Abundant experience has been accumulated when it comes to the traditional Chinese medicine(TCM) prevention and treatment of chronic hepatitis B(CHB).However,there still exist some deficiencies such as insufficient randomized controlled trials(RCTs) and lack of attention to objective indices for therapeutic evaluation.Therefore,future clinical prevention and treatment should be tied closely to the research progress in the immune pathogenesis of CHB and give full play to the characteristics and advantages of TCM in modulating the functional status(including immunity) of human body.Moreover,clinical and translational research on the TCM regulation of immune response in CHB should be carried out to further improve clinical therapeutic effect.In addition,biochemistry,virology,and pathology should be applied actively in place of outcomes while paying attention to the symptoms of patients in an effort to improve the objectivity of therapeutic evaluation when summarizing clinical practice experience.Furthermore,RCTs should be employed as much as possible to enhance global recognition of the therapeutic effect of TCM treatment.And there is no doubt that bringing the advantages of integrated traditional Chinese and Western medicine therapy into full play will benefit a huge number of patients.