2021 No. 7

2021 No.7

Theme Issue: Concomitant chronic hepatitis B virus infection and nonalcoholic fatty liver disease

Executive Chief Editor: Zhao Jingmin

The Fifth Medical Center of Chinese PLA General Hospital

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Editorial

Current status and perspectives of the clinical and basic research on concomitant chronic hepatitis B virus infection and nonalcoholic fatty liver disease

Lina JIANG, Wei Li, Jingmin ZHAO

2021, 37(7): 1489-1494. DOI: 10.3969/j.issn.1001-5256.2021.07.001

Abstract(1033)

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Abstract:
Chronic hepatitis B virus infection (CBI) and nonalcoholic fatty liver disease (NAFLD) are the two main etiologies of chronic liver diseases worldwide, and therefore, concomitant CBI and NAFLD (Co-CBI&NAFLD) is relatively common. There are still controversies over the influence of the interactio...

Discussions by experts

Interaction between hepatitis B virus replication and lipid metabolism in patients with chronic hepatitis B and NAFLD

Xiajie WEN, Guixin LI, Jie LI, Huiying RAO, Jidong JIA, Fengmin LU

2021, 37(7): 1495-1500. DOI: 10.3969/j.issn.1001-5256.2021.07.002

Abstract(2041)

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There is still a large number of patients with chronic hepatitis B virus (HBV) infection in China, which greatly affects the health of Chinese people. With the change in lifestyle, the incidence rate of nonalcoholic fatty liver disease (NAFLD) is increasing year by year in China. Some clinical studi...

Natural history and non-invasive diagnosis and clinical management of chronic HBV infection overlapping with nonalcoholic fatty liver disease

Liang XU, Ping LI, Lin CHEN, Yuqiang FU

2021, 37(7): 1501-1507. DOI: 10.3969/j.issn.1001-5256.2021.07.003

Abstract(956)

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Abstract:
Chronic HBV infection (CBI) overlapping with nonalcoholic fatty liver disease (NAFLD) is becoming more and more common. Most studies about the influence of overlapping with NAFLD on the natural history of CBI have shown that overlapping with NAFLD promotes not only the development of cirrhosis and h...

Chronic hepatitis B virus infection with nonalcoholic fatty liver disease: Problems faced by antiviral therapy

Yanhua TANG, Xingyu LU, Jian SUN

2021, 37(7): 1508-1514. DOI: 10.3969/j.issn.1001-5256.2021.07.004

Abstract(914)

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Abstract:
With an increase in the incidence rate of nonalcoholic fatty liver diseases (NAFLD), chronic hepatitis B virus (HBV) infection with NAFLD has become more and more common in clinical practice. In case of elevated alanine aminotransferase, identification of the underlying cause and timely implementati...

Role of mitochondrial injury in the development and progression of nonalcoholic fatty liver disease

Weichun XIAO, Wei AN

2021, 37(7): 1515-1521. DOI: 10.3969/j.issn.1001-5256.2021.07.005

Abstract(2250)

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Abstract:
Mitochondria are an important organelle and can regulate lipid metabolism, oxidative phosphorylation, and ATP synthesis. Disorder of mitochondria biosynthesis, loss of mitochondrial homeostasis, and even mitochondrial structural damage will lead to lipid metabolism disorders and oxidative stress. No...

Hotspot·Perspective·Viewpoint

Global elimination of viral hepatitis as a public health threat: Promoting diagnosis and treatment is the key to reducing mortality

Fuqiang CUI

2021, 37(7): 1522-1524. DOI: 10.3969/j.issn.1001-5256.2021.07.006

Abstract(912)

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Abstract:
According to Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021 - Accountability for the global health sector strategies 2016-2021: Actions for impact, released by WHO on May 20, 2021, there is still an estimated number of 296 million people with hepatitis B vir...

Academic contention

Diagnostic criteria should be reevaluated in immune-tolerant phase of chronic hepatitis B virus infection and research should be focused on the population aged > 35 years

Yihua ZHOU

2021, 37(7): 1525-1526. DOI: 10.3969/j.issn.1001-5256.2021.07.007

Abstract(541)

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"Treat All" is not recommended in chronic HBV infection patients with normal ALT

Airong HU, Yaoren HU

2021, 37(7): 1527-1527. DOI: 10.3969/j.issn.1001-5256.2021.07.008

Abstract(677)

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Thoughts on recommendations for immune-tolerant phase of chronic hepatitisB virus infection in Guidelines for the management of hepatitis B (version 3.3) released by the Japan Society of Hepatology

Aiping WANG, Chunyang WEN

2021, 37(7): 1528-1528. DOI: 10.3969/j.issn.1001-5256.2021.07.009

Abstract(880)

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Value of a nomogram model in predicting significant liver injury in patients with immune-tolerant phase chronic hepatitis B

Chunyan WANG, Wucai YANG, Wenhui TAN, Ya DENG, Chang GUO, Shan ZHANG, Jianjun WANG, Guofeng CHEN, Dong JI

2021, 37(7): 1529-1533. DOI: 10.3969/j.issn.1001-5256.2021.07.010

Abstract(1018)

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Abstract:
Objective To investigate the high-risk factors for significant liver injury in patients with immune-tolerant phase chronic hepatitis B (IT-CHB), and to establish a nomogram predictive model. Methods A retrospective analysis was performed for the data of 382 patients with chronic HBV infection who un...

Guidelines

In-hospital process for viral hepatitis C screening and management in China (Draft)

China Liver Health, Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Laboratory Medicine, Chinese Medical Association, Hospital Infection Management Committee of Chinese Hospital Association

2021, 37(7): 1534-1539. DOI: 10.3969/j.issn.1001-5256.2021.07.011

Abstract(936)

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Abstract:
Viral hepatitis C is one of the important causes of liver cirrhosis and hepatocellular carcinoma. There are approximately 10 million cases of chronic hepatitis C virus (HCV) infection in China. However, over 70% of HCV infections of China have not yet been detected. According to the goal of "elimina...

Expert consensus on standardized treatment of decompensated liver cirrhosis with stem cell transplantation (2021)

Group of Stem Cell Engineering, Medical Engineering Society of Chinese Medical Association

2021, 37(7): 1540-1544. DOI: 10.3969/j.issn.1001-5256.2021.07.012

Abstract(1520)

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Expert consensus on integrated traditional Chinese and Western medicine rehabilitation after transcatheter arterial chemoembolization for primary liver cancer

National Science and Technology Major Project of the Ministry of Science and Technology of China-Prevention and Treatment of Major Infectious Diseases such as AIDS and Viral Hepatitis-Research Group of "Comprehensive Treatment Plan for Retarding Hepatitis B Related Liver Cancer Progression with Traditional Chinese Medicine", Oncology Expert Committee of Integrated Traditional Chinese and Western Medicine Branch of Chinese Medical Doctor Association, Digestive Rehabilitation Branch of Henan Rehabilitation Medical Association, Liver Disease Branch of Henan Society of Integrated Traditional Chinese and Western Medicine

2021, 37(7): 1545-1549. DOI: 10.3969/j.issn.1001-5256.2021.07.013

Abstract(911)

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An excerpt of EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients (2021)

Jiabao GENG, Yuecheng YU

2021, 37(7): 1550-1552. DOI: 10.3969/j.issn.1001-5256.2021.07.014

Abstract(660)

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Abstract:

Guideline interpretation

Interpretation of European Society for Clinical Nutrition and Metabolism practical guideline : Clinical nutrition in liver disease (2020)

Dandan JIA, Guiying ZHU, Shiyao LIAO, Hui ZHANG, Hui GUO, Lili YANG, Changmiao WANG

2021, 37(7): 1553-1557. DOI: 10.3969/j.issn.1001-5256.2021.07.015

Abstract(1421)

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Abstract:
In December 2020, European Society for Clinical Nutrition and Metabolism (ESPEN) issued the latest practical guidelines for clinical nutrition in liver disease on the basis of the published ESPEN guidelines for clinical nutrition in liver disease and the latest clinical evidence. The guideline propo...

Original articles_Viral hepatitis

Clinical follow-up of children with immune-tolerant chronic hepatitis B receiving antiviral therapy

Pan ZHAO, Yi DONG, Jiaqi LIU, Xue GAO, Yiwei WU, Shishu ZHU, Limin WANG, Zhenman WEI

2021, 37(7): 1558-1560. DOI: 10.3969/j.issn.1001-5256.2021.07.016

Abstract(742)

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Abstract:
Objective To investigate the long-term clinical benefits of antiviral therapy in children with immune-tolerant chronic hepatitis B. Methods Long-term follow-up was performed for 46 children with immune-tolerant chronic hepatitis B who were enrolled in the treatment group of the previous randomized c...

Effect of hepatitis B x gene-overexpressed hepatocytes on the proliferation and activation of hepatic stellate cells and related mechanism

Tingyu REN, Hezhongrong NIE, Lijia XIAO, Fangnan LIN, Daming WANG, Chunli SONG, Yiwen ZHOU

2021, 37(7): 1561-1566. DOI: 10.3969/j.issn.1001-5256.2021.07.017

Abstract(1009)

HTML (307)

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Abstract:
Objective To investigate the effect of hepatitis B virus (HBV) infection on the activation of hepatic stellate cells (HSCs) and its mechanism of action. Methods A total of 30 plasma samples of chronic hepatitis B patients, 42 plasma samples of hepatitis B cirrhosis patients, 30 plasma samples of hep...

Original articles_Liver fibrosis and liver cirrhosis

Value of five noninvasive serum models in the diagnosis of chronic hepatitis B liver fibrosis

Xinlan ZHOU, Yanbing WANG, Wei LU, Xiufang LI, Dan HUANG, Zhanqing ZHANG, Rongrong DING

2021, 37(7): 1567-1571. DOI: 10.3969/j.issn.1001-5256.2021.07.018

Abstract(1086)

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Abstract:
Objective To investigate the value of aspartate aminotransferase-to-platelet count ratio index (APRI), fibrosis-4 (FIB-4) score, gamma-glutamyl transpeptidase-to-platelet ratio (GPR), Göteborg University Cirrhosis Index (GUCI) score, and King's score in assessing liver fibrosis stage in patients wit...

Value of spleen stiffness measured by two-dimensional shear wave elastography combined with platelet count/spleen diameter ratio in evaluating moderate-to-severe gastroesophageal varices in patients with hepatitis B cirrhosis

Minrui YU, Jie YANG, Jinyong WANG, Bo ZHOU, Bin JIANG, Baocheng DENG

2021, 37(7): 1572-1577. DOI: 10.3969/j.issn.1001-5256.2021.07.019

Abstract(830)

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Abstract:
Objective To establish a noninvasive diagnostic model for moderate-to-severe gastroesophageal varices (GEV) in patients with hepatitis B cirrhosis. Methods The patients with hepatitis B cirrhosis who attended The First Affiliated Hospital of China Medical University from October 2017 to December 201...

Value of platelet-albumin-bilirubin score in predicting the short-term prognosis of patients with liver cirrhosis and acute upper gastrointestinal bleeding

Chen XU, Miao JIANG

2021, 37(7): 1578-1581. DOI: 10.3969/j.issn.1001-5256.2021.07.020

Abstract(1024)

HTML (201)

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Abstract:
Objective To investigate the value of platelet-albumin-bilirubin score (PALBI) in predicting the 30-day mortality of patients with liver cirrhosis and acute upper gastrointestinal bleeding (AUGIB). Methods A retrospective analysis was performed for the clinical data of 211 patients with liver cirrho...

Role of thromboelastography in assessing the risk of spontaneous bleeding in patients with liver cirrhosis

Decui PEI, Sisi WEN, Haichun HU, Xiuxia ZHENG, Linfei LI, Jiewen DENG

2021, 37(7): 1582-1588. DOI: 10.3969/j.issn.1001-5256.2021.07.021

Abstract(578)

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Abstract:
Objective To investigate the association between thromboelastography (TEG) parameters and bleeding in patients with liver cirrhosis and whether TEG can be used to predict the risk of spontaneous bleeding in patients with liver cirrhosis, and to provide a basis for its preventive treatment. Methods A...

Original articles_Liver neoplasms

Risk factors for hepatocellular carcinoma in patients with chronic hepatitis B

Long LIU, Ke SHI, Qun ZHANG, Chongping RAN, Jie HOU, Yi ZHANG, Xianbo WANG

2021, 37(7): 1589-1593. DOI: 10.3969/j.issn.1001-5256.2021.07.022

Abstract(1085)

HTML (142)

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Abstract:
Objective To investigate the risk factors for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Methods A total of 1239 patients who were diagnosed with CHB in Beijing Ditan Hospital from January 2013 to June 2015 and were followed up for more than 3 years were enrolled, amo...

Effectiveness and safety of ultrasound-guided ablation in treatment of primary liver cancer in dangerous areas

Ting WANG, Chunyan WANG, Jianyong LIU, Yonghe ZHOU, Wei LU, Jia LI, Li ZHOU

2021, 37(7): 1594-1598. DOI: 10.3969/j.issn.1001-5256.2021.07.023

Abstract(476)

HTML (139)

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Abstract:
Objective To investigate the effectiveness and safety of ultrasound-guided percutaneous local ablation in the treatment of liver cancer in dangerous areas. Methods A total of 179 patients with primary liver cancer who were admitted to Tianjin Second People's Hospital from January 2014 to September 2...

Expression of nucleolar spindle-associated protein 1 in hepatocellular carcinoma and its effect on clinical prognosis: A bioinformatics analysis

Xinmin JIN, Tongwang YANG, Qingguo XU, Huan LIU, Ge GUAN, Yunjin ZANG

2021, 37(7): 1599-1602. DOI: 10.3969/j.issn.1001-5256.2021.07.024

Abstract(858)

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Abstract:
Objective To investigate the expression of the nucleolar spindle-associated protein 1 (NUSAP1) gene in hepatocellular carcinoma (HCC) and its effect on clinical prognosis. Methods HCC microarray datasets GSE57957, GSE14520, GSE22058, GSE46444, GSE54236, GSE36376, GSE64041, GSE76297, GSE76427, and GS...

Original articles_Other liver diseases

Clinical features of children with hepatitis and granulocytopenia and risk factors for progression to aplastic anemia

Lili CAO, Jianguo YAN, Yi DONG, Shishu ZHU, Zhiqiang XU, Fuchuan WANG, Pu WANG, Aiqin LI, Limin WANG, Min ZHANG

2021, 37(7): 1603-1608. DOI: 10.3969/j.issn.1001-5256.2021.07.025

Abstract(872)

HTML (126)

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Abstract:
Objective To investigate the incidence rate and clinical features of children with hepatitis and granulocytopenia and the risk factors for progression to aplastic anemia (AA). Methods A retrospective analysis was performed for 2944 children, aged ≤18 years, who were hospitalized due to abnormal live...

The change in the prevalence of fatty liver disease and related influencing factors among Karamay residents in 2009-2016 and related influencing factors

Jiang DENG, Yonghong ZHANG, Shuangsuo DANG, Yatao WANG, Haitao SHI, Limei BU, Zhiyi HAN, Xiaolan LU

2021, 37(7): 1609-1613. DOI: 10.3969/j.issn.1001-5256.2021.07.026

Abstract(523)

HTML (167)

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Abstract:
Objective To investigate the change in the prevalence rate of fatty liver disease (FLD) and related influencing factors among individuals undergoing physical examination in Karamay Central Hospital from 2009 to 2016, and to provide a reference for the prevention and treatment of FLD. Methods Abdomin...

Establishment of a model for evaluating the severity of nonalcoholic fatty liver disease based on transient elastography parameters

Mingjie YAO, Xiajie WEN, Leijie WANG, Qiong HE, Jianwen LUO, Jiangao FAN, Qing XIE, Chengwei CHEN, Qing Chun FU, Jun Ping SHI, Yongfeng YANG, Yun XU, Lungen LU, Fengmin LU

2021, 37(7): 1614-1618. DOI: 10.3969/j.issn.1001-5256.2021.07.027

Abstract(967)

HTML (228)

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Abstract:
Objective To establish a model for evaluating the severity of nonalcoholic fatty liver disease (NAFLD) based on a combined analysis of transient elastography parameters. Methods A retrospective analysis was performed for the clinical information and liver elasticity parameters of 184 NAFLD patients ...

Association of nonalcoholic fatty liver disease with the risk of colorectal adenoma and colorectal cancer: A Meta-analysis

Huaqiang ZHANG, Lixin LIU, Xiaohong GUO

2021, 37(7): 1619-1625. DOI: 10.3969/j.issn.1001-5256.2021.07.028

Abstract(762)

HTML (170)

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Abstract:
Objective To systematically evaluate the association of the presence and severity of nonalcoholic fatty liver disease (NAFLD) with the risk of colorectal adenoma (CRA) and colorectal cancer (CRC). Methods PubMed, Embase, Web of Science, The Cochrane Library, CNKI, Wanfang Data, and VIP databases wer...

Clinical features of elderly patients with drug-induced liver failure: An analysis of 65 cases

Liping WANG, Tingting HE, Yanfei CUI, Zhongxia WANG, Yun ZHU, Jing JING, Yongqiang SUN, Wentao XU, Simiao YU, Xiuxiu SANG, Miao TIAN, Lifu WANG, Ruilin WANG

2021, 37(7): 1626-1631. DOI: 10.3969/j.issn.1001-5256.2021.07.029

Abstract(731)

HTML (275)

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Abstract:
Objective To investigate the features and medication of elderly patients with drug-induced liver failure (DILF), and to provide a reference for clinical prevention and treatment of DILF in elderly patients. Methods A total of 65 elderly patients, aged ≥60 years, who were diagnosed with DILF in The F...

Value of high-density lipoprotein cholesterol in evaluating the severity and prognosis of hepatitis B virus-associated acute-on-chronic liver failure

Ying XU, Xiaoping HUANG, Li CHEN, Wei SUN, Wenting LI, Yan WANG, Jianhe GAN

2021, 37(7): 1632-1635. DOI: 10.3969/j.issn.1001-5256.2021.07.030

Abstract(545)

HTML (179)

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Abstract:
Objective To investigate the association of high-density lipoprotein cholesterol (HDL-C) with the prognosis of hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) and its predictive value. Methods The patients with liver disease who were admitted to Department of Infectious Diseas...

Clinical features and prognosis of autoimmune hepatitis patients with different sexes

Huili WU, Hongbo SHI, Yanmin LIU, Mei DING, Zhenglai MA, Shuang LIU, Yu CHEN, Zhongping DUAN

2021, 37(7): 1636-1643. DOI: 10.3969/j.issn.1001-5256.2021.07.031

Abstract(668)

HTML (159)

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Abstract:
Objective To investigate the differences between autoimmune hepatitis (AIH) patients with different sexes, since AIH is more common in female individuals and there are few studies on male AIH patients. Methods A retrospective analysis was performed for 398 patients who were hospitalized in Beijing Y...

Original articles_Biliary diseases

Efficacy and safety of SpyGlass system combined with electrohydraulic lithotripsy during endoscopic retrograde cholangiopancreatography in treatment of difficult common bile duct stones

Yijun LIU, Qiao WU

2021, 37(7): 1644-1647. DOI: 10.3969/j.issn.1001-5256.2021.07.032

Abstract(1114)

HTML (416)

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Abstract:
Objective To investigate the efficacy and safety of SpyGlass system combined with electrohydraulic lithotripsy during endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of difficult common bile duct stones. Methods A total of 20 patients who used the SpyGlass system combined with...

Original articles_Pancreatic diseases

Value of contrast-enhanced endoscopic ultrasound versus contrast-enhanced computed tomography in the diagnosis of pancreatic solid space-occupying lesions

Jing LI, Xin LI, Hui ZHANG, Youqing XU

2021, 37(7): 1648-1651. DOI: 10.3969/j.issn.1001-5256.2021.07.033

Abstract(825)

HTML (740)

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Abstract:
Objective To investigate the value of contrast-enhanced endoscopic ultrasound (CE-EUS) versus contrast-enhanced computed tomography (CE-CT) in the diagnosis of pancreatic solid space-occupying lesions. Methods A total of 78 patients with pancreatic solid space-occupying lesions who attended Beijing ...

Effect of Braun anastomosis on delayed gastric emptying after pancreaticoduodenectomy

Sijie YANG, Hui ZHANG, Zhengfeng WANG, Zhilong SHI, Wence ZHOU

2021, 37(7): 1652-1656. DOI: 10.3969/j.issn.1001-5256.2021.07.034

Abstract(695)

HTML (533)

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Abstract:
Objective To investigate the effect of Braun anastomosis (BE) on delayed gastric emptying (DGE) after pancreaticoduodenectomy (PD). Methods A retrospective analysis was performed for the clinical data of 132 patients who underwent PD in The First Hospital of Lanzhou University from December 2016 to ...

Original articles_Splenic diseases

Change in follicular helper T cells in the peripheral blood and spleen of rats after Echinococcus multilocularis infection

Yaogang ZHANG, Jianhua LI, Jing HOU, Li SUN, Meiyuan TIAN, Yuan JIANG, Dengliang HUANG, Tao ZHANG, Yanyan MA, Haining FAN

2021, 37(7): 1657-1661. DOI: 10.3969/j.issn.1001-5256.2021.07.035

Abstract(1258)

HTML (194)

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Abstract:
Objective To investigate the level of follicular helper T (Tfh) cells in the peripheral blood and spleen of the host after Echinococcus multilocularis infection and its association with the progression of echinococcosis. Methods A total of 20 Sprague-Dawley rats were randomly divided into normal con...

Case reports

Jaundice and portal hypertension caused by hepatic epithelioid hemangioendothelioma: A case report

Ruihua ZHANG, Tingting QIN, Yueming SHAO, Yu ZHANG, Yang WANG, Xiaoyu WEN

2021, 37(7): 1662-1664. DOI: 10.3969/j.issn.1001-5256.2021.07.036

Abstract(750)

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Abstract:

Primary fibrosarcoma of the liver misdiagnosed as hepatic abscess: A case report

Liuyang ZHU, Jiancun HOU, Long YANG, Wen TONG, Yamin ZHANG

2021, 37(7): 1665-1667. DOI: 10.3969/j.issn.1001-5256.2021.07.037

Abstract(499)

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Abstract:

Primary splenic Kaposi sarcoma: A case report

Youchun LI, Guichao XU, Wenlei QI

2021, 37(7): 1668-1669. DOI: 10.3969/j.issn.1001-5256.2021.07.038

Abstract(564)

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Abstract:

HIV infection with acute liver failure as the main manifestation: A case report

Fang YUAN, Jun SHI, Hailin TANG, Yiqun ZHOU, Fang XUE

2021, 37(7): 1670-1672. DOI: 10.3969/j.issn.1001-5256.2021.07.039

Abstract(541)

HTML (247)

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Abstract:

Bronchobiliary fistula after microwave ablation of hepatic hydatid disease: A case report

Liuxin ZHOU, Ya GUO, Jiaqi YUAN, Li REN, Haijiu WANG, Haining FAN, Zhixin WANG

2021, 37(7): 1673-1675. DOI: 10.3969/j.issn.1001-5256.2021.07.040

Abstract(624)

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Abstract:

Intraductal papillary neoplasm of the bile duct with atrophy of the hepatic left lateral lobe: A case report

Jingzhong OUYANG, Ruili ZHU, Yanzhao ZHOU, Zhengzheng WANG, Xun CHEN, Jinxue ZHOU, Qingjun LI

2021, 37(7): 1676-1678. DOI: 10.3969/j.issn.1001-5256.2021.07.041

Abstract(577)

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Abstract:

Primary splenic lymphoma with jaundice and spontaneous splenic rupture: A case report

Qiuyan YAO, Zesheng WU, Rongjie SHI, Liwei YANG

2021, 37(7): 1679-1681. DOI: 10.3969/j.issn.1001-5256.2021.07.042

Abstract(708)

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Abstract:

Reviews

Influencing factors for serum HBsAg clearance in people with chronic hepatitis B virus infection and its clinical significance

Jinwei DUAN, Peng ZHANG, Jing ZHANG, Wanjia ZENG, Fengmin LU

2021, 37(7): 1682-1685. DOI: 10.3969/j.issn.1001-5256.2021.07.043

Abstract(1074)

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Abstract:
HBsAg clearance can significantly reduce the risk of end-stage liver disease and liver cancer in patients with chronic hepatitis B; however, HBsAg clearance rate is very low, either by spontaneous clearance or antiviral therapy. This article summarizes the influencing factors for spontaneous clearan...

Application of machine learning in hepatitis B virus-related liver diseases

Fajuan RUI, Qi XUE, Cuihong LIU, Zhaoyang GUO, Hongli YANG, Chuanli LIU, Yayun XU, Wanhua REN, Chengyong QIN, Jie LI

2021, 37(7): 1686-1689. DOI: 10.3969/j.issn.1001-5256.2021.07.044

Abstract(680)

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Abstract:
Machine learning has been more and more widely used in the medical field in recent years, and new advances have been made in the diagnosis and treatment of breast cancer, diabetic retinopathy, neuropsychiatric diseases, and atherosclerosis. Machine learning is showing great potential in the diagnosi...

Advances in the treatment of liver cirrhosis with portal vein thrombosis

Xiaoke LI, Xinle YANG, Tong WANG, Shuwen XUE, Xiaolin GUO, Huifan JI

2021, 37(7): 1690-1693. DOI: 10.3969/j.issn.1001-5256.2021.07.045

Abstract(1056)

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Abstract:
Portal vein thrombosis (PVT) is one of the most common complications of liver cirrhosis. Due to coagulation disorder and the risk of bleeding in liver cirrhosis, there are many controversies over the treatment of liver cirrhosis with PVT in clinical practice. Common therapies for PVT include anticoa...

Gut microbiota regulation and diet therapy for hepatic encephalopathy

Yingyu LE, Rongzhen ZHANG, Weisong XIAO, Xiaobin QIN, Shenglan ZENG, Dewen MAO

2021, 37(7): 1694-1698. DOI: 10.3969/j.issn.1001-5256.2021.07.046

Abstract(655)

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Abstract:
Hepatic encephalopathy (HE) greatly increases the economic burden of patients with liver disease and seriously affects their quality of life. HE has a complex pathological basis and various influencing factors, and its pathogenesis has not been fully clarified. There is still no specific effective t...

Advances in investigational new drugs for nonalcoholic fatty liver disease

Kun XU, Xu ZHANG, Ying LI, Zhenbin HU

2021, 37(7): 1699-1703. DOI: 10.3969/j.issn.1001-5256.2021.07.047

Abstract(654)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is closely associated with obesity, insulin resistance, and other metabolic diseases. There are currently no drugs approved for treatment, and routine lifestyle management can hardly have a positive impact on thi...

Regulatory role of long non-coding RNAs in the development and progression of nonalcoholic fatty liver disease

Zhihua ZUO, Chuyi ZENG, Yao JIANG, Hualin TAO, Yongcan GUO

2021, 37(7): 1704-1707. DOI: 10.3969/j.issn.1001-5256.2021.07.048

Abstract(792)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) is characterized by fatty degeneration, lipid metabolism disorders, and abnormal deposition in hepatocytes, and it has become the most prevalent liver disease in the world. The role of long non-coding RNAs (lncRNAs) in the development and progression of NAFLD...

Influence of estrogen deficiency on metabolic associated fatty liver disease in postmenopausal women

Chenlu ZHAO, Wenxia ZHAO

2021, 37(7): 1708-1712. DOI: 10.3969/j.issn.1001-5256.2021.07.049

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Abstract:
Epidemiological data have shown that postmenopausal women have a significantly higher incidence rate of metabolic associated fatty liver disease (MAFLD) than premenopausal women and men of the same age. Aiming at this phenomenon, this article summarizes the potential influence mechanism of estrogen ...

Research advances in related factors for autophagy in the regulation of nonalcoholic fatty liver disease

Jiahe ZHAO, Xinyu MA, Jingya XU, Tingting DUAN, Chunlei ZHANG, Baolong LI

2021, 37(7): 1713-1717. DOI: 10.3969/j.issn.1001-5256.2021.07.050

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a common disease characterized by the accumulation of lipid droplets (LDs) in hepatocytes. Clinical studies have shown that NAFLD not only has complex causes, but also can induce cardiovascular diseases and diabetes; however, there are still no effective t...

Research advances in the role of the glucocorticoid-induced tumor necrosis factor receptor-related protein and its ligand in liver diseases

Yu HE, Jidong JIA, Ping WANG

2021, 37(7): 1718-1723. DOI: 10.3969/j.issn.1001-5256.2021.07.051

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Abstract:
Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a member of the tumor necrosis factor receptor superfamily, and after it specifically binds to GITR ligand (GITRL), the downstream signals mediated by them can not only serve as a costimulatory molecule to promote the proliferation and ...

Role of microRNA-122 in the development, progression, and diagnosis of liver disease

Zeshan CHEN, Bin WEN, Peirong QIU, Hongni LAN, Baote HUANG, Xin DENG

2021, 37(7): 1724-1728. DOI: 10.3969/j.issn.1001-5256.2021.07.052

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MicroRNA is a type of small non-coding RNA that participates in multiple links such as cell proliferation and apoptosis by regulating gene expression after transcription. More and more studies have shown that microRNA-122 (miRNA-122) is involved in the development and progression of a variety of liv...

Research advances in non-surgical treatment of distal cholangiocarcinoma

Shanshan CHEN, Wei LI

2021, 37(7): 1729-1732. DOI: 10.3969/j.issn.1001-5256.2021.07.053

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Distal cholangiocarcinoma is a type of extrahepatic cholangiocarcinoma with high invasiveness and poor prognosis, and due to its low rate of early detection, most patients are in the advanced stage at the time of diagnosis. In recent years, with the continuous improvement of medical techniques such ...

Research advances in the methods for measuring spleen volume

Yonghai CHEN, Yunfu LYU, Jinfang ZHENG

2021, 37(7): 1733-1736. DOI: 10.3969/j.issn.1001-5256.2021.07.054

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Abstract:
Accurate measurement of spleen volume plays an important role in evaluating related diseases and prognosis. At present, there are various methods for measuring or estimating spleen volume. This article reviews the advances in several methods for measuring spleen volume, including the 5-rib unit esti...