中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2016
Turn off MathJax
Article Contents

Value of spleen stiffness measured by noninvasive method in evaluating the severity of cirrhotic portal hypertension

DOI: 10.3969/j.issn.1001-5256.2016.08.041
  • Received Date: 2016-03-14
  • Published Date: 2016-08-20
  • Cirrhotic portal hypertension can lead to serious complications including esophageal variceal bleeding. Hepatic venous pressure gradient( HVPG) and upper gastrointestinal endoscopy can be used to evaluate the severity of portal hypertension and predict the risk of bleeding. However,both methods are invasive,which limits their clinical practice. Therefore,noninvasive techniques for the evaluation of portal hypertension will have certain advantages in clinical practice. This article introduces the noninvasive methods for the measurement of spleen stiffness,including transient elastography,acoustic radiation force impulse,real- time tissue elastography,and magnetic resonance elastography,as well as the value of these methods in evaluation of portal hypertension and influencing factors. It is pointed out that the difference in the diagnostic efficiency of spleen stiffness measured by these methods in portal hypertension needs to be verified by further studies.

     

  • loading
  • [1]RIZZO L,ATTANASIO M,PINZONE MR,et al.A new sampling method for spleen stiffness measurement based on quantitative acoustic radiation force impulse elastography for noninvasive assessment of esophageal varices in newly diagnosed HCV-related cirrhosis[J].Biomed Res Int,2014,2014:365982.
    [2]CASTERA L,PINZANI M,BOSCH J.Non invasive evaluation of portal hypertension using transient elastography[J].J Hepatol,2012,56(3):696-703.
    [3]de FRANCHIS R,BAVENO VI Faculty.Expanding consensus in portal hypertension:report of the Baveno VI Consensus Workshop:stratifying risk and individualizing care for portal hypertension[J].J Hepatol,2015,63(3):743-752.
    [4]THABUT D,MOREAU R,LEBREC D.Noninvasive assessment of portal hypertension in patients with cirrhosis[J].Hepatology,2011,53(2):683-694.
    [5] VIZZUTTI F,ARENA U,ROMANELLI RG,et al.Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis[J].Hepatology,2007,45(5):1290-1297.
    [6]COLECCHIA A,MONTRONE L,SCAIOLI E,et al.Measurement of spleen stiffness to evaluate portal hypertension and the presence of esophageal varices in patients with HCV-related cirrhosis[J].Gastroenterology,2012,143(3):646-654.
    [7] YE XP,RAN HT,CHANG J,et al.Liver and spleen stiffness measured by acoustic radiation force impulse elastography for noninvasive assessment of liver fibrosis and esophageal varices in patients with chronic hepatitis B[J].J Ultrasound Med,2012,31(8):1245-1253.
    [8] HU X,XU X,ZHANG Q,et al.Indirect prediction of liver fibrosis by quantitative measurement of spleen stiffness using the FibroS can system[J].J Ultrasound Med,2014,33(1):73-81.
    [9] CALVARUSO V,BRONTE F,CONTE E,et al.Modified spleen stiffness measurement by transient elastography is associated with presence of large oesophageal varices in patients with compensated hepatitis C virus cirrhosis[J].J Viral Hepat,2013,20(12):867-874.
    [10] SHARMA P,KIRNAKE V,TYAGI P,et al.Spleen stiffness in patients with cirrhosis in predicting esophageal varices[J].Am JGastroenterol,2013,108(7):1101-1107.·
    [11] ZYKUS R,JONAITIS L,PETRENKIEN EV,et al.Liver and spleen transient elastography predicts portal hypertension in patients with chronic liver disease:a prospective cohort study[J].BMCGastroenterol,2015,15(1):183.
    [12] FRAQUELLI M,GIUNTA M,POZZI R,et al.Feasibility and reproducibility of spleen transient elastography and its role in combination with liver transient elastography for predicting the severity of chronic viral hepatitis[J].J Viral Hepat,2014,21(2):90-98.
    [13]TAPPER EB,COHEN EB,PATEL K,et al.Levels of alanine aminotransferase confound use of transient elastography to diagnose fibrosis in patients with chronic hepatitis C virus infection[J].Clin Gastroenterol Hepatol,2012,10(8):932-937.
    [14] TRIFAN A,SFARTI C,COJOCARIU C,et al.Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis[J].Hepat Mon,2011,11(5):372-375.
    [15] KIM SU,KIM JK,PARK YN,et al.Discordance between liver biopsy and Fibroscanin assessing liver fibrosis in chronic hepatitis B:risk factors and influence of necroinflammation[J].PLoS One,2012,7(2):e32233.
    [16] WAHL K,ROSENBERG W,VASKE B,et al.Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis(ELF)score compared to transient elastography[J].PLoS One,2012,7(12):e51906.
    [17]ARENA U,LUPSOR PLATON M,STASI C,et al.Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution[J].Hepatology,2013,58(1):65-72.
    [18]NIGHTINGALE K,SOO MS,NIGHTINGALE R,et al.Acoustic radiation force impulse imaging:in vivo demonstration of clinical feasibility[J].Ultrasound Med Biol,2002,28(2):227-235.
    [19]TAKUMA Y,NOUSO K,MORIMOTO Y,et al.Measurement of spleen stiffness by acoustic radiation force impulse imaging identifies cirrhotic patients with esophageal varices[J].Gastroenterology,2013,144(1):92-101.
    [20] PARK J,KWON H,CHO J,et al.Is the spleen stiffness value acquired using acoustic radiation force impulse(ARFI)technology predictive of the presence of esophageal varices in patients with cirrhosis of various etiologies?[J].Med Ultrason,2016,18(1):11-17.
    [21] TAKUMA Y,NOUSO K,MORIMOTO Y,et al.Portal hypertension in patients with liver cirrhosis:diagnostic ccuracy of spleen stiffness[J].Radiology,2016,279(2):609-619.
    [22]RIFAI K,CORNBERG J,BAHR M,et al.ARFI elastography of the spleen is inferior to liver elastography for the detection of portal hypertension[J].Ultraschall Med,2011,32(2):e24-e30.
    [23] FRIEDRICH-RUST M,NIERHOFF J,LUPSOR M,et al.Performance of acoustic radiation force impulse imaging for the staging of liver fibrosis:a pooled meta-analysis[J].J Viral Hepat,2012,19(2):e212-219.
    [24] GHEORGHE L,IACOB S,GHEORGHE C,et al.Real-time sonoelastography-a new application in the field of liver disease[J].J Gastrointestin Liver Dis,2008,17(4):469-474.
    [25] HIROOKA M,OCHI H,KOIZUMI Y,et al.Splenic elasticity measured with real-time tissue elastography is a marker of portal hypertension[J].Radiology,2011,261(3):960-968.
    [26]OCHI H,HIROOKA M,KOIZUMI Y,et al.Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases[J].Hepatology,2012,56(4):1271-1278.
    [27]MANDUCA A,OLIPHANT TE,DRESNER MA,et al.Magnetic resonance elastography:non-invasive mapping of tissue elasticity[J].Med Image Anal,2001,5(4):237-254.
    [28] GUO J,HIRSCH S,STREITBERGER KJ,et al.Patient-activated three-dimensional multifrequency magnetic resonance elastography for high-resolution mechanical imaging of the liver and spleen[J].Rofo,2014,186(3):260-266.
    [29] TALWALKAR JA,YIN M,VENKATESH S,et al.Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension[J].AJR Am J Roentgenol,2009,193(1):122-127.
    [30] MANNELLI L,GODFREY E,JOUBERT I,et al.MR elastography:spleen stiffness measurements in healthy volunteers-preliminary experience[J].AJR Am J Roentgenol,2010,195(2):387-392.
    [31] DYVORNE HA,JAJAMOVICH GH,BESA C,et al.Simultaneous measurement of hepatic and splenic stiffness using MR elastography:preliminary experience[J].Abdom Imaging,2015,40(4):803-809.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2383) PDF downloads(406) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return