2016 No. 8

Abstract:
Hepatitis B virus( HBV) tends to mutate easily due to its special structure and life cycle. Mutation changes the biological behavior of HBV and its sensitivity to antiviral drugs and even affects therapeutic effect and accelerate disease progression. The point mutations are commonly see in the pre- ...

Alternative methods for diagnosis of esophageal varices in patients with liver cirrhosis

Deng Han, Qi XingShun, Zhu Qiang, Guo XiaoZhong

2016, 32(8): 1468-1473. DOI: 10.3969/j.issn.1001-5256.2016.08.007

Abstract(2610)

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Abstract:
Esophageal variceal bleeding is one of the most serious complications of liver cirrhosis. Upper gastrointestinal endoscopy( UGE)is the gold standard for the diagnosis of esophageal varices,but it is invasive. Recently,several studies have reported some alternative methods for the diagnosis of esopha...

Reconsideration of the clinical value of anatomical hepatectomy in surgical resection of liver cancer

Zhang YaMin

2016, 32(8): 1474-1476. DOI: 10.3969/j.issn.1001-5256.2016.08.008

Abstract(2412)

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Abstract:
The surgical resection of liver cancer consists of anatomical and non- anatomical resection,and controversy still exists over the application of these two procedures in clinical practice. This article introduces the technical points of anatomical and non- anatomical hepatectomy and analyzes the effe...

Research advances in radiological examination for nonalcoholic fatty liver disease

Ye JunZhao, Zhong BiHui

2016, 32(8): 1477-1482. DOI: 10.3969/j.issn.1001-5256.2016.08.009

Abstract(2377)

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Abstract:
There is a high prevalence of nonalcoholic fatty liver disease( NAFLD) around the world,and early diagnosis and evaluation of liver fatty degeneration and fibrosis degree play important roles in the early treatment and prognostic evaluation of patients with NAFLD. This article reviews the principles...

Several issues regarding evaluation of renal injury and renal insufficiency in patients with liver disease

Hao KunYan, Yu YueCheng

2016, 32(8): 1483-1487. DOI: 10.3969/j.issn.1001-5256.2016.08.010

Abstract(2529)

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Abstract:

In patients with liver disease such as viral hepatitis and liver cirrhosis,renal injury and renal insufficiency can be generally classified as acute kidney injury( AKI),chronic kidney disease,and acute- on- chronic nephropathy. AKI can be classified as stage 1( risk stage),stage 2( injury stage),and...

Biochemical parameters in diagnosis of cholestatic liver disease

Sun FengXia, Sui JingLi, Li Pan, Wang Man, Wu Fang, Li XiaoLing

2016, 32(8): 1488-1490. DOI: 10.3969/j.issn.1001-5256.2016.08.011

Abstract(2661)

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Abstract:
Although guidelines and expert consensuses have been published on the diagnosis and treatment of cholestatic liver disease recently in China and the rest of the world,many problems still exist in the biochemical standard for the diagnosis of cholestasis; for example,there are substantially different...

Research advances in treatment of primary biliary cholangitis

Li YanMei, Wang QiXia, Ma Xiong

2016, 32(8): 1491-1496. DOI: 10.3969/j.issn.1001-5256.2016.08.012

Abstract(2665)

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Abstract:
Primary biliary cholangitis( PBC) is an autoimmune liver disease mainly involving intrahepatic interlobular bile ducts and can progress to liver fibrosis,cirrhosis,and even liver failure. At present,the only drug approved for the treatment of PBC is ursodeoxycholic acid( UDCA),but up to 40% of PBC p...

Original articles_Viral hepatitis

Effect of protein acetylation on hepatitis B virus replication

Jia XiaoFang, Zhang XiaoNan, Wu Ao, Zhang LiJun, Yuan ZhengHong

2016, 32(8): 1497-1501. DOI: 10.3969/j.issn.1001-5256.2016.08.013

Abstract(1848)

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Abstract:

Objective To investigate the effect of protein acetylation in host cells on the replication of hepatitis B virus( HBV) in hepatocytes,since HBV infection greatly threatens human health and the acetylation of encoding proteins in infected cells plays an important role in HBV replication and infection...

Original articles_Liver fibrosis and liver cirrhosis

Clinical effect of Dahuang Zhechong capsules combined with entecavir in treatment of chronic hepatitis B patients with liver fibrosis

Xie YongCai, Hu GuoXin, Peng YanZhong, Zheng Jie, Li YinPing

2016, 32(8): 1502-1507. DOI: 10.3969/j.issn.1001-5256.2016.08.014

Abstract(2224)

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Abstract:

Objective To investigate the clinical effect of Dahuang Zhechong capsules combined with entecavir in the treatment of chronic hepatitis B( CHB) patients with liver fibrosis. Methods A total of 100 CHB patients with liver fibrosis who visited or were hospitalized in Shenzhen Hospital of Peking Univer...

The predictive values of three noninvasive indices in diagnosis of liver fibrosis in patients with chronic hepatitis B: a comparative study

Zhuang XiaoFang, Ma Yan, Wang XiaoZhong, Wang Yan, Guo Feng, Wang XiaoBo

2016, 32(8): 1508-1512. DOI: 10.3969/j.issn.1001-5256.2016.08.015

Abstract(2693)

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Abstract:
Objective To investigate the values of Fibro Touch,FIB- 4 index,and aspartate aminotransferase- to- platelet ratio index( APRI) in the diagnosis of liver fibrosis in patients with chronic hepatitis B( CHB). Methods A total of 148 patients with CHB who visited Traditional Chinese Medicine Hospital of...

Fibro Scan in diagnosis of liver fibrosis in patients with different chronic liver diseases: a comparative analysis

Lu HaiYing, Liu LingFeng, Xu XiaoYuan, Yu YanYan, Wu ChiHong

2016, 32(8): 1513-1517. DOI: 10.3969/j.issn.1001-5256.2016.08.016

Abstract(2411)

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Abstract:
Objective To investigate the similarities and differences of Fibro Scan in the diagnosis of liver fibrosis in patients with different chronic liver diseases. Methods The clinical data of 516 patients with chronic liver diseases who visited Peking University First Hospital from October 2012 to Januar...

Efficacy of Jiawei Jianpi Bushen prescription in treatment of liver fibrosis and its role in regulating Treg/Th17 balance

Pan Kai, Zhao Qiang, Tao YanYan, Chen GaoFeng, Liu ChengHai

2016, 32(8): 1518-1524. DOI: 10.3969/j.issn.1001-5256.2016.08.017

Abstract(340)

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Abstract:
Objective To investigate the therapeutic effect of Jiawei Jianpi Bushen prescription in liver fibrosis in rats and its effect on regulatory T( Treg) cells and T helper 17( Th17) cells. Methods A total of 32 male Wistar rats were randomly divided into normal group,model group,Jianpi Bushen prescripti...

Clinical efficacy of entecavir in HBeAg-negative chronic hepatitis B with compensated cirrhosis

Han BenLi

2016, 32(8): 1525-1528. DOI: 10.3969/j.issn.1001-5256.2016.08.018

Abstract(2473)

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Abstract:
Objective To investigate the clinical efficacy of 96- week entecavir( ETV) treatment for HBe Ag- negative chronic hepatitis B patients with compensated cirrhosis,as well as its effect on patients with different HBV DNA loads. Methods A total of 118 chronic hepatitis B patients with compensated cirrh...

Long-term therapeutic effect of transjugular intrahepatic portosystemic shunt in patients with intractable cirrhotic ascites and prognostic factors

Ju Wei, Zhang BoJing, Han GuoHong

2016, 32(8): 1529-1533. DOI: 10.3969/j.issn.1001-5256.2016.08.019

Abstract(2446)

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Abstract:
Objective To investigate the long- term therapeutic effect of transjugular intrahepatic portosystemic shunt( TIPS) in patients with intractable cirrhotic ascites and prognostic factors. Methods A retrospective analysis was performed for the clinical data of 57 patients with intractable cirrhotic asc...

Significance of serum ischemia-modified albumin level in evaluating liver function in patients with liver cirrhosis of various causes

Chen ChengLiang, Song Wei, Meng XiuNa, Tian Xing, Jiao Jian

2016, 32(8): 1534-1537. DOI: 10.3969/j.issn.1001-5256.2016.08.020

Abstract(2330)

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Abstract:
Objective To investigate the differences in serum levels of ischemia- modified albumin( IMA) and IMA / albumin ratio( IMAR) in patients with liver cirrhosis of various causes,as well as the significance of IMA measurement and IMAR in evaluating liver function. Methods A total of 456 patients with li...

Original articles_Liver neoplasms

Epidemiological and clinical features of primary liver cancer: an analysis of 236 patients

Zhao RongRong, Deng YongDong, Yuan Hong

2016, 32(8): 1538-1542. DOI: 10.3969/j.issn.1001-5256.2016.08.021

Abstract(2463)

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Abstract:
Objective To investigate the epidemiological and clinical features of patients with primary liver cancer( PLC). Methods A retrospective analysis was performed for the clinical data of 236 patients with complete information who were admitted to The First Hospital of Lanzhou University and diagnosed w...

Synergistic effect of interventing insulin-like growth factor-Ⅰ receptor activation combined with anti-cancer drugs in inhibiting the proliferation of hepatocellular carcinoma cells

Cai Yin, Yao Min, Wang Li, Dong ZhiZhen, Gu JuanJuan, Yan XiaoDi, Qiu LiWei, Yao DengFu

2016, 32(8): 1543-1548. DOI: 10.3969/j.issn.1001-5256.2016.08.022

Abstract(420)

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Abstract:
Objective To investigate the intervention of gene transcription of insulin- like growth factor- Ⅰ receptor( IGF- ⅠR) and its synergistic effect with anti- cancer drugs in inhibiting the proliferation of hepatocellular carcinoma( HCC) cells. Methods The HBV-positive HCC PLC / PRF /5 and HBV- negative...

Expression and clinical significance of astrocyte elevated gene-1,β-catenin,and cyclin D1 in hepatocellular carcinoma

Yu Ying, Luo XinHua, Cheng MingLiang, Cheng YunJuan

2016, 32(8): 1549-1552. DOI: 10.3969/j.issn.1001-5256.2016.08.023

Abstract(389)

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Abstract:
Objective To investigate the expression and clinical significance of astrocyte elevated gene- 1( AEG- 1),β- catenin,and cyclin D1 in hepatocellular carcinoma( HCC) tissues. Methods A total of 40 HCC samples and 40 samples of corresponding para- carcinoma tissues from the patients with pathologically...

Original articles_Biliary diseases

Predictive value of serum CA19-9 in predicting acute cholangitis in patients with obstructive jaundice

Pan YaJun, Sun ShaoFu

2016, 32(8): 1553-1556. DOI: 10.3969/j.issn.1001-5256.2016.08.024

Abstract(1673)

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Abstract:
Objective To investigate the predictive factors for acute cholangitis in patients with obstructive jaundice. Methods A retrospective analysis was performed for the clinical data of 358 patients with common bile duct stones and obstructive jaundice who were treated in The Fourth People's Hospital of ...

Original articles_Others

Clinical efficacy of Qinggan Huashi Huoxue decoction combined with liver-protecting and enzyme-lowering drugs in treatment of alcoholic liver disease

Yao ZhiShan, Liu DingDing, Yun Xiang

2016, 32(8): 1557-1561. DOI: 10.3969/j.issn.1001-5256.2016.08.025

Abstract(2525)

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Abstract:

Objective To investigate the clinical efficacy and safety of Qinggan Huashi Huoxue decoction combined with liver- protecting and enzyme- lowering drugs in the treatment of alcoholic liver disease( ALD). Methods A total of 175 ALD patients who were admitted to The Second People's Hospital of Tangshan...

Application of drug lymphocyte stimulation test using cell counting kit-8 assay in diagnosis of acute drug-induced liver injury

Fan ZuoPeng, Liang Shan, Nie Wei, Chou LiXia, Chen Jie, Zhang Jing, Jin RongHua, Hu ZhongJie

2016, 32(8): 1562-1565. DOI: 10.3969/j.issn.1001-5256.2016.08.026

Abstract(2523)

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Abstract:

Objective To develop a novel drug lymphocyte stimulation test( DLST) using cell counting kit- 8( CCK- 8) assay,and to investigate its application in the diagnosis of acute drug- induced liver injury( DILI). Methods The patients with acute DILI who were admitted to Beijing You An Hospital from Januar...

Hepatocyte autophagy model established by physical method

Zhu XueMin, Meng QingHua

2016, 32(8): 1566-1570. DOI: 10.3969/j.issn.1001-5256.2016.08.027

Abstract(2503)

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Abstract:

Objective To establish the autophagy model of normal human liver cell line 7702 induced by hypoxia and starvation,and to lay a foundation for further studies on the influence of autophagy on liver function. Methods The 7702 cells were selected and incubated with95% air and 5% CO2 at a temperature of...

Characteristics of gene mutation in Chinese patients with hereditary hemochromatosis

Lu: TingXia, Zhang Wei, Li XiaoJin, Xu AnJian, Zhao XinYan, Ou XiaoJuan, Huang Jian

2016, 32(8): 1571-1574. DOI: 10.3969/j.issn.1001-5256.2016.08.028

Abstract(3231)

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Abstract:

Objective To investigate the characteristics of gene mutation in Chinese patients with hereditary hemochromatosis( HH).Methods A total of 9 patients with HH who visited Beijing Friendship Hospital,Capital Medical University from January 2013 to December2015 were enrolled. The genomic DNA was extract...

Brief reports

Neuroendocrine neoplasm of the bile duct: a clinical analysis of 5 cases

Gao Yan, Lin ShuCui, Wang YiQian, Zhang TianHao, Li WenChao, Cao JingYu

2016, 32(8): 1575-1577. DOI: 10.3969/j.issn.1001-5256.2016.08.029

Abstract(1815)

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Abstract:

Case reports

Clinical cure of chronic hepatitis B: a case report

Zhang ZeTian, Ji HuiFan, Chen Shuai, Li Xu, Yang WenXuan, Zhang GuoShan, Guo XiaoLin

2016, 32(8): 1578-1579. DOI: 10.3969/j.issn.1001-5256.2016.08.030

Abstract(1959)

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Abstract:

A case of acute coinfection with HBV and HCV

Dong Bing, Zhang PingPing, Zhao PeiDong, Jin YongSheng, Xu GuangHua

2016, 32(8): 1580-1581. DOI: 10.3969/j.issn.1001-5256.2016.08.031

Abstract(1499)

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Abstract:

Liver failure due to chronic hepatitis C with hyperthyroidism: a case report

Wang Wei, Lu WeiNa, Yao ChunFu, Shao ShiXiang, Gao HengBo

2016, 32(8): 1582-1583. DOI: 10.3969/j.issn.1001-5256.2016.08.032

Abstract(1584)

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Abstract:

Hepatic cirrhosis with Wernicke encephalopathy: a case report

He LiLi, Ning XiuJing, Guo XiaoLin, Ji HuiFan

2016, 32(8): 1584-1585. DOI: 10.3969/j.issn.1001-5256.2016.08.033

Abstract(1720)

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Abstract:

A case of primary hepatic carcinoid tumor

Fan WenHai, Zhao ZhengBin, Wang FeiFei, Chen QingFeng

2016, 32(8): 1586-1587. DOI: 10.3969/j.issn.1001-5256.2016.08.034

Abstract(1977)

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Abstract:

One case of primary amyloidosis

Yao Wei, Mi ShaoPing, Wang XiaoDong, Wang EnCheng, Liu JuRong, Li Bo, Wang Jing

2016, 32(8): 1588-1589. DOI: 10.3969/j.issn.1001-5256.2016.08.035

Abstract(2127)

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Abstract:

Successful treatment of adult-onset Still' s disease complicated by acute severe hepatic lesion and hemophagocytic syndrome: a case report

Xu Fang, Hou Jie, Zhang Yu, Qin JunJie

2016, 32(8): 1590-1591. DOI: 10.3969/j.issn.1001-5256.2016.08.036

Abstract(2432)

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Abstract:

Langerhans cell histiocytosis with hepatic lesion as the first symptom in children: a case report and literature review

Ou YangWenXian, Tang Lian, Cao Min, Chen WeiJian, Jiang Tao, Kang Zhen, Li ShuangJie

2016, 32(8): 1592-1595. DOI: 10.3969/j.issn.1001-5256.2016.08.037

Abstract(2158)

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Abstract:

Portal hypertension as the main clinical manifestations of myelofibrosis with acute cholecystitis: a case report

Li Xu, Guo XiaoLin, Ji HuiFan, Gao PuJun

2016, 32(8): 1596-1597. DOI: 10.3969/j.issn.1001-5256.2016.08.038

Abstract(2091)

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Abstract:

A case of clear cell renal cell carcinoma with pancreatic metastases

Ma YuTeng, Chen YuGuo, Liu ShuHan, Zhou JianPeng, Wang GuangYi, Wei Feng

2016, 32(8): 1598-1599. DOI: 10.3969/j.issn.1001-5256.2016.08.039

Abstract(2350)

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Abstract:

Reviews

Regulatory effect of interleukin-10 on natural killer cells in patients with chronic hepatitis B

Zhou Liang, Li XiaoYan, Huang YueHua

2016, 32(8): 1600-1603. DOI: 10.3969/j.issn.1001-5256.2016.08.040

Abstract(2168)

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Abstract:
At present,it is very difficult to cure chronic hepatitis B( CHB) with current therapeutic methods. Natural killer( NK) cells are an important part of innate immunity and play an important role in immune surveillance and early anti- infectious immune process. Interleukin- 10( IL- 10) is a multifunct...

Value of spleen stiffness measured by noninvasive method in evaluating the severity of cirrhotic portal hypertension

Wu LingZhi, Cui XiangHua, Jia JiDong

2016, 32(8): 1604-1607. DOI: 10.3969/j.issn.1001-5256.2016.08.041

Abstract(2439)

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Abstract:
Cirrhotic portal hypertension can lead to serious complications including esophageal variceal bleeding. Hepatic venous pressure gradient( HVPG) and upper gastrointestinal endoscopy can be used to evaluate the severity of portal hypertension and predict the risk of bleeding. However,both methods are ...

Research advances in liver cirrhosis complicated by portal vein thrombosis

Kang FuLai, Zhang YueXin

2016, 32(8): 1608-1612. DOI: 10.3969/j.issn.1001-5256.2016.08.042

Abstract(2316)

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Abstract:
Portal vein thrombosis( PVT) is a common complication in patients with liver cirrhosis. The development of PVT in patients with liver cirrhosis has not been taken seriously emphasis by clinicians,and there are few related studies. Up to now,no consensus has been reached on the diagnosis and treatmen...

Formation of collateral circulation in patients with cirrhotic portal hypertension and its clinical significance

Tang ShanHong, Zeng WeiZheng, Wu XiaoLing, Ren Juan, Lin Wei, Jiang MingDe

2016, 32(8): 1613-1616. DOI: 10.3969/j.issn.1001-5256.2016.08.043

Abstract(3552)

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Abstract:

Portal hypertension is a common clinical disease and brings a series of complications including the formation of gastrointestinal varicose veins,ascites,hepatic encephalopathy,and abdominal varicose veins. Most of these complications are related to the opening of collateral circulation after the inc...

Role of vitamin D and vitamin D receptor in evaluation and treatment of liver cirrhosis

Zhu BingHua, Xu LieMing

2016, 32(8): 1617-1621. DOI: 10.3969/j.issn.1001-5256.2016.08.044

Abstract(413)

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Abstract:
Vitamin D is mainly produced in the liver,and chronic liver injury caused by various reasons will affect the metabolism of vitamin D,lead to vitamin D deficiency,and accelerate disease progression. Recent studies have confirmed that in patients with liver cirrhosis,the degree of vitamin D deficiency...

Role of intestinal flora in the development and progression of spontaneous bacterial peritonitis

Luan YuTing, Cai WenJun, Xu Ying, Liu Ping, Mu YongPing

2016, 32(8): 1622-1625. DOI: 10.3969/j.issn.1001-5256.2016.08.045

Abstract(1980)

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Abstract:
Spontaneous bacterial peritonitis( SBP) is a major complication of liver cirrhosis. In recent years,with the development of biotechnology,such as high- throughput sequencing and intestinal metagenomics,the role of intestinal flora in liver diseases has been taken more and more seriously. Bacterial t...

Role of T-helper cell 17 in the development and progression of hepatocellular carcinoma

Zhang FeiFei, Chen Hui, Lyu Jun

2016, 32(8): 1626-1629. DOI: 10.3969/j.issn.1001-5256.2016.08.046

Abstract(1454)

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Abstract:

Hepatocellular carcinoma( HCC) is one of the most common malignant tumors in the world. How to improve cure rate and reduce recurrence and metastasis of HCC have always been hot topics in research. T- helper cell 17( Th17),an important subset of CD4+T-helper cells,plays a critical role in infection,...

Expression of programmed death-ligand 1 in hepatocellular carcinoma and its clinical significance

Yang Liu, Zhu XiLing, Li Gong

2016, 32(8): 1630-1634. DOI: 10.3969/j.issn.1001-5256.2016.08.047

Abstract(2150)

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Abstract:
In recent years,the immunotherapy based on the blocking of programmed death- 1( PD- 1) / programmed death- ligand 1( PD- L1)pathway has achieved encouraging progress in the treatment of malignant tumors such as melanoma and lung cancer. More and more studies have focused on its role in hepatocellula...