原发性肝癌C-kit和SCF基因的表达及意义

To explore the expressions and clinicopathological significance of C-kit and SCF in human hepatocellular carcinomas (HCCs) tissue.The expressions of C-kit and S CF were detected in 92 cases of HCCs by using SP immunohistochemical method, the corresponding paracancerous tissue and 30 cases of benign liver disease tissue w ere used to be control group.In the result, there were high and strong expressio ns of C-kit and SCF in HCCs low expressions in paracancerous tissue, no expressio n in benign liver disease tissue.There was marked difference (P<0.01) betw een the positive rate of HCCs and their paracancerous tissue?benign liver disea se tissue of C-kit and SCF.There was correlation between the expressions of C-ki t and SCF and abnormal AFP?the stage of HCCs?tumor emboli in the portal vein.T he overexpressions of C-kit and SCF protein may play a role in occurrence and pr ogression of HCCs.