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转化生长因子β在胰腺癌发生发展中的作用

张浩 刘林勋 赵占学 潘洪帅 侯晓凡 霍峥

引用本文:
Citation:

转化生长因子β在胰腺癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2022.12.041
基金项目: 

青海省卫健委指导项目 2020-wjzdx-28

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:张浩负责课题设计,资料分析,撰写论文;侯晓凡、霍峥负责查阅文献;刘林勋、赵占学、潘洪帅负责校正,修改论文,最后定稿。
详细信息
    通信作者:

    刘林勋, 147599835@qq.com

Role of transforming growth factor-β in the development and progression of pancreatic cancer

Research funding: 

Qinghai Provincial Health Commission Guidance Project 2020-wjzdx-28

More Information
    Corresponding author: LIU Linxun, 147599835@qq.com (ORCID: 0000-0003-1998-5746)
  • 摘要: 胰腺导管腺癌恶性程度高,起病隐匿,病情进展快,在早期无明显的腹部表现及体征。多数患者就诊时已发展为中晚期,并常伴远处脏器转移,因此手术治疗、放化疗及药物靶向治疗效果通常不佳。近年来研究表明,转化生长因子β(TGFβ)与肿瘤的发生、发展密不可分,在肿瘤细胞的增殖、侵袭、迁移和血管的生成等进程中发挥关键性的调节作用。尽管TGFβ信号能够利用SMAD介导的细胞周期阻滞起到强大的肿瘤抑制作用,但是TGFβ信号也可以通过增强上皮-间质转化、纤维化和免疫逃逸来加速胰腺癌的发生。本文所述胰腺癌均特指为胰腺导管腺癌,旨在对TGFβ在其信号传导中的作用及其相关因子和免疫反应等方面关系的研究予以综述,为今后胰腺癌的靶向治疗提供理论依据。

     

  • 图  1  胰腺癌微环境中TGFβ信号通路

    Figure  1.  TGFβ signaling pathway in the pancreatic tumor microenvironment

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  • 收稿日期:  2022-07-15
  • 录用日期:  2022-09-13
  • 出版日期:  2022-12-20
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