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不同亚型Numb蛋白对肝纤维化相关信号通路的影响

许燕楠 刘平 慕永平

许燕楠, 刘平, 慕永平. 不同亚型Numb蛋白对肝纤维化相关信号通路的影响[J]. 临床肝胆病杂志, 2021, 37(1): 169-172. DOI: 10.3969/j.issn.1001-5256.2021.01.036
引用本文: 许燕楠, 刘平, 慕永平. 不同亚型Numb蛋白对肝纤维化相关信号通路的影响[J]. 临床肝胆病杂志, 2021, 37(1): 169-172. DOI: 10.3969/j.issn.1001-5256.2021.01.036
XU YN, LIU P, MU YP. Effects of different subtypes of Numb protein subtypes on liver fibrosis-related signaling pathways [J]. J Clin Hepatol, 2021, 37(1): 169-172. DOI: 10.3969/j.issn.1001-5256.2021.01.036
Citation: XU YN, LIU P, MU YP. Effects of different subtypes of Numb protein subtypes on liver fibrosis-related signaling pathways [J]. J Clin Hepatol, 2021, 37(1): 169-172. DOI: 10.3969/j.issn.1001-5256.2021.01.036

不同亚型Numb蛋白对肝纤维化相关信号通路的影响

DOI: 10.3969/j.issn.1001-5256.2021.01.036
基金项目: 

国家自然科学基金面上项目 81573948

国家自然科学基金面上项目 81874390

详细信息
    作者简介:

    许燕楠(1995—),女,主要从事肝硬化的基础和临床研究

    通讯作者:

    慕永平,ypmu8888@126.com

  • 作者贡献说明:许燕楠负责收集查阅文献并撰写论文;刘平负责修改论文;慕永平负责指导撰写文章并最后定稿。
  • 中图分类号: R575.2

Effects of different subtypes of Numb protein subtypes on liver fibrosis-related signaling pathways

  • 摘要: 肝纤维化是各种慢性肝病发展为肝硬化的必经之路,是一个可逆的病理状态。但如何阻抑或逆转肝纤维化的发生与发展,仍是临床需要解决的重要科学问题。Numb,一个重要的细胞命运决定子,已被发现与多种疾病的发生密切相关。在肝纤维化环境中,由于Numb基因的选择性剪切作用,翻译出不同亚型的Numb蛋白,其对不同信号通路的活化以及肝干细胞的分化具有不同的调节作用。目前关于Numb蛋白不同亚型在肝纤维化中的作用报道较少。综述了不同亚型Numb蛋白对Notch、Hedgehog、P53信号通路以及对肝干细胞的调控作用,阐释其在肝纤维化治疗中的潜在应用前景。
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  • 收稿日期:  2020-07-28
  • 修回日期:  2020-08-28
  • 刊出日期:  2021-01-18
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