Objective To study the serum cytokine level in patients with alcoholic liver cirrhosis. Methods The changes in serum cytokine level in compensated and decompensated alcoholic liver cirrhosis patients and healthy controls were measured by radioimmunoassay technique. Results The serum level of IL-6 increased and IL-10 decreased in compensated alcoholic cirrhosis patients whereas the levels of IL-6, TNF-α, IL-8 and TGF-β were increased in decompensated alcoholic liver cirrhosis patients.Conclusion The serum levels of IL-6, IL-8, TNF-α and TGF-β increased gradually with disease progress. Monitoring the serum cytokine levels change in compensated and decompensated alcoholic liver cirrhosis is helpful in disease prognosis.
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