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沉默调节蛋白1在酒精性肝病中的作用机制及相关药物研究进展

刘甜恬 刘江凯 李素领 刘靓 张雅儒 张建文 李冰倩

引用本文:
Citation:

沉默调节蛋白1在酒精性肝病中的作用机制及相关药物研究进展

DOI: 10.3969/j.issn.1001-5256.2022.12.030
基金项目: 

国家自然科学基金(联合基金) U1504825;

河南省高等学校重点科研项目 20A360014;

河南省中医药拔尖人才培养项目资助 Yuwei Traditional Chinese Medicine 2021 No.15

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:刘甜恬负责课题设计,资料分析,撰写论文;李素领负责修改论文;刘靓、张雅儒、张建文、李冰倩参与收集及分析文献资料;刘江凯负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    刘江凯,xmlc001@126.com

Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies

Research funding: 

National Natural Science Foundation of China (Joint Fund) U1504825;

Key Scientific Research Projects of Colleges and Universities in Henan Province 20A360014;

Henan Provincial Top talents training Program of Traditional Chinese Medicine Yuwei Traditional Chinese Medicine 2021 No.15

More Information
    Corresponding author: LIU Jiangkai, xmlc001@126.com (ORCID: 0000-0002-1529-5089)
  • 摘要: 酒精性肝病(ALD)是全球慢性肝病的主要病种之一,我国ALD发病率正逐年上升且呈年轻化发展态势。沉默调节蛋白1(SIRT1)是一种烟酰胺腺嘌呤二核苷酸依赖性的脱乙酰化酶,在细胞代谢、氧化应激、炎症反应等方面作用显著,有望成为ALD治疗新靶点。本文总结了SIRT1在ALD中的作用机制及相关药物研究,以期为进一步研究ALD发病机制及其潜在治疗靶标提供参考和策略。

     

  • 图  1  SIRT1调节ALD的机制

    Figure  1.  Mechanism of SIRT1 regulating ALD

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  • 收稿日期:  2022-05-07
  • 录用日期:  2022-06-17
  • 出版日期:  2022-12-20
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