血清学非甲-戊型急性肝炎的病因分析

To investigate the etiology of nonA-E acute hepatitis in sera.65 liver tissues of patients with nonA-E acute hepatitis in serum were detected for hepatitis B, C, G, virus antigen and TTV DNA by immunohistochemistry (IHC) or in situ hybridization (ISH) , respectively.Of the 65 liver tissues, hepatitis B、C、G virus antigen and TTV DNA were detected in 34, 18, 32 and 20, respectively.Hepatitis B and G virus antigen were detected signifcantly more than hepatitis C virus antigen or TTV DNA (P<0.01or 0.05) .Difference of partial liver function, among acute simple B, G, TT and nonA-T viral hepatitis serohistologically decided, did not achieve statistical significance (P>0.05) .There were 7 cases (10.8%) with unknown etiology. Silent HBV, and HGV infection were the main cause of non A-E acute hepatitis. The pathogenisis of a proportion of the cases remain unexplained, supporting the hypothesis of the existance of an additional agent.