Objective To analyze the usage of human serum albumin in patients with liver cancer and liver cirrhosis after hepatectomy.Methods A total of 121 patients with liver cancer and liver cirrhosis who received hepatectomy in our hospital from January 2012 to January2014 were divided into control group( n = 60) and observation group( n = 61). Both groups received human serum albumin in addition to the routine treatment for liver protection. The observation group was given intravenous drip of 5% human serum albumin within 48 h after surgery. The plasma albumin concentrations of patients were measured at 48 h after surgery,and if the concentration was < 35 g / L,the patients would be given 20% human serum albumin until the concentration was ≥35 g / L. The control group was given intravenous drip of 20%human serum albumin within 48 h after surgery until the plasma albumin concentration was ≥35 g / L. The amounts of used human serum albumin and plasma were recorded for both groups. The urine volume,abdominal drainage volume,central venous pressure( CVP),mean arterial pressure( MAP),and thromboelastogram( TEG) R and K values were measured at 1,3,7,and 10 days after surgery. The liver function indices before and after surgery and the indocyanine green retention rate at 15 minutes( ICG R15) at 7 days after surgery were measured. Comparison of continuous data between the two groups was made by t test,while comparison of categorical data was made by chisquare test. Results( 1) There were no significant differences in age,sex,Child- Pugh classification,surgical approach,intraoperative blood loss,occlusion time of the first porta hepatis,and operation time between the two groups( P > 0. 05). But there were significant differences in the amounts of used human serum albumin and plasma and the length of hospital stay between the two groups( P < 0. 05).( 2) There were significant differences in daily urine volume,CVP,MAP,abdominal drainage volume,and interstitial fluid volume at 1 and 3 days after surgery between the two groups( P < 0. 05),but there were no significant differences in the above indices at 7 days after surgery between the two groups( P > 0. 05). There were no significant differences in alanine aminotransferase,aspartate aminotransferase,total bilirubin,and TEG R and K values at 1 and 3 days after surgery between the two groups( P > 0. 05),but significant differences were observed in the above indices at 7 days after surgery( P < 0. 05).( 3) There was a significant difference in ICGR15 at 7 days after surgery between the observation group and the control group( 16. 59% ± 4. 4% vs 13. 21% ± 4. 2%,t = 5. 23,P = 0. 000). Conclusion The isotonic albumin and hypertonic albumin used in different periods after surgery have a better clinical effect than hypertonic albumin alone.