Changes of the level of TRECs in chronic hepatitis B patients before and after antiviral treatment

Ge GuoHong; Chen Ming; Li HongBing; Guo HaiYan; Wang LiPing

Issue 3

Mar. 2007

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Article Navigation > Journal of Clinical Hepatology > 2007 > 23(3): 163-165

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慢性乙型肝炎患者抗病毒治疗前后TRECs含量的变化

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Published Date: 2007-03-20

Abstract

Abstract

To quantitative analyze the T-cell receptor excision circles (TRECs) in chronic hepatitis B (CHB) patients before and after receiving interferon or adefovir dipivoxil.Quantitative detection of TRECs in peripheral blood mononuclear cells (PBMCs) from 27 normal individuals and 28 cases with CHB among which 15 cases treated with interferon and 13 cases with adefovir dipivoxil was performed by real-time fluorescence quantitative PCR.The mean value of TRECs in cases with CHB (7.29±2.26 copies/103 PBMCs) was lower than that in corresponding aged normal individuals (10.48±6.90 copies/103PBMCs) (P<0.05) .There was no statistical relationship between thymic output function and HBV DNA in CHB patients (r=0.06, P>0.05) .Interferon therapy increased the quantity of TRECs in CHB patients (12.77±5.25 vs 7.14±2.69 copies/103 PBMCs) (P<0.05) .There was no significant difference between the level of TRECs before and after adefovir dipivoxil treatment.The quantity of TRECs in CHB patients were lower than those in normal individuals.There was no significant relation between thymic output function and HBV DNA.The results indicated that interferon, but not adefovir dipivoxil, could increase the TRECs level in CHB patients.
- chronic hepatitis B,
- TCR rearrangement excision circles (TRECs) ,
- thymic output function,
- antiviral agent

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[1]Alatrakchi N, Koziel MJ.Antiviral T-cell responses and therapy inchronic hepatitis B[J].J Hepatol, 2003, 39 (4) ∶631-634.

[2]段学章, 王福生, 王敏, 等.抗病毒治疗对慢性乙型肝炎患者树突状细胞及淋巴细胞亚群的影响[J].中华传染病杂志, 2005, 23∶125-129.

[3] 龚非力.医学免疫学[M].北京:科学出版社, 2000∶4.

[4]Douek DC, McFarland RD, Keiser PH, et al.Changes in thymicfunction with age and during the treatment of HIV infection[J].Na-ture, 1998, 396 (6712) ∶690-695.

[5]李扬秋, 杨力建, 陈少华, 等.实时定量PCR检测正常人外周血T细胞和胸腺细胞中sjTRECs水平[J].现代临床医学生物工程学杂志, 2001, 7 (6) , 397-400.

[6]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8∶324-329.

[7]Al-Harthi L, Marchetti G, Steffens CM, et al.Detection of Tcellreceptor circles (TRECs) as biomarkers for de novo Tcell synthesisusing a quantitative polymerase chain reaction-enzyme linked immu-nosorbent assay (PCR-ELISA) [J].J Immunol Methods, 2000, 237 (1-2) ∶187-197.

[8]Aspinall R, Andrew D, Pido-Lopez J.Age-associated changes inthymopoiesis[J].Springer Semin Immunopathol, 2002, 24 (1) ∶87-101.

[9]Petridou E, Klimentopoulou AE, Moustaki M, et al.Recent thymicemigrants and prognosis in T-and B-cell childhood hematopoieticmalignancies[J].Int J Cancer, 2002, 101 (1) ∶74-77.

[10]Lewin SR, Heller G, Zhang L, et al.Direct evidence for newT-cell generation by patients after either T-cell-depleted or unmodi-fied allogeneic hematopoietic stem cell transplantations[J].Blood, 2002, 100 (6) ∶2235-2242.

[11]Cristiana DC, Franco P, Riccardo U, et al.Evluation of recent thy-mic emigrants (TRECS) in patients affected by HCVchronic hepatitis[J].Journal of Hepatology, 2002, 36 (Supplent 1) ∶222.

[12]Husa P.Adefovir dipivoxil-a new effective treatment for chronicinfection with hepatitis B virus[J].Klin Mikrobiol Infekc Lek, 2005, 11 (4) ∶119-122.

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慢性乙型肝炎患者抗病毒治疗前后TRECs含量的变化

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慢性乙型肝炎患者抗病毒治疗前后TRECs含量的变化

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