Glypican-3 (GPC-3) signaling pathways contribute to the development and progression of hepatocellular carcinoma (HCC) .As a specific diagnostic marker of HCC, GPC-3 may also represent a novel therapeutic target.Recent studies have shown that molecular targeting of GPC-3 can significantly inhibit growth of HCC cells, as well as enhance apoptosis.Here, we discuss the underlying mechanisms of the GPC-3-mediated anti-proliferative and pro-apoptotic effects in HCC, which may help in development of improved GPC-3 targeted therapy.
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