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Volume 40 Issue 1
Jan.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(1): 147-150

The mechanism of action of mitochondrial dysfunction in the development of non-alcoholic fatty liver disease

DOI: 10.12449/JCH240124

  • Center of Liver Diseases，Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China

Research funding:

National Natural Science Foundation of China (82170591)

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  • Corresponding author: WANG Qi， wangqidl04@ccmu.edu.cn （ORCID： 0000-0002-0269-1568）
  • Received Date: 2023-04-17
  • Accepted Date: 2023-06-19
  • Published Date: 2024-01-23
    Abstract
  • Nonalcoholic fatty liver disease （NAFLD） has gradually become the main reason affecting human liver health， and many factors are involved in the development and progression of NAFLD. Mitochondria， as the “energy factory” of cells， plays an important role in maintaining normal physiological functions. Studies have shown that hepatic mitochondrial dysfunction promotes the development and progression of NAFLD. This article briefly introduces the latest research advances in the basic characteristics and physiological function of liver mitochondria and reviews new research findings in the association of mitochondrial dysfunction with obesity， simple fatty liver disease， and nonalcoholic steatohepatitis， in order to provide new ideas for the research on targeted mitochondrial therapy for NAFLD.

     

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