肝星状细胞、Toll样受体4信号途径、炎症及纤维化微环境与原发性肝癌发生发展的关系

吴玉婧; 郭津生

doi:10.3969/j.issn.1001-5256.2015.06.012

肝星状细胞、Toll样受体4信号途径、炎症及纤维化微环境与原发性肝癌发生发展的关系

DOI: 10.3969/j.issn.1001-5256.2015.06.012

复旦大学附属中山医院消化科

基金项目:

国家自然科学基金(81070340,91129705)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2015-06-20

Hepatic stellate cells,Toll-like receptor 4 signaling pathway,and inflammatory fibrotic microenvironment in the development of hepatocellular carcinoma

Research funding:

摘要

摘要: 肝细胞癌(HCC)的发生与炎症纤维化的癌前微环境密切相关。活化的肝星状细胞(HSC)是肝纤维化发生时基质的主要来源,也是肝脏炎症反应主要的效应细胞。HSC具有完整的Toll样受体(TLR)4信号途径,介导HSC的重要生物学特性,如纤维化发生、炎症表型和免疫调节功能。TLR4信号转导通路参与慢性肝脏疾病的发生和进展,介导肝纤维化和HCC的发生。HSC通过TLR4信号途径产生趋化因子和生长因子也被证实与癌症发生有关。
- 癌,肝细胞 /
- 肝硬化 /
- 炎症 /
- 细胞因子类 /
- Toll样受体4
Abstract: The development of hepatocellular carcinoma( HCC) is closely related to the precancerous microenvironment of inflammation and fibrosis. The activated hepatic stellate cells( HSCs) are the major source of extracellular matrix in the development of liver fibrosis and the key effective cells of hepatic inflammatory responses. HSCs have an intact Toll- like receptor 4( TLR4) signaling pathway,which mediates important biological properties of HSCs such as fibrogenesis,inflammatory phenotype,and immunoregulatory function. The TLR4 signaling pathway is involved in the development and progression of chronic liver diseases,and mediates liver fibrogenesis and HCC. HSCs produce several cytokines and growth factors by TLR4 signaling pathway,which has been confirmed to be related to the development of HCC.
- carcinoma,hepatocellular /
- liver cirrhosis /
- cytokines /
- inflammation /
- Toll-like receptor 4

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参考文献(30)

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