大学教师胆结石患病现状及危险因素的多中心研究

张弛; 胡舒铃; 孙鹏; 白烨; 王宇彤; 张本; 谷冬晴; 王新

doi:10.3969/j.issn.1001-5256.2020.03.031

大学教师胆结石患病现状及危险因素的多中心研究

DOI: 10.3969/j.issn.1001-5256.2020.03.031

1. 天津医科大学肿瘤医院预防科国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室天津市恶性肿瘤临床医学研究中心
2. 陆军军医大学第一附属医院流行病学中心
3. 哈尔滨医科大学第二附属医院普外科
4. 国家癌症中心中国医学科学院肿瘤医院结直肠外科
5. 重庆医科大学公共卫生学院流行病与卫生统计科

基金项目:

国家自然科学基金项目(81673255,81874283,81903393,81903398)；国家“千人计划”青年项目；陆军军医大学临床医学科研人才培养计划(2018XLC1004);陆军军医大学拔尖人才培养计划基金(SWH2018BJKJ-12);陆军军医大学第一附属医院重大领域技术创新计划(SWH2016ZDCX1012)；重庆市自然科学基金面上项目(cstc2019jcyj-msxm X0466)；

详细信息

中图分类号: R575.62
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出版历程
- 收稿日期: 2019-09-12
- 出版日期: 2020-03-20

Prevalence of gallstones among university teachers and related risk factors: A multicenter study

National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin Clinical Research Center for Cancer,Department of Prevention,Tianjin Medical University Cancer Institute and Hospital

Research funding:

摘要

摘要: 目的研究天津市大学教师胆结石的患病率及其危险因素。方法收集2015年在天津医科大学肿瘤医院健康体检中心参加体检的五所高校教师的体检数据,采用腹部超声对胆结石进行诊断。计数资料组间比较采用χ~2检验。采用单因素及多因素logistic回归法分析不同大学胆结石患病的独立危险因素,并采用Meta分析的方法对不同大学教师患病率及危险因素进行合并。结果共纳入大学教师8006人,其中440人被诊断为胆结石,合并后胆结石患病率为5. 5%。Meta分析结果显示,高血压[比值比(OR)=1. 67,95%可信区间(95%CI):1. 32～2. 12,P <0. 001]、脂肪肝(OR=1. 39,95%CI:1. 12～1. 72,P <0. 001)、肾结石(OR=1. 90,95%CI:1. 15～3. 14,P=0. 01)、较高水平的己糖激酶(OR=1. 42,95%CI:1. 03～1. 94,P=0. 03)、较高水平的ALT(OR=1. 32,95%CI:1. 01～1. 73,P=0. 04)和高球蛋白水平(OR=1. 74,95%CI:1. 08～2. 79,P=0. ...
- 胆结石 /
- 危险因素 /
- 高校教师 /
- 多中心研究(主题)
Abstract: Objective To investigate the prevalence rate of gallstones among university teachers in Tianjin,China,and related risk factors.Methods Physical examination data were collected from the teachers from five universities who participated in physical examination in Physical Examination Center,Tianjin Medical University Cancer Institute and Hospital,in 2015,and abdominal ultrasound was used for the diagnosis of gallstones. The chi-square test was used for comparison of categorical data between groups. Univariate and multivariate logistic regression analyses were used to identify the risk factors for gallstones in the teachers from different universities,and a meta-analysis was used for the pooled analysis of prevalence rate and risk factors. Results A total of 8006 university teachers were enrolled,among whom 440 were diagnosed with gallstones,and the pooled prevalence rate of gallstones was 5. 5%. The meta-analysis showed that hypertension( odds ratio[OR]= 1. 67,95% confidence interval [CI]: 1. 32-2. 12,P <0. 001),fatty liver( OR =1. 39,95% CI: 1. 12-1. 72,P < 0. 001),kidney stones( OR = 1. 90,95% CI: 1. 15-3. 14,P = 0. 01),and high levels of hexokinase( OR = 1. 42,95% CI: 1. 03-1. 94,P = 0. 03),alanine aminotransferase( OR = 1. 32,95% CI: 1. 01-1. 73,P = 0. 04),and globulin( OR = 1. 74,95% CI: 1. 08-2. 79,P = 0. 02) were risk factors for gallstones. Conclusion There is a relatively low prevalence rate of gallstones among university teachers in Tianjin,and hypertension,fatty liver,kidney stones,and high levels of hexokinase,alanine aminotransferase,and globulin may be the risk factors for gallstones.
- cholelithiasis /
- risk factors /
- college teachers /
- multicenter studies as topic

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