线粒体与肝细胞损伤的关系

魏海梁; 司明明; 郭辉; 李京涛; 李倩; 闫曙光; 鞠迪

doi:10.3969/j.issn.1001-5256.2020.03.048

线粒体与肝细胞损伤的关系

DOI: 10.3969/j.issn.1001-5256.2020.03.048

1. 陕西中医药大学附属医院普外一科
2. 陕西中医药大学附属医院肝病科
3. 陕西中医药大学基础医学院

基金项目:

国家自然科学基金项目(81603612,81904192)；陕西省科技厅课题(2012SF2-11,2014K11-02-04-06,2016SF-234)；陕西省中医药管理局课题(15-JC009)；陕西中医药大学学科创新团队建设项目(2019-YL05)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-11-29
- 出版日期: 2020-03-20

Association between mitochondria and hepatocellular injury

First Department of General Surgery,The Affiliated Hospital of Shaanxi University of Chinese Medicine

Research funding:

摘要

摘要: 在肝脏组织中,线粒体不但为肝细胞的物质代谢提供了能量,同时还广泛参与了肝细胞损伤甚至凋亡的过程,在与肝细胞损伤、凋亡密切相关的肝炎、肝纤维化、肝癌癌前病变及肝癌的病理过程中也发挥了重要的作用。从线粒体膜通透性的改变在肝细胞损伤中的重要作用、ATP合成障碍及消耗加速肝细胞损伤以及肝细胞线粒体Ca2+稳态异常与肝细胞损伤关系等方面阐述了线粒体与肝细胞损伤之间的关系,以期以线粒体为靶点,为防治肝细胞损伤引起的慢性肝脏疾病提供理论依据。
- 线粒体,肝 /
- 肝疾病 /
- 肝细胞损伤
Abstract: The mitochondria in liver tissue not only provides energy for substance metabolism in hepatocytes,but also participates in hepatocellular injury and even apoptosis. It also plays an important role in several pathological processes closely associated with hepatocellular injury and apoptosis,such as hepatitis,hepatic fibrosis,precancerous lesion,and liver cancer. This article elaborates on the association between mitochondria and hepatocellular injury from the following aspects: the important role of the change in mitochondrial membrane permeability in hepatocellular injury,hepatocellular injury accelerated by ATP synthesis disorder and consumption,and the association of abnormal Ca2+ homeostasis in hepatocellular mitochondria with hepatocellular injury,in order to provide a theoretical basis for mitochondria-targeted prevention and treatment of chronic liver diseases due to hepatocellular injury.
- mitochondria,liver /
- liver diseases /
- hepatocyte injury

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参考文献(30)

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