Study on fibrinogen bound sialic acid levels in the patients with liver cirrhosis

Zhou YuGui; Liu ChangYuan; Zhu ZhengGuan

Issue 1

Jan. 2000

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Article Navigation > Journal of Clinical Hepatology > 2000 > 16(1): 42-44

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肝硬化患者纤维蛋白原结合唾液酸水平的研究

Published Date: 2000-01-20

Abstract

Abstract

Fibrinogen was purified by precipitation from citrated plasma by saturated ammonium sulplvate.Fibrinogen bound sialic acid levels were determined in 26 patients with liver cirrhosis and 22 normal cotrols.The result of the patients with liver cirrhosis was (23.6±2.6) nmol/mg.The result of the controls was 18.4±3.7 nmol/mg.The level of the patients was significantly higher than that of the controls (P<0.01) .In addition there was relationship between prolongation of the thrombin time and fibrinogen bound sialic acid contents.Polymerization of fibrin monomer was inverse ratio with fibrinogen bound sialic acid.It suggests that fibrinogen boud sialic acid levels may be diagnostic index acquired dysfibrinogenaemia.

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[1]Okude.M ., yamanakaA , Morimotoyetal.SialicacidinFibrinogen :effectofSialicacidonfibrinegen fibrinconversionbythrombinandpropertiesofasialfibrinclot.Biol.pharm .Bull, 1993 , 16∶448

[][2 ]FrancisJ .L .SimmondsV .J ., IngramA .J ., etal.Theeffectofcar bontefrachloride inducedcirrhosisoftheliveronfibrinogen boundsidal icacidandsialytransferaseactivityintheratMed .Lab .Scie .1986, 43∶48

[][3 ]FrancisJL , ArmstrongDJ, Fibrinegen boundsidlicacidlevelsisthedysfibrinogenaemiaoflivediseaseHaemostasis.1982 , 11∶2 15

[4]黄志华 , 周玉贵 , 刘昌元等　纤维蛋白原结合唾液酸的测定及初步临床应用 , 临床检验杂志 , 1998年 , 16∶87

[5 ]口晶文　俊天性异常フイブリノグン血症记关する凝血学的研究　北海道医学杂志 , 1985 , 60∶748

[6]DangC .V ., shinC .K ., BellyW .R .etalFibrinogensialicacidresiduesarelowaffinitycalcium bindingsitesthatinfluencefibrinassem blyJBial.chem .1989, 64∶15 10 4

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肝硬化患者纤维蛋白原结合唾液酸水平的研究

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肝硬化患者纤维蛋白原结合唾液酸水平的研究

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