中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu
Volume 40 Issue 9
Sep.  2024
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(9): 1807-1815

Efficacy and safety of microwave ablation versus hepatic resection in treatment of hepatocellular carcinoma with liver cirrhosis： A Meta-analysis

DOI: 10.12449/JCH240915
  • 1.

    Department of Infectious Diseases，The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China

  • 2.

    School of Clinical Medicine，Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China

  • 3.

    Department of Traditional Chinese Medicine，Caojiaxiang Community Health Service Center，Chengdu 610081，China

Research funding:

Science and Technology Foundation Project of Hospital of Chengdu University of Traditional Chinese Medicine (21YY03)

More Information
  • Corresponding author: HU Xiaoyu， xiaoyuhu@aliyun.com （ORCID： 0000-0003-0187-4386）
  • Received Date: 2024-02-18
  • Accepted Date: 2024-04-01
  • Published Date: 2024-09-25
    Abstract
  •   Objective  To investigate the efficacy and safety of microwave ablation （MWA） versus hepatic resection （HR） in the treatment of hepatocellular carcinoma （HCC） with liver cirrhosis using a meta-analysis.  Methods  This study was conducted according to the PRISMA guideline， with a PROSPERO registration number of CRD42024509185. PubMed， the Cochrane Library， EMBASE， Web of Science， CNKI， VIP， and Wanfang Data were searched for randomized controlled trials （RCTs） and cohort studies on MWA versus HR in the treatment of HCC with liver cirrhosis published up to November 2023， and Stata 12.0 was used to perform the meta-analysis.  Results  A total of 3 RCTs and 5 retrospective cohort studies were included， with 953 patients in total. The meta-analysis showed that there were no differences between MWA and HR in 1-， 2-， 3-， and 5-year overall survival （OS） rates （all P>0.05） and 1-， 2-， and 5-year recurrence rates （all P>0.05）. Compared with HR， MWA had a significantly higher 3-year recurrence rate （risk ratio ［RR］=1.59， 95% confidence interval ［CI］： 1.08‍ ‍—‍ ‍2.33， P=0.017） and significantly lower 1-， 3-， and 5-year disease-free survival （DFS） rates （1-year DFS rate： RR=0.94， 95%CI： 0.89‍ ‍—‍ ‍0.99， P=0.018， I2=0.0%； 3-year DFS rate： RR=0.84， 95%CI： 0.72‍ ‍—‍ ‍0.98， P=0.023， I2=25.4%； 5-year DFS rate： RR=0.75， 95%CI： 0.58‍ ‍—‍ ‍0.98， P=0.032， I2=34.6%）. However， subgroup analysis showed that there were no significant differences between MWA and HR in 1-， 2-， and 3-year OS rates and 1- and 3-year DFS rates in the RCT subgroup （all P>0.05）. Compared with HR， MWA had significantly better intraoperative blood loss （standardized mean difference ［SMD］=-2.31， 95%CI： -2.64 to -1.97， P<0.001， I2=3.1%）， time of operation （SMD=-3.38， 95%CI： -4.05 to -2.71， P<0.001， I2=73.8%）， length of hospital stay （SMD=-2.54， 95%CI： -3.27 to -1.80， P<0.001， I2=92.8%）， adverse reactions （RR=0.42， 95%CI： 0.30‍ ‍—‍ ‍0.59， P<0.001， I2=0.0%）， and liver function （SMD=-1.43， 95%CI： -1.89‍ ‍—‍ ‍-0.97， P<0.001）.  Conclusion  There are no significant differences between MWA and HR in local recurrence， DFS， and OS， but MWA tends to have a less intraoperative blood loss， a shorter time of operation， fewer adverse reactions， a less impact on liver function， and a shorter length of hospital stay.

     

    • FullText(HTML)

  • 会议时间：2023年11月10日—14日

    会议地点：美国 波士顿

    会议网站：https://www.aasld.org/the-liver-meeting

    美国肝病学会年会是目前全世界规模最大的肝脏病学会议，历届年会均汇聚全球肝病学领域最新工作进展，每年都有来自全球100多个国家的万余名专业人士参会。本届会议主要聚焦肝炎、自身免疫性肝病、酒精性肝病、肝移植等领域的前沿进展，以大会报告、学术辩论、专家见面会、研讨会等形式，提供关于肝病的基础研究、临床研究和转化研究等领域的最新成果和信息。

    • References(37)
  • [1]
    MURAI H, KODAMA T, MAESAKA K, et al. Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma[J]. Hepatology, 2023, 77( 1): 77- 91. DOI: 10.1002/hep.32573.
    [2]
    LI BH, LI YZ, ZHOU HJ, et al. Multiomics identifies metabolic subtypes based on fatty acid degradation allocating personalized treatment in hepatocellular carcinoma[J]. Hepatology, 2024, 79( 2): 289- 306. DOI: 10.1097/HEP.0000000000000553.
    [3]
    SANKAR K, GONG J, OSIPOV A, et al. Recent advances in the management of hepatocellular carcinoma[J]. Clin Mol Hepatol, 2024, 30( 1): 1- 15. DOI: 10.3350/cmh.2023.0125.
    [4]
    HILL A, OLUMBA F, CHAPMAN W. Transplantation for hepatocellular carcinoma[J]. Surg Clin North Am, 2024, 104( 1): 103- 111. DOI: 10.1016/j.suc.2023.09.002.
    [5]
    YILMA M, MEHTA N. Optimal liver transplantation criteria for hepatocellular carcinoma[J]. Surg Oncol Clin N Am, 2024, 33( 1): 133- 142. DOI: 10.1016/j.soc.2023.06.011.
    [6]
    TRAN NH, MUÑOZ S, THOMPSON S, et al. Hepatocellular carcinoma downstaging for liver transplantation in the era of systemic combined therapy with anti-VEGF/TKI and immunotherapy[J]. Hepatology, 2022, 76( 4): 1203- 1218. DOI: 10.1002/hep.32613.
    [7]
    KARDASHIAN A, FLORMAN SS, HAYDEL B, et al. Liver transplantation outcomes in a U.S. multicenter cohort of 789 patients with hepatocellular carcinoma presenting beyond Milan criteria[J]. Hepatology, 2020, 72( 6): 2014- 2028. DOI: 10.1002/hep.31210.
    [8]
    IVANICS T, CLAASEN MPAW, SAMSTEIN B, et al. Living donor liver transplantation for hepatocellular carcinoma within and outside traditional selection criteria: A multicentric North American experience[J]. Ann Surg, 2024, 279( 1): 104- 111. DOI: 10.1097/SLA.0000000000006049.
    [9]
    CHOI J, JO C, LIM YS. Tenofovir versus entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection[J]. Hepatology, 2021, 73( 2): 661- 673. DOI: 10.1002/hep.31289.
    [10]
    ZHU P, LIAO W, ZHANG WG, et al. A prospective study using propensity score matching to compare long-term survival outcomes after robotic-assisted, laparoscopic, or open liver resection for patients with BCLC stage 0-a hepatocellular carcinoma[J]. Ann Surg, 2023, 277( 1): e103- e111. DOI: 10.1097/SLA.0000000000005380.
    [11]
    RASIC G, de GEUS SWL, BEAULIEU-JONES B, et al. A nationwide propensity score analysis comparing ablation and resection for hepatocellular carcinoma[J]. J Surg Oncol, 2023, 127( 7): 1125- 1134. DOI: 10.1002/jso.27232.
    [12]
    XU JB, QI FZ, XU G, et al. Adjuvant interferon therapy after surgical treatment for hepatitis B/C virus-related hepatocellular carcinoma: A meta-analysis[J]. Hepatol Res, 2014, 44( 2): 209- 217. DOI: 10.1111/hepr.12109.
    [13]
    YANG S, LIN Q, LIN W, et al. Effect of adjuvant interferon therapy on hepatitis B virus-related hepatocellular carcinoma: A systematic review[J]. World J Surg Oncol, 2016, 14( 1): 159. DOI: 10.1186/s12957-016-0912-7.
    [14]
    ADWAN H, HAMMANN L, VOGL TJ. Microwave ablation of recurrent hepatocellular carcinoma after curative surgical resection[J]. J Clin Med, 2023, 12( 7): 2560. DOI: 10.3390/jcm12072560.
    [15]
    RYU T, TAKAMI Y, WADA Y, et al. Combined hepatectomy and microwave ablation for multifocal hepatocellular carcinoma: Long-term outcomes and prognostic factors[J]. Asian J Surg, 2021, 44( 1): 186- 191. DOI: 10.1016/j.asjsur.2020.05.008.
    [16]
    WANG Z, LIU M, ZHANG DZ, et al. Microwave ablation versus laparoscopic resection as first-line therapy for solitary 3-5-cm HCC[J]. Hepatology, 2022, 76( 1): 66- 77. DOI: 10.1002/hep.32323.
    [17]
    WICKS JS, DALE BS, RUFFOLO L, et al. Comparable and complimentary modalities for treatment of small-sized HCC: Surgical resection, radiofrequency ablation, and microwave ablation[J]. J Clin Med, 2023, 12( 15): 5006. DOI: 10.3390/jcm12155006.
    [18]
    LIU KW, ZHENG H, SUI XZ, et al. Microwave ablation versus surgical resection for subcapsular hepatocellular carcinoma: A propensity score-matched study of long-term therapeutic outcomes[J]. Eur Radiol, 2023, 33( 3): 1938- 1948. DOI: 10.1007/s00330-022-09135-1.
    [19]
    DING WZ, YU J, LIU FY, et al. Percutaneous microwave ablation versus robot-assisted hepatectomy for early hepatocellular carcinoma: A real-world single-center study[J]. Dig Liver Dis, 2022, 54( 2): 243- 250. DOI: 10.1016/j.dld.2021.04.008.
    [20]
    TONG Y, CAI R, LI JX, et al. Liver resection versus microwave ablation for hepatocellular carcinoma in ideal candidates for ablation per Barcelona Clinic Liver Cancer staging: A propensity score matching and inverse probability of treatment weighting analysis[J]. Aliment Pharmacol Ther, 2022, 56( 11-12): 1602- 1614. DOI: 10.1111/apt.17263.
    [21]
    WANG WQ, LV X, LI J, et al. Repeat hepatectomy versus microwave ablation for solitary and small(≤3 cm) recurrent hepatocellular carcinoma with early or late recurrence: A propensity score matched study[J]. Eur J Surg Oncol, 2023, 49( 5): 1001- 1008. DOI: 10.1016/j.ejso.2022.12.016.
    [22]
    LIN YZ, SHI HY, MU XH. Diagnosis of small primary liver cancer under the background of liver cirrhosis by dual-source CT hepatic artery three-phase scanning and enhanced perfusion scanning[J]. J Pract Hepatol, 2023, 26( 3): 412- 415. DOI: 10.3969/j.issn.1672-5069.2023.03.028.

    林永祝, 史红媛, 穆西虎. 双源CT肝动脉三期扫描和增强灌注扫描诊断肝硬化背景下小原发性肝癌价值研究[J]. 实用肝脏病杂志, 2023, 26( 3): 412- 415. DOI: 10.3969/j.issn.1672-5069.2023.03.028.
    [23]
    HE J, CHEN WQ, SHEN HB, et al. China guideline for liver cancer screening(2022, Beijing)[J]. J Clin Hepatol, 2022, 38( 8): 1739- 1758. DOI: 10.3969/j.issn.1001-5256.2022.08.007.

    赫捷, 陈万青, 沈洪兵, 等. 中国人群肝癌筛查指南(2022, 北京)[J]. 临床肝胆病杂志, 2022, 38( 8): 1739- 1758. DOI: 10.3969/j.issn.1001-5256.2022.08.007.
    [24]
    ZHANG QB, ZHANG XG, JIANG RD, et al. Microwave ablation versus hepatic resection for the treatment of hepatocellular carcinoma and oesophageal variceal bleeding in cirrhotic patients[J]. Int J Hyperthermia, 2017, 33( 3): 255- 262. DOI: 10.1080/02656736.2016.1257824.
    [25]
    ZHANG EL, YANG F, WU ZB, et al. Therapeutic efficacy of percutaneous microwave coagulation versus liver resection for single hepatocellular carcinoma ≤3 cm with Child-Pugh A cirrhosis[J]. Eur J Surg Oncol, 2016, 42( 5): 690- 697. DOI: 10.1016/j.ejso.2016.02.251.
    [26]
    YANG F, ZHANG EL, XIAO ZY, et al. Therapeutic outcomes of surgical resection versus percutaneous microwave coagulation therapy for single small hepatocellular carcinoma with cirrhosis(250 cases)[J]. Acta Med Univ Sci Technol Huazhong, 2016, 45( 2): 185- 189. DOI: 10.3870/j.issn.1672-0741.2016.02.014.

    杨藩, 张二雷, 肖震宇, 等. 经皮微波消融与手术切除治疗合并肝硬化的单发小肝癌的疗效比较(附250例)[J]. 华中科技大学学报(医学版), 2016, 45( 2): 185- 189. DOI: 10.3870/j.issn.1672-0741.2016.02.014.
    [27]
    HUANG Y, CHEN J, LIU XS. Clinical efficacy of laparoscopic microwave ablation in the treatment of small hepatocellular carcinoma with cirrhosis[J]. Chin J Minim Invasive Surg, 2017, 17( 6): 504- 508. DOI: 10.3969/j.issn.1009-6604.2017.06.008.

    黄炎, 陈坚, 刘绪舜. 腹腔镜微波消融治疗小肝癌合并肝硬化的临床疗效[J]. 中国微创外科杂志, 2017, 17( 6): 504- 508. DOI: 10.3969/j.issn.1009-6604.2017.06.008.
    [28]
    LIAO LF, XUE JZ, LI SK. Survival analysis of percutan eous microwave ablation for patients with small hepatocellular carcinoma with underlying liver cirrhosis[J]. J Pract Hepatol, 2018, 21( 2): 257- 260. DOI: 10.3969/j.issn.1672-5069.2018.02.025.

    廖凌峰, 薛建章, 李士坤. 经皮微波消融术治疗合并肝硬化的原发性小肝癌患者生存分析[J]. 实用肝脏病杂志, 2018, 21( 2): 257- 260. DOI: 10.3969/j.issn.1672-5069.2018.02.025.
    [29]
    CHEN HJ, CHEN Y, ZHANG SQ, et al. Comparison of microwave ablation and surgical resection in the treatment of 92 cases of small hepatocellular carcinoma complicated with cirrhosis[J]. Med J Commun, 2018, 32( 2): 163- 165.

    陈红健, 陈橼, 张素青, 等. 微波消融与手术切除治疗小肝癌合并肝硬化92例效果比较[J]. 交通医学, 2018, 32( 2): 163- 165.
    [30]
    WANG HP, JIA J. Comparative analysis of microwave ablation and surgical resection in the treatment of 90 cases of small hepatocellular carcinoma complicated with cirrhosis[J/CD]. Electron J Clin Med Lit, 2019, 6( 94): 52. DOI: 10.16281/j.cnki.jocml.2019.94.043.

    王辉坡, 贾静. 微波消融与手术切除治疗小肝癌合并肝硬化90例效果对比分析[J/CD]. 临床医药文献电子杂志, 2019, 6( 94): 52. DOI: 10.16281/j.cnki.jocml.2019.94.043.
    [31]
    HUANG ZM, ZHU CH, LI J. Clinical observation of microwave ablation and surgical resection in the treatment of small hepatocellular carcinoma with resectable cirrhosis[J]. Shenzhen J Integr Tradit Chin West Med, 2016, 26( 23): 16- 18, 199. DOI: 10.16458/j.cnki.1007-0893.2016.23.008.

    黄志明, 朱灿华, 李君. 微波消融与手术切除治疗可切除肝硬化型初治小肝癌的疗效观察[J]. 深圳中西医结合杂志, 2016, 26( 23): 16- 18, 199. DOI: 10.16458/j.cnki.1007-0893.2016.23.008.
    [32]
    WELLS G, SHEA B, O’CONNELL D, et al. The Newcastle-Ottawa Scale(NOS) for assessing the quality of nonrandomised studies in meta-analyses[EB/OL]. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. http: //www.ohri.ca/programs/clinical_epidemiology/oxford.asp
    [33]
    HIGGINS J, THOMAS J, CHANDLER J, et al. Cochrane Handbook for Systematic Reviews of Interventions Version 6.3, 2022[EB/OL]. http://training.cochrane.org/handbook/current. http: //training.cochrane.org/handbook/current
    [34]
    General Office of National Health Commission. Standard for diagnosis and treatment of primary liver cancer(2022 edition)[J]. J Clin Hepatol, 2022, 38( 2): 288- 303. DOI: 10.3969/j.issn.1001-5256.2022.02.009.

    国家卫生健康委办公厅. 原发性肝癌诊疗指南(2022年版)[J]. 临床肝胆病杂志, 2022, 38( 2): 288- 303. DOI: 10.3969/j.issn.1001-5256.2022.02.009.
    [35]
    XIONG K, ZHU LP, LU Y, et al. Network Meta-analysis on the efficacy and safety of surgical resection and thermal ablations for hepatocellular carcinoma in China[J]. Chin J Hepatobiliary Surg, 2019, 25( 11): 823- 827. DOI: 10.3760/cma.j.issn.1007-8118.2019.11.007.

    熊琨, 朱莉萍, 陆勇, 等. 我国肝细胞癌手术切除与热消融疗效和安全性比较的网络荟萃分析[J]. 中华肝胆外科杂志, 2019, 25( 11): 823- 827. DOI: 10.3760/cma.j.issn.1007-8118.2019.11.007.
    [36]
    ZHANG T, HU H, JIA YS, et al. Efficacy and safety of radiofrequency ablation and surgery for hepatocellular carcinoma in patients with cirrhosis: A meta-analysis[J]. Medicine, 2022, 101( 52): e32470. DOI: 10.1097/MD.0000000000032470.
    [37]
    WANG WX, ZHANG FZ, XU XX, et al. Comparison on efficacy of TACE combined with radiofrequency ablation or microwave ablation for primary hepatocellular carcinoma: Meta-analysis[J]. Chin J Interv Imag Ther, 2023, 20( 8): 467- 472. DOI: 10.13929/j.issn.1672-8475.2023.08.005.

    王文轩, 张福洲, 徐晓雪, 等. 对比TACE联合射频消融与联合微波消融治疗原发性肝细胞癌效果:Meta分析[J]. 中国介入影像与治疗学, 2023, 20( 8): 467- 472. DOI: 10.13929/j.issn.1672-8475.2023.08.005.
    • Relative Articles

  • Relative Articles

    [1]Kaifeng YAN, Xiaojie HU, Hong LIU. Clinical efficacy of liver venous deprivation versus portal vein embolization in treatment of liver cancer with insufficient residual liver volume： A Meta-analysis[J]. Journal of Clinical Hepatology, 2024, 40(12): 2464-2472. doi: 10.12449/JCH241217
    [2]Shao CuiPing, Xu YouQing. Correlation between serum CA125 level and severity of liver dysfunction in patients with liver cirrhosis: A Meta-analysis[J]. Journal of Clinical Hepatology, 2019, 35(4): 796-800. doi: 10.3969/j.issn.1001-5256.2019.04.018
    [3]Hou Jie, Liu LiXin. Effect of probiotics in treatment of nonalcoholic fatty liver disease: A Meta-analysis[J]. Journal of Clinical Hepatology, 2018, 34(12): 2624-2630. doi: 10.3969/j.issn.1001-5256.2018.12.023
    [4]Zhang YanFang, Yang FuNing, Che YuanYuan, Huang Jing. Diagnostic value of serum YKL-40 for liver fibrosis stage: A meta-analysis[J]. Journal of Clinical Hepatology, 2018, 34(9): 1896-1900. doi: 10.3969/j.issn.1001-5256.2018.09.014
    [5]Sun YuanPei, Guo XiaoXia. Clinical effect of probiotics in treatment of liver cirrhosis: a Meta-analysis[J]. Journal of Clinical Hepatology, 2018, 34(1): 73-79. doi: 10.3969/j.issn.1001-5256.2018.01.015
    [6]Mo XiaoLi, Liu Jie, Zhu JiaYu, Chen Chuang, Ou Jie, Mao SuFei. Value of transforming growth factor-β1 in diagnosis of primary liver cancer:a meta-analysis[J]. Journal of Clinical Hepatology, 2017, 33(5): 864-868. doi: 10.3969/j.issn.1001-5256.2017.05.014
    [7]Wu Yue, Huang LiPing. Value of real-time shear wave elastography in evaluating classification of liver fibrosis: a Meta-analysis[J]. Journal of Clinical Hepatology, 2017, 33(9): 1717-1721. doi: 10.3969/j.issn.1001-5256.2017.09.017
    [8]Zhao Jian, Li Wei, Liang CaiQuan, Yao DingKang. Liver cirrhosis and the risk of fracture: a Meta-analysis[J]. Journal of Clinical Hepatology, 2017, 33(6): 1112-1115. doi: 10.3969/j.issn.1001-5256.2017.06.019
    [9]Li Mi, Nie QingHe. Accuracy of Fibro Scan for diagnosis of primary liver cancer: a Meta-analysis[J]. Journal of Clinical Hepatology, 2016, 32(2): 312-316. doi: 10.3969/j.issn.1001-5256.2016.02.023
    [10]Mao HaiYing, Kang Tao, Yao Ling, Chen Qin. Efficacy of glycyrrhizin in patients with chronic severe hepatitis B:a meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(1): 63-67. doi: 10.3969/j.issn.1001-5256.2015.01.014
    [11]Yin Yu, Ni CaiFang, Li Zhi, Tang Jie. Therapeutic comparison between radiofrequency ablation and percutaneous ethanol injection in treatment of primary liver cancer: a meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(6): 918-921. doi: 10.3969/j.issn.1001-5256.2015.06.022
    [12]Fan YunYu, Sun LingYun. Association between smoking and risk of primary biliary cirrhosis: a meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(10): 1625-1629. doi: 10.3969/j.issn.1001-5256.2015.10.016
    [13]Li Xia, Shi YongYu. Correlation between interleukin-6 and primary hepatocellular carcinoma: a meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(6): 936-942. doi: 10.3969/j.issn.1001-5256.2015.06.026
    [14]Yu Yuan, Yang ZongGuo, Chen ChiChi, Lu YunFei, Xu QingNian, Chen XiaoRong. Efficacy of adjuvant therapy with fenofibrate for primary biliary cirrhosis: a Meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(10): 1630-1633. doi: 10.3969/j.issn.1001-5256.2015.10.017
    [15]Zhang YuHuai, Luo ZhangJiang. Efficacy and safety of octreotide in treatment of hepatocellular carcinoma: a meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(6): 922-926. doi: 10.3969/j.issn.1001-5256.2015.06.023
    [16]Zhang WenWen, Qi XingShun, Guo XiaoZhong. Mirabilite umbilical compress in treatment of ascites in liver cirrhosis: a meta-analysis[J]. Journal of Clinical Hepatology, 2015, 31(6): 947-950. doi: 10.3969/j.issn.1001-5256.2015.06.028
    [17]Yin TianSheng, Yi YaYang, Mao XiXian, Li DeWei. Meta-analysis of risk factors for posthepatectomy liver failure in patients with hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2014, 30(10): 1009-1014. doi: 10.3969/j.issn.1001-5256.2014.10.009
    [18]Chen XiaoHong, Wu ZongYing, Wang YiPing, Ceng Chao, Pan Tao. Fatality and adverse event rates of prostaglandin E in treating acute liver failure: a meta- analysis[J]. Journal of Clinical Hepatology, 2013, 29(9): 681-684. doi: 10.3969/j.issn.1001-5256.2013.09.012
    [19]Ye Gang, Ma Yu, Tang ChengJia, Du ChengYou. Clinical outcomes of laparoscopic hepatectomy and open hepatectomy for hepatocellular carcinoma: A meta-analysis[J]. Journal of Clinical Hepatology, 2013, 29(3): 184-190.
    [20]Song LiWen, Zhao GuiMing, Cao WuKui, Lu ChengZhen. Meta analysis of the comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B[J]. Journal of Clinical Hepatology, 2011, 27(9): 955-961.
    • Supplements(0)
    • Cited By
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-04020406080
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 22.2 %FULLTEXT: 22.2 %META: 71.3 %META: 71.3 %PDF: 6.5 %PDF: 6.5 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 9.0 %其他: 9.0 %其他: 0.4 %其他: 0.4 %Russian Federation: 0.2 %Russian Federation: 0.2 %San Mateo: 0.2 %San Mateo: 0.2 %Tiruchi: 0.2 %Tiruchi: 0.2 %上海: 2.1 %上海: 2.1 %六安: 0.4 %六安: 0.4 %凉山: 0.4 %凉山: 0.4 %北京: 2.9 %北京: 2.9 %华盛顿州: 0.2 %华盛顿州: 0.2 %南京: 0.4 %南京: 0.4 %南宁: 0.2 %南宁: 0.2 %南通: 0.2 %南通: 0.2 %卡纳塔克: 0.2 %卡纳塔克: 0.2 %咸阳: 0.2 %咸阳: 0.2 %大克罗伊茨: 0.4 %大克罗伊茨: 0.4 %天津: 0.6 %天津: 0.6 %奎松: 0.2 %奎松: 0.2 %山景城: 0.2 %山景城: 0.2 %常州: 0.2 %常州: 0.2 %常德: 0.4 %常德: 0.4 %平顶山: 0.2 %平顶山: 0.2 %广州: 0.8 %广州: 0.8 %张家口: 4.4 %张家口: 4.4 %悉尼: 0.2 %悉尼: 0.2 %成都: 1.9 %成都: 1.9 %日照: 0.4 %日照: 0.4 %昆明: 0.2 %昆明: 0.2 %杭州: 0.8 %杭州: 0.8 %梅州: 0.6 %梅州: 0.6 %武汉: 1.3 %武汉: 1.3 %永州: 0.2 %永州: 0.2 %济南: 0.4 %济南: 0.4 %海得拉巴: 0.2 %海得拉巴: 0.2 %淄博: 0.2 %淄博: 0.2 %温州: 0.6 %温州: 0.6 %漯河: 0.6 %漯河: 0.6 %潍坊: 0.2 %潍坊: 0.2 %烟台: 0.4 %烟台: 0.4 %焦作: 0.4 %焦作: 0.4 %石家庄: 0.4 %石家庄: 0.4 %科泽科德: 0.2 %科泽科德: 0.2 %芒廷维尤: 35.6 %芒廷维尤: 35.6 %芝加哥: 2.9 %芝加哥: 2.9 %苏州: 0.8 %苏州: 0.8 %莫斯科: 0.8 %莫斯科: 0.8 %衢州: 0.4 %衢州: 0.4 %襄阳: 0.2 %襄阳: 0.2 %西宁: 7.9 %西宁: 7.9 %西安: 0.4 %西安: 0.4 %诺沃克: 0.2 %诺沃克: 0.2 %贵阳: 0.4 %贵阳: 0.4 %资阳: 0.2 %资阳: 0.2 %赣州: 0.2 %赣州: 0.2 %运城: 0.6 %运城: 0.6 %遵义: 0.2 %遵义: 0.2 %郑州: 1.0 %郑州: 1.0 %重庆: 0.8 %重庆: 0.8 %长春: 11.5 %长春: 11.5 %长沙: 0.6 %长沙: 0.6 %长治: 0.2 %长治: 0.2 %韶关: 0.2 %韶关: 0.2 %黄冈: 0.2 %黄冈: 0.2 %其他其他Russian FederationSan MateoTiruchi上海六安凉山北京华盛顿州南京南宁南通卡纳塔克咸阳大克罗伊茨天津奎松山景城常州常德平顶山广州张家口悉尼成都日照昆明杭州梅州武汉永州济南海得拉巴淄博温州漯河潍坊烟台焦作石家庄科泽科德芒廷维尤芝加哥苏州莫斯科衢州襄阳西宁西安诺沃克贵阳资阳赣州运城遵义郑州重庆长春长沙长治韶关黄冈

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (341) PDF downloads(31) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[2389]YesterdayPV[5285]TodayIP[2086]TodayPV[4573]Online[52]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return