HBsAg阴性的慢性乙型和丙型重叠感染肝炎患者临床研究

To study HBV-DNA levels and clinical features of HBsAg negative patients with chronic hepatitis Band C super-infection, sandwich hybidization on microplate assays were used to detect HBV quantification and HCV genotypes of 203 HBVM positive patients with chronic hepatitis C, and the clinical features of these patients were analyzed. Results showed that there was no difference between HBsAg negative and positive patients in the distribution of sex and ages, but the levels of ALT and TBil were higher in those HBsAg positive patients (P<0.05) . Infection rate of HCV Ⅱ/1b was higher in HBsAg negative patients (P<0.05) . Positive rates and the quantification of HBV-DNA in HBsAg negative patients were lower than those HBsAg positive patients. In HBsAg negative patients, positive rates of HBV-DNA in those only anti-HBc positive was the highest, but there was no difference in the quantification of HBV-DNA among them. Infection rate of HCV Ⅱ/1b was higher in HBV-DNA negative patients, it showed significant difference when compared with HBV-DNA positive patients.In conclusion, those patients with serious liver injury, anti-HBc positive or infected with HCV Ⅱ/1b, should be pay more attention, especially HCV-RNA negative with continuous liver injury, HBV-DNA shoule be detected in time even if HBsAg negative.