Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus

Yarong SONG; Jie WANG; Jie LI

doi:10.12449/JCH241107

Volume 40 Issue 11

Nov. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(11): 2168-2172

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Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus

DOI: 10.12449/JCH241107

Yarong SONG,
Jie WANG^{,
,},
Jie LI^{,
,}

Department of Microbiology & Infectious Disease Center，School of Basic Medical Sciences，Peking University Health Science Center，Beijing 100191，China

Research funding:

National Key Research and Development Program of China (2023YFC2306902);

National Natural Science Foundation of China (82172251)

More Information

Corresponding author: WANG Jie， wangjie2015@hsc.pku.edu.cn （ORCID： 0000-0001-6518-948X）; LI Jie， jieli@hsc.pku.edu.cn （ORCID： 0000-0001-7864-0460）
Received Date: 2024-08-28
Accepted Date: 2024-09-30
Published Date: 2024-11-25

Abstract

Abstract

Chronic hepatitis B virus （HBV） infection is a major global public health threat. In areas with moderate to high prevalence of HBV， mother-to-child transmission （MTCT） remains the main source of chronic HBV infection. With the application of combined immunization of hepatitis B vaccine and hepatitis B immunoglobulin in neonates， there has been a significant reduction in the incidence rate of HBV MTCT， but there is still a high risk of HBV MTCT in infants born to mothers with positive HBeAg and high viral loads. Although antiviral therapy for pregnant women with high HBV viral loads in late pregnancy can further reduce the risk of HBV MTCT， it is still difficult to completely block HBV MTCT. A deep understanding of the molecular virological mechanisms of HBV MTCT can provide clear ideas for blocking HBV MTCT， which is of great significance for the prevention and management of HBV MTCT.
- Hepatitis B Virus,
- Infectious Disease Transmission， Vertical,
- Genotype

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References(52)

References

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Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus

DOI: 10.12449/JCH241107

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Molecular virological mechanism of the mother-to-child transmission of hepatitis B virus

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