肝动脉化疗栓塞联合内生场热疗治疗原发性肝癌的临床研究

Objective To investigate the efficacy and safety of TACE combined with hyperthermia with endogenetic field tumor hyperthermia system in treatment of primary hepatic carcinoma.Methods 46 patients with HPC were randomly divided into two groups.The observed group (23 patients) was treated with ADM, 5-FU, MMC and combined with hyperthermia.The control group (23patients) was treated with the same drugs except hyperthermia.Results The efficacy of the observed group and the control group were 69.6% and 39.1% respectively.There was significant difference between them (P<0.05) .The side effects were little and the main side effects included myelosuppression (Ⅰ-Ⅱ degree) , gastrointestinal reactions, and the side effects in the observed group was less than the control group.The average life span were 14 months and 8 months, the survival in 1 year were 65.2% and 34.8% respectively (P<0.05) .Conclusion The treatment of TACE combined with hyperthermia can enhance the therapy effect and survivval and reduce the side effect, it also was a safe and effective treatment.