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线粒体障碍在非酒精性脂肪性肝炎中的作用机制

蔡恬莹 黄美州 陈浩 钱保林 付文广

蔡恬莹,黄美州,陈浩,等. 线粒体障碍在非酒精性脂肪性肝炎中的作用机制[J]. 临床肝胆病杂志, 2021, 37(8): 1953-1956. DOI: 10.3969/j.issn.1001-5256.2021.08.045
引用本文: 蔡恬莹,黄美州,陈浩,等. 线粒体障碍在非酒精性脂肪性肝炎中的作用机制[J]. 临床肝胆病杂志, 2021, 37(8): 1953-1956. DOI: 10.3969/j.issn.1001-5256.2021.08.045
CAI TY, HUANG MZ, CHEN H, et al. Mechanism of action of mitochondrial disorders in nonalcoholic steatohepatitis[J]. J Clin Hepatol, 2021, 37(8): 1953-1956. DOI: 10.3969/j.issn.1001-5256.2021.08.045
Citation: CAI TY, HUANG MZ, CHEN H, et al. Mechanism of action of mitochondrial disorders in nonalcoholic steatohepatitis[J]. J Clin Hepatol, 2021, 37(8): 1953-1956. DOI: 10.3969/j.issn.1001-5256.2021.08.045

线粒体障碍在非酒精性脂肪性肝炎中的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.08.045
基金项目: 

四川省科技项目基金 2017SZYZF0015

详细信息
    通讯作者:

    付文广,fuwg@swmu.edu.cn

  • 中图分类号: R575.5

Mechanism of action of mitochondrial disorders in nonalcoholic steatohepatitis

Funds: 

Foundation of Science and Technology Projects of Sichuan Province 2017SZYZF0015

  • 摘要: 非酒精性脂肪性肝炎(NASH)是一种以肝脂肪变性、肝细胞炎症和肝纤维化为主要特征的常见慢性肝病。研究表明,线粒体内脂质代谢异常和活性氧生成、线粒体呼吸链受损、线粒体破裂以及线粒体自噬异常等线粒体障碍在NASH的发生、发展及转归过程中发挥重要作用。以NASH中肝脂肪代谢异常、肝炎发生和肝纤维化为主要线索,总结线粒体结构破坏、功能障碍以及线粒体自噬受损在NASH中的作用机制,以寻找相应靶点指导对NASH的治疗。

     

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  • 收稿日期:  2021-01-15
  • 修回日期:  2021-02-23
  • 刊出日期:  2021-08-16
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