中文English
ISSN 1001-5256
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肝硬化营养支持的研究进展

何玉梅 伍丽萍 王治铭 郝梦昊 胡玲 李佳珍 孙晓滨

引用本文:
Citation:

肝硬化营养支持的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.12.031
基金项目: 

国家自然科学基金青年科学基金项目 81700467;

成都市第五批技术创新研发项目 2021-YF05-00585-SN;

四川省重点研发项目 2022YFS0340;

成都市卫健委项目 202103031154

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:何玉梅、王治铭、郝梦昊负责查阅文献和撰写论文;胡玲、李佳珍、孙晓滨负责修改论文;伍丽萍拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    伍丽萍,wuliping1985116@163.com

Research progress in nutritional support for liver cirrhosis patients

Research funding: 

National Natural Science Foundation of China 81700467;

The Fifth Batch of Technological Innovation R & D Project of Chengdu 2021-YF05-00585-SN;

Sichuan Provincial Key R & D Project 2022YFS0340;

Chengdu Health Commission Research Project 202103031154

More Information
  • 摘要: 肝硬化营养不良与腹水、肝性脑病、感染等并发症及病死率有关,但目前肝硬化患者营养不良的危害与疾病负担被严重低估。本文将结合国内外最新研究,对肝硬化营养支持进行深入探讨,以期探索有效筛查、评估、干预途径,进一步指导临床实践。

     

  • [1] JAVAID N, KHAN Z, ALI MA, et al. Evaluating the impact of early nutritional assessment and intervention in hospitalized liver cirrhosis patients[J]. Arq Gastroenterol, 2022, 59(1): 22-28. DOI: 10.1590/S0004-2803.202200001-05.
    [2] KOULENTAKI M, DRYGIANNAKIS I, MANTAKA A, et al. Nutritional assessment of greek liver cirrhosis patients: mini nutritional assessment predicts mortality[J]. Healthcare (Basel), 2022, 10(5): 859. DOI: 10.3390/healthcare10050859.
    [3] BELLANTI F, LO BUGLIO A, QUIETE S, et al. Comparison of three nutritional screening tools with the new glim criteria for malnutrition and association with sarcopenia in hospitalized older patients[J]. J Clin Med, 2020, 9(6): 1898. DOI: 10.3390/jcm9061898.
    [4] MAHARSHI S, SHARMA BC, SRIVASTAVA S. Malnutrition in cirrhosis increases morbidity and mortality[J]. J Gastroenterol Hepatol, 2015, 30(10): 1507-1513. DOI: 10.1111/jgh.12999.
    [5] Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Gastroenterology, Chinese Medical Association. Clinical guidelines on nutrition in end-stage liver disease[J]. J Clin Hepatol, 2019, 35(6): 1222-1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010.

    中华医学会肝病学分会, 中华医学会消化病学分会. 终末期肝病临床营养指南[J]. 临床肝胆病杂志, 2019, 35(6): 1222-1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010.
    [6] PALMER LB, KUFTINEC G, PEARLMAN M, et al. Nutrition in cirrhosis[J]. Curr Gastroenterol Rep, 2019, 21(8): 38. DOI: 10.1007/s11894-019-0706-5.
    [7] KONDRUP J. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials[J]. Clin Nutr, 2003, 22(3): 321-336. DOI: 10.1016/s0261-5614(02)00214-5.
    [8] MCFARLANE M, HAMMOND C, ROPER T, et al. Comparing assessment tools for detecting undernutrition in patients with liver cirrhosis[J]. Clin Nutr ESPEN, 2018, 23: 156-161. DOI: 10.1016/j.clnesp.2017.10.009.
    [9] DHALIWAL A, TOWEY J, LORD JM, et al. Nutrition in liver cirrhosis: a case-based overview[J]. Frontline Gastroenterol, 2020, 11(2): 155-161. DOI: 10.1136/flgastro-2018-101121.
    [10] BORHOFEN SM, GERNER C, LEHMANN J, et al. The royal free hospital-nutritional prioritizing tool is an independent predictor of deterioration of liver function and survival in cirrhosis[J]. Dig Dis Sci, 2016, 61(6): 1735-1743. DOI: 10.1007/s10620-015-4015-z.
    [11] AMODIO P, BEMEUR C, BUTTERWORTH R, et al. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus[J]. Hepatology, 2013, 58(1): 325-336. DOI: 10.1002/hep.26370.
    [12] WU Y, ZHU Y, FENG Y, et al. Royal Free Hospital-Nutritional Prioritizing Tool improves the prediction of malnutrition risk outcomes in liver cirrhosis patients compared with Nutritional Risk Screening 2002[J]. Br J Nutr, 2020, 124(12): 1293-1302. DOI: 10.1017/S0007114520002366.
    [13] European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease[J]. J Hepatol, 2019, 70(1): 172-193. DOI: 10.1016/j.jhep.2018.06.024.
    [14] DAǦ Z, KÖSEOǦLU H, KEKILLI M. The use of prealbumin as a predictor of malnutrition in cirrhotic patients and the effect of nutritional support in patients with low prealbumin levels[J]. Turk J Med Sci, 2020, 50(2): 398-404. DOI: 10.3906/sag-1910-27.
    [15] BAKSHI N, SINGH K. Nutrition assessment in patients undergoing liver transplant[J]. Indian J Crit Care Med, 2014, 18(10): 672-681. DOI: 10.4103/0972-5229.142177.
    [16] CICHOŻ-LACH H, MICHALAK A. A Comprehensive review of bioelectrical impedance analysis and other methods in the assessment of nutritional status in patients with liver cirrhosis[J]. Gastroenterol Res Pract, 2017, 2017: 6765856. DOI: 10.1155/2017/6765856.
    [17] BELARMINO G, GONZALEZ MC, TORRINHAS RS, et al. Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis[J]. World J Hepatol, 2017, 9(7): 401-408. DOI: 10.4254/wjh.v9.i7.401.
    [18] HOPKINSON J. Psychosocial support in cancer cachexia syndrome: the evidence for supported self-management of eating problems during radiotherapy or chemotherapy treatment[J]. Asia Pac J Oncol Nurs, 2018, 5(4): 358-368. DOI: 10.4103/apjon.apjon_12_18.
    [19] LAI JC, TANDON P, BERNAL W, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases[J]. Hepatology, 2021, 74(3): 1611-1644. DOI: 10.1002/hep.32049.
    [20] PLAUTH M, BERNAL W, DASARATHY S, et al. ESPEN guideline on clinical nutrition in liver disease[J]. Clin Nutr, 2019, 38(2): 485-521. DOI: 10.1016/j.clnu.2018.12.022.
    [21] WANG R, ZHANG YG, LI QQ, et al. Evaluation value of area index of the third lumbar psoas major muscle in nutritional status and prognosis of patients with cirrhosis[J]. Clin J Med Offic, 2022, 50(7): 729-732. DOI: 10.16680/j.1671-3826.2022.07.18.

    王然, 张永国, 李谦谦, 等. 第三腰椎腰大肌面积指数对肝硬化患者营养状态及预后评估价值[J]. 临床军医杂志, 2022, 50(7): 729-732. DOI: 10.16680/j.1671-3826.2022.07.18.
    [22] EBADI M, TANDON P, MOCTEZUMA-VELAZQUEZ C, et al. Low subcutaneous adiposity associates with higher mortality in female patients with cirrhosis[J]. J Hepatol, 2018, 69(3): 608-616. DOI: 10.1016/j.jhep.2018.04.015.
    [23] GEORGIOU A, PAPATHEODORIDIS GV, ALEXOPOULOU A, et al. Evaluation of the effectiveness of eight screening tools in detecting risk of malnutrition in cirrhotic patients: the KIRRHOS study[J]. Br J Nutr, 2019, 122(12): 1368-1376. DOI: 10.1017/S0007114519002277.
    [24] FIGUEIREDO FA, PEREZ RM, FREITAS MM, et al. Comparison of three methods of nutritional assessment in liver cirrhosis: subjective global assessment, traditional nutritional parameters, and body composition analysis[J]. J Gastroenterol, 2006, 41(5): 476-482. DOI: 10.1007/s00535-006-1794-1.
    [25] MORGAN MY, MADDEN AM, SOULSBY CT, et al. Derivation and validation of a new global method for assessing nutritional status in patients with cirrhosis[J]. Hepatology, 2006, 44(4): 823-835. DOI: 10.1002/hep.21358.
    [26] PERUMPAIL BJ, LI AA, CHOLANKERIL G, et al. Optimizing the nutritional support of adult patients in the setting of cirrhosis[J]. Nutrients, 2017, 9(10): 1114. DOI: 10.3390/nu9101114.
    [27] BISCHOFF SC, BERNAL W, DASARATHY S, et al. ESPEN practical guideline: Clinical nutrition in liver disease[J]. Clin Nutr, 2020, 39(12): 3533-3562. DOI: 10.1016/j.clnu.2020.09.001.
    [28] FIALLA AD, ISRAELSEN M, HAMBERG O, et al. Nutritional therapy in cirrhosis or alcoholic hepatitis: a systematic review and meta-analysis[J]. Liver Int, 2015, 35(9): 2072-2078. DOI: 10.1111/liv.12798.
    [29] HOU W, WANG ZY, DONG JL, et al. Application of enteral nutrition and late evening snacks in patients with liver cirrhosis[J]. Clin Med J, 2019, 17 (4): 33-37. DOI: 10.3969/j.issn.1672-3384.2019.04.008.

    侯维, 王忠英, 董金玲, 等. 肠内营养及睡前加餐在肝硬化患者中的应用效果评价[J]. 临床药物治疗杂志, 2019, 17(4): 33-37. DOI: 10.3969/j.issn.1672-3384.2019.04.008.
    [30] SHERGILL R, SYED W, RIZVI SA, et al. Nutritional support in chronic liver disease and cirrhotics[J]. World J Hepatol, 2018, 10(10): 685-694. DOI: 10.4254/wjh.v10.i10.685.
    [31] SINGER P, BLASER AR, BERGER MM, et al. ESPEN guideline on clinical nutrition in the intensive care unit[J]. Clin Nutr, 2019, 38(1): 48-79. DOI: 10.1016/j.clnu.2018.08.037.
    [32] BAGER P, OLESEN L, BALTZER RL, et al. Equal efficacy of gastric and jejunal tube feeding in liver cirrhosis and/or alcoholic hepatitis: a randomised controlled study[J]. Br J Nurs, 2020, 29(20): 1148-1154. DOI: 10.12968/bjon.2020.29.20.1148.
    [33] PLAUTH M, CABRÉ E, RIGGIO O, et al. ESPEN guidelines on enteral nutrition: liver disease[J]. Clin Nutr, 2006, 25(2): 285-294. DOI: 10.1016/j.clnu.2006.01.018.
    [34] PLAUTH M, CABRÉ E, CAMPILLO B, et al. ESPEN guidelines on parenteral nutrition: hepatology[J]. Clin Nutr, 2009, 28(4): 436-444. DOI: 10.1016/j.clnu.2009.04.019.
    [35] REINTAM BLASER A, STARKOPF J, ALHAZZANI W, et al. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines[J]. Intensive Care Med, 2017, 43(3): 380-398. DOI: 10.1007/s00134-016-4665-0.
    [36] ASLAM M, FAROOQ S, RIZWAN B, et al. Assessment of nutritional status of the cirrhotic patients on enteral and parenteral feeding[J]. Nutr Health, 2022, 28(1): 69-76. DOI: 10.1177/02601060211020968.
    [37] TAJIRI K, SHIMIZU Y. Branched-chain amino acids in liver diseases[J]. World J Gastroenterol, 2013, 19(43): 7620-7629. DOI: 10.3748/wjg.v19.i43.7620.
    [38] SAKAI Y, IWATA Y, ENOMOTO H, et al. Two randomized controlled studies comparing the nutritional benefits of branched-chain amino acid (BCAA) granules and a BCAA-enriched nutrient mixture for patients with esophageal varices after endoscopic treatment[J]. J Gastroenterol, 2015, 50(1): 109-118. DOI: 10.1007/s00535-014-0950-2.
    [39] PARK JG, TAK WY, PARK SY, et al. Effects of Branched-Chain Amino Acid (BCAA) supplementation on the progression of advanced liver disease: A Korean Nationwide, Multicenter, Prospective, Observational, Cohort Study[J]. Nutrients, 2020, 12(5): 1429. DOI: 10.3390/nu12051429.
    [40] LES I, DOVAL E, GARCÍA-MARTÍNEZ R, et al. Effects of branched-chain amino acids supplementation in patients with cirrhosis and a previous episode of hepatic encephalopathy: a randomized study[J]. Am J Gastroenterol, 2011, 106(6): 1081-1088. DOI: 10.1038/ajg.2011.9.
  • 加载中
计量
  • 文章访问数:  1118
  • HTML全文浏览量:  867
  • PDF下载量:  87
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-04-22
  • 录用日期:  2022-08-02
  • 出版日期:  2022-12-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回