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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 3
Mar.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(3): 708-713

Association between cholesterol and liver regeneration and its significance and potential value in clinical treatment of liver failure

DOI: 10.3969/j.issn.1001-5256.2022.03.044
  • 1.

    Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China

  • 2.

    Second Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

  • 3.

    Guangxi University of Chinese Medicine, Nanning 530000, China

Research funding:

National Natural Science Foundation of China (81704021);

National Natural Science Foundation of China (81760844);

National Natural Science Foundation of China (8170150729);

National Major Science Technology Project (2018ZX10725505-001-011);

Guangxi Science and Technology Plan Project (2020GXNSFAA297098);

Postgraduate Innovation Project of Guangxi University of Chinese Medicine (YCXJ2021034)

More Information
  • Corresponding author: YAO Chun, 1197840425@qq.com(ORCID: 0000-0002-6612-874X)
  • Received Date: 2021-07-13
  • Accepted Date: 2021-08-13
  • Published Date: 2022-03-20
    Abstract
  • Liver failure is a common severe liver disease syndrome in clinical practice and is one of the critical medical conditions in internal medicine. Massive hepatocyte death is the main pathological feature of liver failure, and its core mechanisms include endotoxin, immune response, and inflammatory cascade reaction. Effective regeneration of hepatocytes to compensate liver function is the physiological basis for promoting the good prognosis of liver failure, which directly affects the prognosis and quality of life of patients with liver failure. It has been found in clinical practice that liver failure patients with a low serum level of cholesterol tend to have an extremely high mortality rate, but as an index of hepatocyte anabolism, the association between cholesterol and hepatocyte regeneration has not been taken seriously. Based on the association between cholesterol and liver regeneration, this article reviews its significance and potential value in the clinical treatment of liver failure, in order to understand the pathogenesis of liver failure from another perspective and provide new ideas for the diagnosis and treatment of liver failure and the development of drugs.

     

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