中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2015
Turn off MathJax
Article Contents

Prevention and treatment of liver fibrosis by regulating liver regeneration

DOI: 10.3969/j.issn.1001-5256.2015.06.041
Research funding:

 

  • Received Date: 2014-11-06
  • Published Date: 2015-06-20
  • Liver fibrosis is regarded as a form or status of liver regeneration disorder. Therefore,from a new perspective of regulating liver regeneration,we put forward a new strategy for the prevention and treatment of liver fibrosis. This strategy not only focuses on confrontational reverse regulation,but also emphasizes positive induction. Moreover,this strategy applies an integrated method of promotion and inhibition,which improves liver injury and regeneration and corrects the abnormal liver regeneration and the normal liver regeneration disorder. Furthermore,this strategy also advocates the combination of prevention and treatment,which prevents the occurrence of liver fibrosis or a disorder of liver regeneration and treats the rapid progression of liver fibrosis. The imbalance between epithelial- mesenchymal transition( EMT) and mesenchymal- epithelial transition( MET) is involved in the CCl4- induced liver fibrosis in rats. Diwu Yanggan capsules can delay the progression of liver fibrosis and attenuate the degree of fibrosis,which is associated with the regulation of liver regeneration by modulating the imbalance between EMT and MET( inhibiting EMT and / or promoting MET).

     

  • loading
  • [1]SHI WQ.The idea about the both importance in anti-virus treatment and anti-liver fibrosis treatment[J].Chin J Integr Tradit West Med Liver Dis,2013,23(5):257-258.(in Chinese)施维群.关于抗病毒与抗肝纤维化治疗并重的理念[J].中西医结合肝病杂志,2013,23(5):257-258.
    [2]LI HM.The comprehensive,systematic and in-depth study on Traditional Chinese Medicine for regulating liver regeneration[J].Chin J Integr Tradit West Med Liver Dis,2007,17(3):129-132.(in Chinese)李瀚旻.全面系统深入地研究中医药调控肝再生[J].中西医结合肝病杂志,2007,17(3):129-132.
    [3]LI HM.Introducation of regenerative Traditional Chinese Medicine[J].Chin Arch Tradit Chin Med,2008,26(11):2309-2312.(in Chinese)李瀚旻.中医再生医学概论[J].中华中医药学刊,2008,26(11):2309-2312.
    [4]LI HM,GAO X,YAN XS.The influence of Zuogui Wan extract on bone marrow stem cell transforming liver cell[J].J Clin Hepatol,2012,28(3):192-195.(in Chinese)李瀚旻,高翔,晏雪生.左归丸粗提取物对骨髓干细胞转化肝细胞的影响[J].临床肝胆病杂志,2012,28(3):192-195.
    [5]LI HM.Therapy rule of“nourishing kidney to produce marrow and form liver”[J].Chin Arch Tradit Chin Med,2012,30(5):937-940.(in Chinese)李瀚旻.论“补肾生髓成肝”治疗法则[J].中华中医药学刊,2012,30(5):937-940.
    [6]HIGGINS G,ANDERSON R.Experimental pathology of the liver.I.Restoration of the liver of the white rat following partial surgical removal[J].Arch Pathol,1931,12:186-202.
    [7]LDDE T,KUBICKA S,PLMPE J,et al.Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy[J].Oncogene,2001,20(38):5264-5278.
    [8]LI HM.The regulatory network of nerve-endocrine-immune-liver regeneration[J].Chin J Integr Tradit West Med Liver Dis,2014,24(4):193-196.(in Chinese)李瀚旻.神经-内分泌-免疫-肝再生调控网络[J].中西医结合肝病杂志,2014,24(4):193-196.
    [9]VAN WAES L,LIEBER CS.Early perivenular sclerosis in alcoholic fatty liver:an index of progressive liver injury[J].Gastroenterology,1977,73(4 Pt 1):646-650.
    [10]FRIEDMAN SL.Hepatic fibrosis-overview[J].Toxicology,2008,254(3):120-129.
    [11]KORDES C,SAWITZA I,MLLER-MARBACH A,et al.CD133+hepatic stellate cells are progenitor cells[J].Biochem Biophys Res Commun,2007,353(2):410-417.
    [12]CHOI SS,OMENETTI A,WITEK RP,et al.Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis[J].Am J Physiol Gastrointest Liver Physiol,2009,297(6):g1093-g1106.
    [13]SICKLICK JK,CHOI SS,BUSTAMANTE M,et al.Evidence for epithelial-mesenchymal transitions in adult liver cells[J].Am J Physiol Gastrointest Liver Physiol,2006,291(4):g575-g583.
    [14]YANG L,JUNG Y,OMENETTI A,et al.Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers[J].Stem Cells,2008,26(8):2104-2113.
    [15]SWIDERSKA-SYN M,SYN WK,XIE G,et al.Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy[J].Gut,2014,63(8):1333-1344.
    [16]YUE HY,YIN C,HOU JL,et al.Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats[J].Gut,2010,59(2):236-246.
    [17]LI HM.“Marrow stem cells fail to transform into liver cells”and the imbalance epithelial-mesenchymal transition and mesenchymal-epithelial transition[J].Chin J Integr Tradit West Med Liver Dis,2012,22(1):1-4.(in Chinese)李瀚旻.上皮-间质转型/间质-上皮转型失衡与髓失生肝[J].中西医结合肝病杂志,2012,22(1):1-4.
    [18]LI HM.Fundamental and clinical application for liver disease treatment with therapeutic principle of"tonifying the kidney to promote liver regeneration and repair"[J].World Sci Technol/Mod Tradit Chin Med Mater Med,2013,15(6):1425-1428.(in Chinese)李瀚旻.“补肾生髓成肝”治疗肝脏病的基础及临床应用[J].世界科学技术—中医药现代化,2013,15(6):1425-1428.
    [19]XIE G,DIEHL AM.Evidence for and against epithelial-to-mesenchymal transition in the live[J].Am J Physiol Gastrointest Liver Physiol,2013,305(12):g881-g890.
    [20]FU LZ,ZHENG T,ZHANG YS.Advances in understanding the role of TGF-β/Smad signolling pathwocys in the pathogenesis of liver fibrosis[J].Chin J Clin Pharmacol Ther,2014,19(10):1189-1195.(in Chinese)付玲珠,郑婷,张永生.TGF-β/Smad信号转导通路与肝纤维化研究进展[J].中国临床药理学与治疗学,2014,19(10):1189-1195.
    [21]BI WR,JIN CX,XU GT,et al.Bone morphogenetic protein-7 regulates Snail signaling in carbon tetrachloride-induced fibrosis in the rat liver[J].Exp Ther Med,2012,4(6):1022-1026.
    [22]YANG G,ZHU Z,WANG Y,et al.Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats[J].Toxicol Lett,2013,220(2):103-108.
    [23]SHEN X,CHENG SS,PENG Y,et al.Attenuation of early liver fibrosis by herbal compound“Diwu Yanggan”through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition[J].BMC Complement Altern Med,2014,14:418.
    [24]OMENETTI A,CHOI S,MICHELOTTI G,et al.Hedgehog signaling in the liver[J].J Hepatol,2011,54(2):366-373.
    [25]OMENETTI A,YANG L,LI YX,et al.Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation[J].Lab Invest,2007,87(5):499-514.
    [26]CHENG F,LI Y,FENG L,et al.Hepatic stellate cell activation and hepatic fibrosis induced by ischemia/reperfusion injury[J].Transplant Proc,2008,40(7):2167-2170.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2866) PDF downloads(495) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return