A study on TTV DNA detection and clinical significance in patients with hepatitis of unknown etiology

Pan FaFen; Tao ZhiHua; Chen XiaoDong; Wang ZhongYong; Zhou ZuMu; Wu JianBo; Ding JianGuang; Chen YongPing; Wang ZhenLong

Issue 4

Apr. 2002

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Article Navigation > Journal of Clinical Hepatology > 2002 > 18(4): 228-229

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原因不明性肝炎血清中TTVDNA的检出及其临床意义

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Published Date: 2002-04-20

Abstract

Abstract

To investigate TTV infection among patients with hepatitis of unknown etiology and its clinical significance. A nested polymerase chain reaction (PCR) assay with primers from ORF1 of TTV genome was established to detect TTV DNA in 50 patients with hepatitis of unknown etiology, 40 health persons and 30 HBV carriers. The positive rate of TTV DNA in patients with hepatitis of unknown etiology, health persons and in HBV carriers were 32% (16/50) , 5% (2/40) and 6 7% (2/30) , respectively. It had statistical difference between them ( P <0 05) . Among 16 patients with TTV DNA positive response, 12 cases were chronic hepatitis (12/16, 75%) . TTV infection would be one of the major causes of hepatitis with unknown etiology in this areas.
- TT virus,
- Nested-PCR,
- Hepatitis with unknown etiology

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[1] 病毒性肝炎防治方案 (试行) 中华传染病杂志, 1995, 3∶241-247.

[2]OkamotoH , NishizawaT , KatoN , etal.MolecularcloningandcharacterizationofanovelDNAvirus (TTV) associatedwithpost transfusionhepatitisofunknownetiology[J].HepatologyResearch, 1998, 10∶1-15.

[3]周伯平, 马为明, 孙彤, 等TTV在非甲-庚型肝炎患者中的检测、克隆及测序[J].中华传染病杂志, 1998, 16∶131-133.

[4]罗朝霞, 郎振为, 阎慧平, 等地高辛素标记探针原位杂交法检测肝及肝外组织中的TTVDNA[J].中华医学杂志, 2000, 80∶438-439.

[5]黄呈辉, 陈汝光, 何忠平, 等PCR结合斑点杂交法检测血清TTVDNA[J].中华肝脏病杂志, 1999, 7∶110-111.

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原因不明性肝炎血清中TTVDNA的检出及其临床意义

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原因不明性肝炎血清中TTVDNA的检出及其临床意义

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