver stiffness in patients with cirrhosis and portal hypertension[J].PLo S One,2013,8(3):e58742.

[6]YOU SC,KIM KJ,KIM SU,et al.Factors associated with significant liver fibrosis assessed using transient elastography in general population[J].World J Gastroenterol,2015,21(4):1158-1166.

[7]VERMA S,JENSEN D,HART J,et al.Predictive value of ALT levels for non-alcoholic steatohepatitis(NASH)and advanced fibrosis in non-alcoholic fatty liver disease(NAFLD)[J].Liver Int,2013,33(9):1398-1405.

[8]COURNANE S,BROWNE JE,FAGAN AJ.The effects of fatty deposits on the accuracy of the Fibroscanliver transient elastography ultrasound system[J].Phys Med Biol,2012,57(12):3901-3914.

[9]YONEDA M,THOMAS E,SCLAIR SN,et al.Supersonic shear imaging and transient elastography with the XL probe accurately detect fibrosis in overweight or obese patients with chronic liver disease[J].Clin Gastroenterol Hepatol,2015.[Epub ahead of print]

[10]SEBASTIANI G,GHALI P,WONG P,et al.Physicians'practices for diagnosing liver fibrosis in chronic liver diseases:a nationwide,Canadian survey[J].Can J Gastroenterol Hepatol,2014,28(1):23-30.

[11]GOYAL R,MALLICK SR,MAHANTA M,et al.Fibroscan can avoid liver biopsy in Indian patients with chronic hepatitis B[J].J Gastroenterol Hepatol,2013,28(11):1738-1745.

[12]ZENG XH,SHI DR,WANG YM.New clinical progress in diagnosing liver disease using Fribro Scan[J].Chin J Pract Int Med,2014,34(12):1185-1188.(in Chinese)曾祥华,石代蓉,王宇明.Fibroscan用于慢性肝病临床诊治新进展[J].中国实用内科杂志,2014,34(12):1185-1188.

[13]CABIBI D,CALVARUSO V,GIUFFRIDA L,et al.Comparison of histochemical staining methods and correlation with transient elastography in acute hepatitis[J].Pathobiology,2015,82(1):48-52.

[14]KITSON MT,ROBERTS SK,COLMAN JC,et al.Liver stiffness and the prediction of clinically significant portal hypertension and portal hypertensive complications[J].Scand J Gastroenterol,2015,50(4):462-469.

[15]SPOREA I,RA爩IU I,BOTA S,et al.Are different cut-off values of liver stiffness assessed by transient elastography according to the etiology of livercirrhosis for predicting significant esophageal varices?[J].Med Ultrason,2013,15(2):111-115.

[16]HUA J,LIU GQ,BAO H,et al.The role of liver stiffness measurement in the evaluation of liver function and esophageal varices in cirrhotic patients[J].J Dig Dis,2015,16(2):98-103.

[17]FORNER A,LLOVET JM,BRUIX J.Hepatocellular carcinoma[J].Lancet,2012,379(9822):1245-1255.

[18]ABRALDES JG,ARAUJO IK,TURN F,et al.Diagnosing and monitoring cirrhosis:liver biopsy,hepatic venous pressure gradient and elastography[J].Gastroenterol Hepatol,2012,35(7):488-495.

[19]SINGH S,FUJII LL,MURAD MH,et al.Liver stiffness is associated with risk of decompensation,liver cancer,and death in patients with chronic liver diseases:a systematic review and meta-analysis[J].Clin Gastroenterol Hepatol,2013,11(12):1573-1584.

[20]PARK MS,HAN KH,KIM SU.Non-invasive prediction of development of hepatocellular carcinoma using transient elastography in patients with chronic liver disease[J].Expert Rev Gastroenterol Hepatol,2014,8(5):501-511.

[21]KUO YH,LU SN,HUNG CH,et al.Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis[J].Hepatol Int,2010,4(4):700-706.

[22]FEIER D,LUPSOR PLATON M,STEFANESCU H,et al.Transient elastography for the detection of hepatocellular carcinoma in viral C liver cirrhosis.Is there something else than increased liver stiffness?[J].J Gastrointestin Liver Dis,2013,22(3):283-289.

[23]FOUCHER J,CHANTELOUP E,VERGNIOL J,et al.Diagnosis of cirrhosis by transient elastography(Fibro Scan):a prospective study[J].Gut,2006,55(3):403-408.

[24]ANAPARTHY R,TALWALKAR JA,YIN M,et al.Liver stiffness measurement by magnetic resonance elastography is not associated with developing hepatocellular carcinoma in subjects with compensated cirrhosis[J].Aliment Pharmacol Ther,2011,34(1):83-91.

[25]EL-SERAG HB.Epidemiology of viral hepatitis and hepatocellular carcinoma[J].Gastroenterology,2012,142(6):1264-1273.

[26]WANG HM,HUNG CH,LU SN,et al.Liver stiffness measurement as an alternative to fibrotic stage in risk assessment of hepatocellular carcinoma incidence for chronic hepatitis C patients[J].Liver Int,2013,33(5):756-761.

[27]KIM MS,LEE JR.Assessment of liver stiffness measurement:novel intraoperative blood loss predictor?[J].World J Surg,2013,37(1):185-191.

[28]PESCE A,SCILLETTA R,BRANCA A,et al.Does transient elastography(Fibro Scan)have a role in decision making in hepatocellular carcinoma?[J].HPB(Oxford),2012,14(6):403-408.

[29]KIM SU,AHN SH,PARK JY,et al.Prediction of postoperative hepatic insufficiency by liver stiffness measurement(Fibro Scan)before curative resection of hepatocellular carcinoma:a pilot study[J].Hepatol Int,2008,2(4):471-477.

[30]CESCON M,COLECCHIA A,CUCCHETTI A,et al.Value of transient elastography measured with Fibro Scan in predicting the outcome of hepatic resection for hepatocellular carcinoma[J].Ann Surg,2012,256(5):706-712.

[31]BERZIGOTTI A,REIG M,ABRALDES JG,et al.Value of transient elastography measured with fibroscan in predicting the outcome of hepaticresection for hepatocellular carcinoma[J].Ann Surg,2015,261(4):e105.

[32]CRESPO G,LENS S,GAMBATO M,et al.Liver stiffness 1 year after transplantation predicts clinical outcomes in patients with recurrent hepatitis C[J].Am J Transplant,2014,14(2):375-383.

[33]BERENGUER M,ROCHE B,AGUILERA V,et al.Efficacy of the retreatment of hepatitis C virus infections after liver transplantation:role of an aggressive approach[J].Liver Transpl,2013,19(1):69-77.

[34]LEE SH,KIM SU,JANG JW,et al.Use of transient elastography to predict de novo recurrence after radiofrequency ablation for hepatocellular carcinoma[J].Onco Targets Ther,2015,2(8):347-356.

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