肝炎后肝硬化患者唾液酸水平的测定及在肝癌诊断中的意义

To evaluate the value of sialic acid in HCC diagnosis among patients with hepati tis involved liver cirrhosis (LC) .The sera were collected from 42 patients with HCC, 66 patients with liver cirrhosis accompanying chronic hepatitis, 24 patients with severe chronic hepatitis without liver cirrhosis, 12 patients with chronic o r subacute hepatic failure and 53 healthy people.Salic acid (SA) was detected by the method of chemical colorimetric analysis.AFP was detected by method of radi o immunoassay.When the cut-off value of SA is set at 590μg/ml, 15 of 42 HCC pati ents show SA positive, while no one of 43 LC patients and 45 healthy controls sho ws positive result.The sensitivity of SA in HCC diagnosis among LC patients was 35.7%.When combined AFP with SA, 33 among 41 HCC patients showed positive results , the sensitivity was 80.4% which was higher than that of AFP (68.29%) and SA (36. 59%) separately.SA has characteristics of tumor-specific and less interfered wit h liver inflammation.The level of SA is totally independent of that of AFP, w hich greatly enhanced HCC diagnostic value of AFP among patients with hepatitis involved liv er cirrhosis.