HBV相关肝细胞癌的发生机制

颜永聪; 温凯; 毛凯; 肖治宇; 王捷

doi:10.3969/j.issn.1001-5256.2020.10.002

HBV相关肝细胞癌的发生机制

DOI: 10.3969/j.issn.1001-5256.2020.10.002

中山大学孙逸仙纪念医院肝胆外科

基金项目:

国家自然科学基金资助项目(81572407,81672405,81602112)；

详细信息

中图分类号: R735.7;R512.62
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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-14
- 出版日期: 2020-10-20

Pathogenesis of hepatitis B virus-related hepatocellular carcinoma

Department of Hepatobiliary Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University

Research funding:

摘要

摘要: 肝细胞癌是最常见的致死性肿瘤之一。慢性HBV感染是肝细胞癌的主要危险因素。介绍了HBV相关肝细胞癌的具体机制,包括HBV X蛋白、免疫失衡以及病毒DNA整合入宿主基因组,并重点阐述HBV X蛋白在肝细胞癌中的病理作用及其相关机制。HBV X蛋白通过促进肿瘤细胞增殖、侵袭转移,影响血管形成,促进细胞凋亡和导致代谢重组而发挥其致癌作用。深化对HBV X蛋白生物学功能、免疫失衡以及病毒DNA整合的相关研究将有助于阐明肝癌的发生机制,促进HBV相关肝癌新型治疗靶标的开发。
- 癌,肝细胞 /
- 乙型肝炎病毒 /
- 致癌作用
Abstract: Hepatocellular carcinoma( HCC) is one of the major malignant tumors that lead to death,and chronic hepatitis B virus( HBV)infection is an important risk factor for HCC. This article introduces the detailed mechanisms of HBV-related HCC,including HBV X protein,immune imbalance,and integration of HBV DNA into the host genome,with a focus on the pathological role and related mechanisms of HBV X protein in HCC. HBV X protein enhances carcinogenesis by promoting tumor cell proliferation,invasion,and metastasis,affecting angiogenesis,promoting cell apoptosis,and interfering with cell metabolism. In-depth studies on the biological functions of HBV X protein,immune imbalance,and HBV DNA integration will help to clarify the pathogenesis of liver cancer and promote the development of novel therapeutic targets for HBV-related HCC.
- carcinoma,hepatocellular /
- hepatitis B virus /
- carcinogenesis

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参考文献(75)

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