Recent perspectives on the role of microRNAs of the miR-15 family in liver disease

Ma LiXia; Wei XinHuan; Zhang Jing

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Feb. 2013

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Recent perspectives on the role of microRNAs of the miR-15 family in liver disease

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Published Date: 2013-02-20

Abstract

Abstract

Since their recent discovery, microRNAs (miRNAs) , a class of short endogenous non-coding RNAs, have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes.Under normal physiological conditions, the miR-15 family members regulate several important cellular functions, including apoptosis, cell differentiation, cell cycle, and stress responses.However, under pathological conditions, the miR-15 family members contribute to carcinogenesis, cardiovascular dysfunctions, and neurodegeneration;these activities may represent potentially useful targets of molecular therapeutic strategies.In this review, we summarize and discuss the important functions and promising therapeutic applications of the miR-15 family in liver cancer, acute liver failure, liver fibrosis, and liver damage.
- microRNAs,
- hepatitis,
- chronic,
- liver cirrhosis,
- liver failure

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References(30)

References

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Recent perspectives on the role of microRNAs of the miR-15 family in liver disease

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