To investigate the effect of E-cadherin, MMP-2 and MMP-9 on invasion and metastasis of hepatocellular carcinoma (HCC) ; Surgical samples from 68 cases of HCC and their peritumorous tissues were detected by immunohistochemical technique In the group of high potential in vasion and mestastasis of HCC, the expressions of E-cadherin MMP-2 and MMP-9 were 9%, 42% and 61%, respectively, while in low potential group, they were 29%, 34% and 34%, respectively. There was a correlation between the expression of MMP-9 and the tumor invasion and metastasis in HCC ( P <0 05) and a reverse correlation between the expression of E-cadherin and the tumor invasion and metastasis potential in HCC ( P <0 05) . The expression of E-cadherin was significantly correlated with the differentiation of HCC. The positive rates in Edmondson's HCC Ⅳ grade were lower than that, in Ⅱ grade ( P <0 01) . The abnormal expressions of E-cadherin and MMP-9 were correlated with Edmondson's grade and the invasion and metastasis of HCC. E-cadherin MMP-2 and MMP-9 may be useful diagnostic parameters for the tumor invasion and metastasis in HCC.
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