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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 7
Jul.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(7): 1609-1613

The change in the prevalence of fatty liver disease and related influencing factors among Karamay residents in 2009-2016 and related influencing factors

DOI: 10.3969/j.issn.1001-5256.2021.07.026
  • 1a.

    Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China

  • 1b.

    Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China

  • 2a.

    Medical Examination Center, Karamay Central Hospital, Karamay, Xinjiang 834099, China

  • 2b.

    Department of Gastroenterology, Karamay Central Hospital, Karamay, Xinjiang 834099, China

  • 3.

    Department of Gastroenterology, Pudong Hospital Affiliated to Fudan University, Shanghai 201399, China

Research funding:

Wang Baoen Liver Fibrosis Research Foundation of Chinese Foundation for Hepatitis Prevention and Control (WBE20181025);

Talents Training Program of Pudong Hospital affiliated to Fudan University (YJRCJJ201801);

Shannxi Province General Projects-Social Development (2020SF-297);

National Key Research and Development Program of China during the 13th Five-Year Plan Period (2018YFC1311504)

  • Received Date: 2020-12-07
  • Accepted Date: 2021-01-26
  • Published Date: 2021-07-20
    Abstract
  •   Objective  To investigate the change in the prevalence rate of fatty liver disease (FLD) and related influencing factors among individuals undergoing physical examination in Karamay Central Hospital from 2009 to 2016, and to provide a reference for the prevention and treatment of FLD.  Methods  Abdominal ultrasound (230 330 cases) was performed in Karamay Central Hospital from January 2009 to December 2016, and related data were used to analyze the change in the prevalence rate of FLD and compare the difference between male and female individuals. A total of 33 195 individuals who underwent physical examination in 2016 and had complete data of age, body mass index (BMI), fasting blood glucose, and triglyceride were selected to analyze the prevalence rate of FLD among the individuals with different ages, BMIs, and sexes. A multivariate logistic regression analysis was used to investigate independent influencing factors for the development of FLD. The chi-square test was used for comparison of categorical data between groups; the t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups.  Results  From 2009 to 2016, the prevalence rate of FLD increased from 19.4% to 31.9% among the individuals who underwent physical examination in Karamay Central Hospital (P < 0.001); the prevalence rate increased from 22.8% to 39.5% among male individuals (P < 0.001), and the prevalence rate increased from 11.8% to 21.6% among female individuals (P < 0.001), suggesting that male individuals had a significantly higher prevalence rate than female individuals in each year (P < 0.001). Among the individuals who underwent physical examination in 2016, the prevalence rate of FLD was 26.1% in 17 848 young individuals, 37.3% in 10 017 middle-aged individuals, and 41.7% in 5330 elderly individuals (P < 0.001); the young and middle-aged male individuals had a significantly higher risk of FLD than the female individuals in the same age group (both P < 0.001), and the elderly male individuals had a significantly lower risk of FLD than the female individuals in the same age group (P=0.022). There were 865 individuals with emaciation, 13 510 with normal body weight, 12 755 with overweight, and 6065 with obesity, with a prevalence rate of FLD of 0.8%, 9.5%, 39.6%, and 70.6%, respectively (P < 0.001), and the stratified analysis based on BMI showed that male individuals had a significantly higher prevalence rate of FLD than females individuals (P < 0.05). The multivariate logistic regression analysis showed that age, sex, BMI, systolic pressure, diastolic pressure, alanine aminotransferase, total bilirubin, fasting blood glucose, triglyceride, total cholesterol, and serum uric acid were independent influencing factors for FLD (all P < 0.05).  Conclusion  There is a rapid increase in the prevalence rate of FLD among the residents of Karamay, and there are various risk factors. It is recommended to strengthen policy intervention, provide public education, screen out the high-risk population, and implement preventive and treatment measures as early as possible, so as to reduce related medical burden.

     

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    • References(21)
  • [1]
    YOUNOSSI ZM, KOENIG AB, ABDELATIF D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes[J]. Hepatology, 2016, 64(1): 73-84. DOI: 10.1002/hep.28431.
    [2]
    WANG XJ, MALHI H. Nonalcoholic fatty liver disease[J]. Ann Intern Med, 2018, 169(9): ITC65-ITC80. DOI: 10.7326/AITC201811060.
    [3]
    TOMIC D, KEMP WW, ROBERTS SK. Nonalcoholic fatty liver disease: Current concepts, epidemiology and management strategies[J]. Eur J Gastroenterol Hepatol, 2018, 30(10): 1103-1115. DOI: 10.1097/MEG.0000000000001235.
    [4]
    LI XY, YUAN PG. Non-alcoholic fatty liver disease is ominous disease with slow progress[J]. Mod Med Heal, 2017, 33(5): 647-650. DOI: 10.3969/j.issn.1009-5519.2017.05.003.

    李秀英, 袁平戈. 非酒精性脂肪性肝病是进展缓慢的非良性疾病[J]. 现代医药卫生, 2017, 33(5): 647-650. DOI: 10.3969/j.issn.1009-5519.2017.05.003.
    [5]
    MENG YL, ZHANG HY, SONG BG, et al. An investigation of the prevalence rate of fatty liver disease among people undergoing physical examination in Tangshan, China[J]. J Clin Hepatol, 2017, 33(12): 2376-2380. DOI: 10.3969/j.issn.1001-5256.2017.12.024.

    孟昱林, 张海艳, 宋宝国, 等. 唐山市体检人群脂肪肝患病率调查分析[J]. 临床肝胆病杂志, 2017, 33(12): 2376-2380. DOI: 10.3969/j.issn.1001-5256.2017.12.024.
    [6]
    ZHOU F, ZHOU J, WANG W, et al. Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: A systematic review and Meta-analysis[J]. Hepatology, 2019, 70(4): 1119-1133. DOI: 10.1002/hep.30702.
    [7]
    ZHU JZ, ZHOU QY, WANG YM, et al. Prevalence of fatty liver disease and the economy in China: A systematic review[J]. World J Gastroenterol, 2015, 21(18): 5695-5706. DOI: 10.3748/wjg.v21.i18.5695.
    [8]
    LIN S, XIAN Y, LIU Y, et al. Risk factors and community intervention for nonalcoholic fatty liver disease in community residents of Urumqi, China[J]. Medicine (Baltimore), 2018, 97(9): e0021. DOI: 10.1097/MD.0000000000010021.
    [9]
    WANG L, WU GL, GE L. Investigation of fatty liver in health examination of residents in Kuytun area[J]. Bull Dis Control Prev (CHINA), 2018, 33(2): 54-55, 58. DOI: 10.13215/j.cnki.jbyfkztb.1712001.

    王琳, 吴桂玲, 葛亮. 奎屯地区居民健康体检脂肪肝的调查[J]. 疾病预防控制通报, 2018, 33(2): 54-55, 58. DOI: 10.13215/j.cnki.jbyfkztb.1712001.
    [10]
    HUA HQ, WANG DM, NUERJIANG SMY, et al. A study on the main health problems and their influencing factors of residents in Kezhou, Xinjiang based on big data of physical examination[J]. J Nanjing Med Univ(Natural Sci), 2019, 39(7): 1016-1020. DOI: 10.7655/NYDXBNS20190715.

    华海庆, 王冬梅, 努尔江·司马义, 等. 基于健康体检大数据的新疆克州地区居民最主要健康问题及其影响因素研究[J]. 南京医科大学学报(自然科学版), 2019, 39(7): 1016-1020. DOI: 10.7655/NYDXBNS20190715.
    [11]
    LU Y, LI HJ. Analysis of health examination results of employees in an oil field from 2009 to 2011[J]. Xinjiang Med J, 2012, 42(2): 119-121. DOI: 10.3969/j.issn.1001-5183.2012.02.051.

    卢琰, 李厚隽. 某油田单位职工2009年-2011年健康体检结果分析[J]. 新疆医学, 2012, 42(2): 119-121. DOI: 10.3969/j.issn.1001-5183.2012.02.051.
    [12]
    Fatty Liver Expert Committee, Chinese Medical Doctor Association, ational Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease: A 2018 update[J]. J Clin Hepatol, 2018, 34(5): 947-957. DOI: 10.3969/j.issn.1001-5256.2018.05.007.

    中国医师协会脂肪性肝病专家委员会, 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病防治指南(2018年更新版)[J]. 临床肝胆病杂志, 2018, 34(5): 947-957. DOI: 10.3969/j.issn.1001-5256.2018.05.007.
    [13]
    YAN H, LU XL, GAO YQ, et al. Epidemiological investigation of fatty liver disease in Northwest China[J]. Chin J Hepatol, 23(8): 622-627. DOI: 10.3760/cma.j.issn.1007-3418.2015.08.013.

    延华, 鲁晓岚, 高艳琼, 等. 西北地区脂肪性肝病的流行病学调查研究[J]. 中华肝脏病杂志, 2015, 23(8): 622-627. DOI: 10.3760/cma.j.issn.1007-3418.2015.08.013.
    [14]
    ARNER P, BERNARD S, APPELSVED L, et al. Adipose lipid turnover and long-term changes in body weight[J]. Nat Med, 2019, 25(9): 1385-1389. DOI: 10.1038/s41591-019-0565-5.
    [15]
    KO SH, KIM HS. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women[J]. Nutrients, 2020, 12(1): 202. DOI: 10.3390/nu12010202.
    [16]
    GUO JX, GUO LJ. Study on the detection rate and related factors of fatty liver in physical examination population[J]. Chin Med J Metall Indus, 2020, 37(3): 25225-25224. DOI: 10.13586/j.cnki.yjyx1984.2020.03.004.

    郭建霞, 郭来敬. 体检人群的脂肪肝检出率及相关因素研究[J]. 中国冶金工业医学杂志, 2020, 37(3): 25225-25224. DOI: 10.13586/j.cnki.yjyx1984.2020.03.004.
    [17]
    ZHNAG YN, LIU YT. Prevalence of nonalcoholic fatty liver disease and related influencing factors in health examination population in Shenyang[J]. J Pub Health and Prev Med, 2019, 30(3): 67-70. DOI: 10.3969/j.issn.1006-2483.2019.03.015.

    章雅南, 刘奕婷. 沈阳市健康体检人群非酒精性脂肪肝患病情况及影响因素[J]. 公共卫生与预防医学, 2019, 30(3): 67-70. DOI: 10.3969/j.issn.1006-2483.2019.03.015.
    [18]
    HUANG XY. An analysis of the prevalence and epidemiological characteristics of fatty liver disease among the physical examination population in Meizhou from 2015 to 2016[J]. Chin Prev Med, 2018, 19(5): 395-397. DOI: 10.16506/j.1009-6639.2018.05.017.

    黄向阳. 2015-2016年梅州市体检人群脂肪肝患病率及流行病学特点分析[J]. 中国预防医学杂志, 2018, 19(5): 395-397. DOI: 10.16506/j.1009-6639.2018.05.017.
    [19]
    YOUNOSSI Z, ANSTEE QM, MARIETTI M, et al. Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention[J]. Nat Rev Gastroenterol Hepatol, 2018, 15(1): 11-20. DOI: 10.1038/nrgastro.2017.109.
    [20]
    WU TF, LIAO XH, ZHONG BH. Epidemiology of nonalcoholic fatty liver disease in some regions of China[J]. J Clin Hepatol, 2020, 36(6): 1370-1373. DOI: 10.3969/j.issn.1001-5256.2020.06.039.

    吴挺丰, 廖献花, 钟碧慧. 中国部分地区非酒精性脂肪肝病的流行情况[J]. 临床肝胆病杂志, 2020, 36(6): 1370-1373. DOI: 10.3969/j.issn.1001-5256.2020.06.039.
    [21]
    HUANG Y, HUANG ZG. Analysis on epidemiological characteristics of circulatory disease mortality, Karamay city, 2018[J]. Prev Med Trib, 2020, 26(4): 290-292. DOI: 10.16406/j.pmt.issn.1672-9153.2020.04.015.

    黄芸, 黄志光. 2018年克拉玛依市循环系统疾病死亡流行特征分析[J]. 预防医学论坛, 2020, 26(4): 290-292. DOI: 10.16406/j.pmt.issn.1672-9153.2020.04.015.
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