Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

Yanyan CHEN; Yanmei LAN; Minggang WANG; Dewen. MAO

doi:10.3969/j.issn.1001-5256.2021.02.049

Volume 37 Issue 2

Mar. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(2): 480-484

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Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

DOI: 10.3969/j.issn.1001-5256.2021.02.049

1.
Department of Basic Medicine, Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China
2a.
Department of Scientific Research, Nanning 530023, China
2b.
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Received Date: 2020-07-16
Accepted Date: 2020-08-17
Published Date: 2021-02-20

Abstract

Abstract

Liver failure is a common critical medical disease, and extensive liver cell necrosis within a short period of time exceeds the regeneration capacity of liver cells and thus results in an extremely high fatality rate. Promotion of effective liver regeneration is the key to antagonizing liver failure. Recent studies have shown that bile acid, farnesoid X receptor (FXR), and intestinal microecology play an important role in liver failure and liver regeneration. This article reviews the association between bile acid, FXR, and intestinal microecology and their role in liver failure and liver regeneration, so as to provide new ideas for the treatment of liver failure in clinical practice.
- Liver Failure,
- Liver Regeneration,
- Bile Acid,
- Farnesol Receptor R,
- Gastrointestinal Microbiome

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References(59)

References

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Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

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Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

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