铁死亡的发生机制及在肝脏疾病中的作用

张飞宇; 阿迪拉·亚克普; 赵金明; 高沿航

doi:10.3969/j.issn.1001-5256.2021.06.049

铁死亡的发生机制及在肝脏疾病中的作用

DOI: 10.3969/j.issn.1001-5256.2021.06.049

吉林大学第一医院肝病科，长春 130021

基金项目:

国家自然科学基金 (81972265);

国家重点研发计划“精准医学研究”专项 (2017YFC0908103);

“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项 (2017ZX10202202);

“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项 (2018ZX10302206);

吉林省自然科学基金 (20200201324JC)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张飞宇负责选题，收集分析资料，撰写文章；阿迪拉·亚克普、赵金明参与选题，收集资料；高沿航教授拟定写作思路，指导撰写文章，提供修改意见并最终定稿。

详细信息

作者简介:
张飞宇(1995—)，男，主要从事肝胆胰腺疾病研究

通信作者:
高沿航，yanhang@mail.jlu.edu.cn

中图分类号: R575
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- 文章访问数: 1100
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- 被引次数: 0
出版历程
- 收稿日期: 2020-11-30
- 录用日期: 2020-12-29
- 出版日期: 2021-06-20

Mechanism of ferroptosis and its role in liver diseases

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China

摘要

摘要: 铁死亡是新近发现的一种铁依赖性、脂质过氧化物集聚导致的调节性细胞死亡，其形态学特征为线粒体体积缩小、膜密度增加和线粒体减少或消失。发生机制主要与铁代谢紊乱、氨基酸抗氧化系统失衡、脂质过氧化物集聚有关。研究显示，铁死亡在不同的肝脏疾病背景下扮演不同角色，铁死亡的发生可参与多种肝脏炎症疾病进展，也可抑制肝纤维化形成、肝癌发生及索拉非尼耐药。总结了铁死亡发生机制及其在肝脏疾病中的作用和进展，旨在为肝脏疾病的进一步研究与治疗提供参考。
- 肝疾病 /
- 铁死亡 /
- 细胞死亡 /
- 铁代谢
Abstract: Ferroptosis is a newly discovered regulatory cell death induced by the accumulation of iron-dependent lipid peroxides, with the morphological manifestations of decreased mitochondrial volume, increased mitochondrial membrane density, and reduction or disappearance of mitochondria. The mechanism of ferroptosis is mainly associated with disturbance of iron metabolism, imbalance of amino acid antioxidant system, and accumulation of lipid peroxides. Studies have shown that ferroptosis plays different roles in different liver diseases, and ferroptosis can participate in the progression of various liver inflammatory diseases and inhibit the formation of liver fibrosis, the development of hepatocellular carcinoma, and sorafenib resistance. This article summarizes the advances in the mechanism of ferroptosis and its role in liver diseases, so as to provide a reference for further research and treatment of liver diseases.
- Liver Diseases /
- Ferroptosis /
- Cell Death /
- Iron Metabolism

HTML全文

图 1 4种细胞死亡方式机制图

注：a, 肝细胞的外源性凋亡机制; b, 坏死性凋亡机制; c, 焦亡机制; d, 自噬机制。

下载: 全尺寸图片幻灯片

图 2 铁死亡发生机制图

下载: 全尺寸图片幻灯片

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