乙肝病毒携带者病毒基因型与肝组织病理变化的关系

Objective To study the relationship between HBV genotype and outcome of infected hepatitis B virus.Methods Serum samples from 139 asymptomatic HBsAg carriers (AsC) were collected and the HBV genotype were determined using of PCR microplate hybridization-ELISA technique, at the same time, all the liver biopsy were informed.Results Among 139 sera, 42 (30.2%) were genotype B, 97 (69.8%) were genotype C.Of 42 patients with genotype B, there were 5 patients with invisibly pathological lesions of hepatic tissue, 37 patients with chronic hepatitis B;Of 97 patients with genotype C, there were 2 patients with invisibly pathological lesions of hepatic tissue, 91 patients with chronic hepatitis B, 2 patients with liver cirrhosis.Conclusion The study shows that genotype C infection is associated with more advanced liver pathological lesion than genotype B for asymptomatic HBsAg carriers, Compared with genotype B, patients with genotype C infection tend to have a several damage of liver pathological lesions.