The effects of CD34+ cell on the efficacy of autologous bone marrow stem cell transplantation in patients with cirrhosis

Shao XiaoDong; Guo XiaoZhong; Wang Di; Zou DeLi; Ren LiNan; Li HongYu; Zhao JiaJun

Issue 2

Feb. 2012

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Article Navigation > Journal of Clinical Hepatology > 2012 > 28(2): 127-129

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The effects of CD34+ cell on the efficacy of autologous bone marrow stem cell transplantation in patients with cirrhosis

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Published Date: 2012-02-20

Abstract

Abstract

Objective To investigate the effects of CD34+ cell on the efficacy of autologous bone marrow stem cell transplantation in patients with cirrhosis.Methods Forty one patients with cirrhosis treated with autologous bone marrow stem cell transplantation were analyzed retrospectively.There were 27 cases with CD34+ cell less than 5% and 14 cases with CD34+ more than 5% (including 5%) .The results of laboratory test of the patients during 2-4 weeks after the transplantation were collected and analyzed.Results After transplantation, the level of serum total protein, albumin, ALP and platelet of patients with CD34+ less than 5% was higher than that of pretransplantation (P<0.05) and the level of serum total protein and albumin of patients with CD34+ more than 5% was higher than that of pretransplantation (P<0.05) .Before transplantation, the platelet count of patients with CD34+ more than 5% (88.3 571±38.45 398×106/L) was lower than that of patients with CD34+ less than 5% (132.5 900±127.25 966×106/L) .Conclusion Autologous bone marrow stem cell transplantation could improve the level of serum total protein and albumin of patients with cirrhosis and CD34+ cell count didn't affect the improvement of serum total protein and albumin after transplantation.Autologous bone marrow stem cell transplantation may have effect on the bile drainage.Different degree of hypersplenia may be the reason of patients having different CD34+ cell count.
- CD34,
- bone marrow transplantation,
- stem cell transplantation,
- transplantation,
- autologous

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沈阳化工大学材料科学与工程学院沈阳 110142

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The effects of CD34+ cell on the efficacy of autologous bone marrow stem cell transplantation in patients with cirrhosis

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