武山县苗丰村居民肝损害情况横断面调查分析

杨忠霞; 毛小荣; 袁宏

doi:10.3969/j.issn.1001-5256.2015.06.030

武山县苗丰村居民肝损害情况横断面调查分析

DOI: 10.3969/j.issn.1001-5256.2015.06.030

兰州大学第一医院感染科

基金项目:

2013年兰州大学自然科学类中央高校基本科研项目(lzujbky-2013-219)；

详细信息

中图分类号: R575
计量
- 文章访问数: 1790
- HTML全文浏览量: 21
- PDF下载量: 472
- 被引次数: 0
出版历程
- 出版日期: 2015-06-20

Investigation of impairment of liver function in local residents of Miaofeng Village,Wushan County,China

Research funding:

摘要

摘要:
目的调查甘肃省武山县马力镇苗丰村居民肝损害状况,分析居民肝损害的可能原因,为不明原因肝损害的病因研究提供依据。方法对苗丰村居民进行肝功能普查、流行病学调查;对肝功能异常者进行血清学检测;对居民饮用水及环境土壤行砷、铬、硒等微量元素的检测。结果苗丰村居民中血清ALT异常者占检测总数的23.8%,AST异常者占检测总数的10.7%;HBs Ag阳性11例,脂肪肝3例。土壤中微量元素硒缺乏。结论部分苗丰村居民存在肝损害。环境土壤微量元素硒缺乏可能是导致居民肝损害的原因之一。
- 肝功能不全 /
- 环境监测 /
- 甘肃
Abstract:
Objective To assess the impairment of liver function and investigate possible causes in local residents in Miaofeng Village,Mali Town,Wushan County,Gansu Province,China,and to provide a basis for the etiological study of idiopathic liver damage. Methods The residents in Miaofeng Village were screened for liver function and an epidemiological study was conducted. Serological testing was performed for those with abnormal screening results. Trace elements in drinking water and soil such as arsenic,chromium,and selenium were also tested. Results Of all residents,23. 8% and 10. 7% showed abnormal levels of alanine aminotransferase and aspartate aminotransferase,respectively. Positivity of HBs Ag was detected in 11 cases,fatty liver was identified in 3 cases,and absence of selenium in soil was also confirmed. Conclusion A proportion of local residents in Miaofeng Village have impaired liver function and the absence of selenium in soil may be a contributing factor to this phenomenon.
- hepoctic insufficiency /
- environmental monitoring /
- Gansu

HTML全文

参考文献(22)

[1] Ministry of Health of the People’s Republic of China,Standards for drinking water quality(G5749-20067).2006.(in Chinese)中华人民共和国卫生部.GB5749-2006生活饮用水卫生标准[S].2006.

[2]WEI FS,YANG GZ,JIANG DZ,et al.Basic statistics and features of background values of soil elements in China[J].Environl Monit China,1991,7(1):1-6.(in Chinese)魏复盛,杨国治,蒋德珍,等.中国土壤元素背景值基本统计量及其特征[J].中国环境监测,1991,7(1):1-6.

[3]FOUAD AA,AL-MULHIM AS,JRESAT I.Telmisartan treatment attenuates arsenic-induced hepatotoxicity in mice[J].Toxicology,2012,300(3):149-157.

[4]ZHANG Y,HUANG Y,DENG X,et al.Iron overload-induced rat liver injury:Involvement of protein tyrosine nitration and the effect of baicalin[J].Eur J Pharmacol,2012,680(1-3):95-101.

[5]MESSARAH M,KLIBET F,BOUMENDJEL A,et al.Hepatoprotective role and antioxidant capacity of selenium on arsenic-induced liver injury in rats[J].Exp Toxicol Pathol,2012,64(3):167-174.

[6]KRYUKOV GV,CASTELLANO S,NOVOSELOV SV,et al.Characterization of mammalian selenoproteomes[J].Science,2003,300(5624):1439-1443.

[7]LI XH,WANG YQ,CHENG WF,et al.Effect of different levels of dietary selenium on antioxidation and hepatic fibrosis in the rats[J].Chin J Dig,1999,19(5):309-311.(in Chinese)李宣海,汪余勤,程五凤,等.不同硒水平饲料对大鼠抗氧化和肝纤维化的影响[J].中华消化杂志,1999,19(5):309-311.

[8]RAYMAN MP.Selenium and human health[J].Lancet,2012,379(9822):1256-1268.

[9]CAO N,LIU YB,ZHAO HZ,et al.Relationship between selenium intake and hypertension of residents in rural areas of Jilin province[J].J Jilin Univ:Med Edit,2014,40(5):1109-1113.(in Chinese)曹宁,刘艳斌,赵惠子,等.吉林省农村地区居民硒摄入量与高血压的相关性[J].吉林大学报:医学版,2014,40(5):1109-1113.

[10]WINCZURA A,ZD Z·ALIK D,TUDEK B.Damage of DNA and proteins by major lipid peroxidation products in genome stability[J].Free Radic Res,2012,46(4):442-459.

[11]BRANCO V,GODINHO-SANTOS A,GONALVES J,et al.Mitochondrial thioredoxin reductase inhibition,selenium status,and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds[J].Free Radic Biol Med,2014,73:95-105.

[12]CHENG JZ,YANG P,GUI RY.Research progress on speciation of selenium compounds in plants[J].J Zhejiang A&F Univ,2012,29(2):288-295.(in Chinese)程建中,杨萍,桂仁意.植物硒形态分析的研究综述[J].浙江农林大学学报,2012,29(2):288-295.

[13]MENG HP,LI DY,YANG YZ.Research progress of the relationships between the immune function and the trace selenium element[J].Studies Trace Elements Health,2011,28(4):68-69.(in Chinese)孟惠平,李东影,杨延哲.机体免疫机能与微量元素硒关系的研究进展[J].微量元素与健康研究,2011,28(4):68-69.

[14]RAYMAN M.Selenium and cancer prevention[J].Hered Cancer Clin Pr,2012,10(Suppl 4):A1.

[15]PENNEY KL,LI H,MUCCI LA,et al.Selenoprotein P genetic variants and mrna expression,circulating selenium,and prostate cancer risk and survival[J].Prostate,2013,73(7):700-705.

[16]EPPLEIN M,BURK RF,CAI Q,et al.A prospective study of plasma selenoprotein P and lung cancer risk among low-income adults[J].Cancer Epidemiol Biomarkers Prev,2014,23(7):1238-1244.

[17]FRITZ H,KENNEDY D,FERGUSSON D,et al.Selenium and lung cancer:a systematic review and meta analysis[J].PLo S One,2011,6(11):e26259.

[18]ABOUL-SOUD MA,AL-OTHMAN AM,EL-DESOKY GE,et al.Hepatoprotective effects of vitamin E/selenium against malathion-induced injuries on the antioxidant status and apoptosis-related gene expression in rats[J].J Toxicol Sci,2011,36(3):285-296.

[19]FU KZ,GENG XX,LIAO HM,et al.Determination of hair selenium content in patients with chronic hepatitis:an analysis of 80 cases[J].Clin Focus(Med J),2005,20(14):822-823.(in Chinese)符孔舟,耿须霞,廖惠敏,等.80例慢性肝炎患者发硒含量检测分析[J].临床荟萃,2005,20(14):822-823.

[20]DUAN P,CHEN J,YANG B,et al.Effects of selenium against fluoride-induced oxidative stress and DNA damage of rat hepatocytes[J].China Public Health,2013,29(11):1626-1629.(in Chinese)段鹏,陈晋,杨波,等.硒拮抗氟致大鼠肝细胞氧化应激和DNA损伤作用[J].中国公共卫生,2013,29(11):1626-1629.

[21]TAN L,GUAN XQ,WANG Q.Experimental study about the effect of Vitamin E and sodium selenite on nonalcoholic fatty Iiver[J].J Chongqing Med Univ,2007,32(6):606-609,614.(in Chinese)谭丽,管小琴,王倩.维生素E、亚硒酸钠对非酒精性脂肪肝作用的实验研究[J].重庆医科大学学报,2007,32(6):606-609,614.

[22]ZHANG CY,ZHAO HP.Effect of selenium supply on anti-oxidative capacity in non-alcoholic steatohepatitis rats[J].J Shanxi Med Univ,2009,40(2):117-119.(in Chinese)张成琰,赵和平.补硒对非酒精性脂肪性肝炎大鼠肝脏抗氧化能力的影响[J].山西医科大学学报,2009,40(2):117-119.

施引文献

资源附件(0)

访问统计