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肝硬化的定义、病因及流行病学

单姗 赵连晖 马红 欧晓娟 尤红 贾继东

单姗, 赵连晖, 马红, 等. 肝硬化的定义、病因及流行病学[J]. 临床肝胆病杂志, 2021, 37(1): 14-16. DOI: 10.3969/j.issn.1001-5256.2021.01.003
引用本文: 单姗, 赵连晖, 马红, 等. 肝硬化的定义、病因及流行病学[J]. 临床肝胆病杂志, 2021, 37(1): 14-16. DOI: 10.3969/j.issn.1001-5256.2021.01.003
SHAN S, ZHAO LH, MA H, et al. Definition,etiolo-gy,and epidemiology of liver cirrhosis[J]. J Clin Hepatol, 2021, 37(1): 14-16. DOI: 10.3969/j.issn.1001-5256.2021.01.003
Citation: SHAN S, ZHAO LH, MA H, et al. Definition,etiolo-gy,and epidemiology of liver cirrhosis[J]. J Clin Hepatol, 2021, 37(1): 14-16. DOI: 10.3969/j.issn.1001-5256.2021.01.003

肝硬化的定义、病因及流行病学

DOI: 10.3969/j.issn.1001-5256.2021.01.003
基金项目: 

国家科技重大专项课题 2018ZX09201016

北京市科学技术委员会医药协同科技创新研究专项 Z191100007619037

详细信息
    作者简介:

    单姗(1981—),女,主治医师,主要从事慢性乙型肝炎的真实世界研究

    通讯作者:

    贾继东,jia_jd@ccmu.edu.cn

  • 作者贡献声明:单姗负责撰写论文;赵连晖负责文献筛选和整理数据;马红、欧晓娟、尤红负责修改论文;贾继东负责拟定写作思路,指导撰写文章并最后定稿。
  • 中图分类号: R575.2

Definition, etiology, and epidemiology of liver cirrhosis

  • 摘要: 肝硬化是全球肝脏相关死亡的主要原因,最常见的原因是慢性乙型和丙型肝炎、酒精性肝病、非酒精性脂肪性肝病。近年研究显示,世界范围内,肝硬化死亡人数增加,但年龄标准化死亡率降低;失代偿期肝硬化的年龄标准化患病率显著增加。我国肝硬化患病人数、患病率、死亡人数和死亡率均有所增加,但是年龄标准化的患病率和死亡率均有所降低;主要病因仍为慢性乙型肝炎,但酒精性及非酒精性脂肪性肝病所致肝硬化比例也逐渐增加。
  • 表  1  肝硬化的病因

    分类 具体病因
    感染性 慢性病毒性肝炎(HBV、HCV)、寄生虫病(血吸虫病)等
    化学损伤性 酒精性、药物性、毒物性肝病等
    自身免疫性 自身免疫性肝炎、原发性胆汁性胆管炎、原发性硬化性胆管炎等
    胆汁淤积性 先天性胆道闭锁,Allagile综合征,进行性家族性肝内胆汁淤积等
    代谢性及遗传性 非酒精性脂肪性肝病、Wilson病、遗传性血色病、α1-抗胰蛋白酶缺乏症、糖原累积病、希川缺乏病等多种遗传代谢性肝病
    血管性 肝外门静脉阻塞、肝窦阻塞综合征、Budd-Chiari综合征、右心血液回流障碍(右心衰竭、心肌病、缩窄性心包炎等)及遗传性出血性毛细血管扩张症等
    下载: 导出CSV
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  • 收稿日期:  2020-11-20
  • 修回日期:  2020-11-20
  • 刊出日期:  2021-01-18
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