慢性HBsAg携带者及非活动性HBV感染状态的病理学研究

Objective To observe the clinicopathological features of chronic HBsAg carriers diagnosed by clinicians and inactive HBV infectious states diagnosed by pathologists.Methods The clinicopathological and morphologic features (including HE staining, histology staining and immuno-histochemical staining) of 41 cases of chronic HBsAg carriers and 65 cases of inactive HBV infectious state were analyzed.Results Forty-one chronic HBsAg carriers presented no obvious abnormal symptoms, physical signs and liver function tests, But only 10 of them showed little morphologic changes, other 30 cases showing mild chronic hepatitis B, one inactive cirrhosis.Among 65 patients of inactive HBV infectious state with almost no inflammation and fibrosis in liver tissues only a few presented light abnormality of liver function tests.Conclusion Most chronic HBsAg carriers actually represented patients with mild chronic hepatitis B.The patients with inactive HBV infectious state only had mild abnormality of liver function.These two diagnoses are same meaning used differently by clinicians and pathologists.So the right diagnoses can be made only combining clinical and pathological information.